Internal Medicine

Mitochondrial dysfunction is an early and pivotal event in acute pancreatitis. Could mitochondria represent an attractive target for therapeutic intervention and how might mitochondria-directed strategies work?

The dose-dependent cardiotoxicities of anthracyclines require careful cardiovascular monitoring. Discover how the latest diagnostic advances in imaging modalities, biomarkers, and genetic screening are refining patient care.

This international consensus statement integrates epidemiological, mechanistic, and interventional research findings, emphasizing the clinical relevance of maintaining adequate vitamin D status across a range of systems.

Sleep and diet are both recognized as global health concerns. Explore how the combined impact of sleep deprivation and ultra-processed food intake may exert convergent or additive effects on testosterone regulation.

A treat-to-target approach may be better than symptom-driven care for improving long-term gout control without increasing the risk for adverse events.

US guidelines have been published for the diagnosis and treatment of the three most common breast infections.

Semaglutide use in a man with type 2 diabetes and spinal and bulbar muscular atrophy treated with leuprorelin. Over 2 years glycemic parameters improved and fat mass reduced, with only a minor annual decrease in muscle mass.

The immediate postpartum period is a uniquely vulnerable time for women with alcohol-associated cirrhosis. In this case, postpartum esophageal variceal bleeding after cesarean section precipitated acute-on-chronic liver failure.

Radiofrequency ablation does not improve overall survival for patients with locally advanced pancreatic cancer who are undergoing chemotherapy and is associated with poorer quality of life.

ST-elevation myocardial infarction and non-ST-elevation myocardial infarction show distinct risk profiles in type 1 diabetes, highlighting the need for early, comprehensive cardiovascular prevention.


Thoracic aortic surgery in patients who refuse blood transfusion poses unique challenges. In this case, a bloodless surgical strategy using the frozen elephant trunk technique was successful in treating acute type A aortic dissection.

Autoimmune-related dry eye disease is often refractory to conventional first-line treatments, with anti-inflammatory and immunomodulatory therapies instead crucial for long-term control. This stepwise approach provides insights from real-world cases.

This case highlights the importance of heightened clinical suspicion, early identification, and treatment of macrophage activation syndrome in individuals with VEXAS syndrome.

This rare case of autochthonous neurocysticercosis in rural Germany underscores the need to consider NCC in patients with new‑onset generalized seizures and compatible neuroimaging findings, even in non‑endemic settings.

Serial measures of Epstein-Barr virus antibody titers may differentiate multiple sclerosis from other inflammatory autoimmune diseases of the central nervous system.

Early recognition and aggressive immunosuppression are essential to preventing irreversible neurological damage in Neuro‑Behçet syndrome. Explore the emerging diagnostic techniques and evolving long‑term treatment strategies improving patient outcomes.

Left atrial appendage closure fails to match medical therapy for preventing stroke and major events in high-risk atrial fibrillation, the CLOSURE-AF trial shows.

Adding evolocumab to background statin therapy substantially reduces the risk for a major adverse cardiovascular event in high-risk patients with diabetes who do not have significant atherosclerosis.

Is HRT appropriate after risk-reducing surgery in BRCA mutation carriers with a history of triple-negative breast cancer? What do current international guidelines, evidence, and expert recommendations suggest?

IBS can significantly impact older adults, but what do we know about the effect of age-related changes on the diagnosis and treatment of IBS in older adults compared with their younger counterparts?