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Internal Medicine

Case Studies

Primary CSF-lymphatic fistula can cause SIH

Open Access Spinal Space-Occupying Lesion Case Study

Spinal CSF leak from a dural tear or CSF-venous fistula are known causes of spontaneous intracranial hypotension, but this is the first case caused by a primary CSF-lymphatic fistula unrelated to vascular malformation.

Intravitreal injection of anti-VEGF resulting in heart failure

Open Access Heart Failure Case Study

An unusual case of heart failure caused by ten years of anti-vascular endothelial growth factor treatment for polypoidal choroidal vasculopathy. The HF resolved after cessation of anti-VEGF injections. 

Arginine vasopressin deficiency after COVID-19 vaccination

Open Access Arginine Vasopressin Deficiency Case Study

A case of AVP-D presumed to be triggered by vaccination against SARS-CoV-2. Persistent pituitary stalk enlargement and positive anti-rabphilin-3A antibodies helped diagnosis and avoided the need for pituitary biopsy.

Swyer–James–MacLeod syndrome mimicking pulmonary embolism

Open Access Respiratory Medicine Case Study

SJMS is a rare lung condition characterized by lung hyperlucency and reduction in the pulmonary vasculature. This case in an adult patient was initially misdiagnosed as a pulmonary embolism.

MI masking as wrist pain in a young man

Open Access Myocardial Infarction Case Study

A 41-year-old man presented with severe hand and wrist pain in both hands, and mild epigastric pain. An ECG showed anterior STEMI with an ejection fraction of 35–40%. Angiography showed severe left anterior descending artery and first obtuse marginal artery stenosis.

Migraine or temporal artery aneurysm?

Open Access Aneurysm Case Study

An extensive history of treatment-resistant migraine was eventually found to be a superficial aneurysm after the patient developed a painless lump in the left temporal region.

Fiberglass-associated constrictive pericarditis

Open Access Interstitial Lung Diseases Case Study

The first reported case of constrictive pericarditis in a patient with fiberglass lung disease. Careful review of exposure history and histopathological examinations are the key to diagnosis.

Accidental use of dulaglutide into the third trimester

Open Access Type 2 Diabetes Case Study

The GLP-1 receptor agonist dulaglutide was unintentionally used by a woman with type 2 diabetes until the third trimester of an unplanned and unrecognized pregnancy, but what was the outcome?

Vitamin D-dependent rickets complicated with RSV infection

Rickets Case Study

Vitamin D-dependent rickets type 1 A causes failure to thrive, hypotonia, and increased fracture risk, and may complicate the clinical course of lower respiratory tract infections. How would you address the therapeutic challenges in this toddler?

An unusual course of diabetes

Diabetes Case Study

A woman with a history of neonatal hyperglycemia and a relatively uneventful childhood without treatment, experienced significant hyperglycemia and retinopathy in adulthood, but what was the cause of her diabetes?

An unusual case of Sheehan syndrome

Open Access Sheehan Syndrome Case Study

Sheehan syndrome is usually characterized by anterior pituitary hypofunction, but in this case rapid-onset panhypopituitarism and arginine vasopressin deficiency developed after postpartum hemorrhage.

Brain on FIRES

Explore diagnosis and treatment of a 13-year-old previously healthy boy with febrile infection-related epilepsy syndrome associated with COVID-19 infection.

Dislodged PICC tip causing acute respiratory failure

Open Access Pleural Effusion Case Study

Complications from peripheral IV central catheters can be difficult to identify quickly in pediatric patients. Point-of-care ultrasound showed a massive pleural effusion in this infant.

A cardiac cause for peristent headache in a young man

A 20-year-old man presented with persistent slow-onset frontal headaches that worsened through the day. A diffuse pulmonary arteriovenous malformation was discovered, despite no family history of hereditary hemorrhagic telangiectasia.

Thyroid tuberculosis mimicking multinodular goiter

Open Access Tuberculosis Case Study

A woman presented with anterior neck swelling of 6 years’ duration that had recently increased in size. The absence of other significant clinical and laboratory findings delayed the diagnosis of thyroid tuberculosis.

A rare complication of COVID-19

Open Access COVID-19 Case Study

Recurrent spontaneous pneumothorax due to lung cystic lesions in a man recovering from COVID-19. Clinicians should consider CT scans 2 to 3 weeks after symptom onset to detect lesions and anticipate the complication.

Myasthenia gravis mimicking acute lacunar stroke

Open Access Myasthenia Gravis Case Study

Diagnosing myasthenic crisis with atypical presentation is very challenging, especially in elderly patients who can present with isolated dysarthria, suggesting lacunar stroke.

Necrotizing myopathy in a woman with type 1 diabetes

Open Access Diabetes-associated Diseases Case Study

Identifying the cause of muscle necrosis can be a diagnostic challenge, as shown by this case of diabetic myonecrosis complicated by pyomyositis and abscess caused by Escherichia coli.

An unusual cause of pleural effusion

Open Access Pleural Effusion Case Study

Only the third reported case of dirofilariasis – a mosquito-transmitted infection – manifesting in the pleural cavity. The patient was treated successfully with doxycycline and albendazole.

Ulcerative colitis in a transgender woman

Open Access Ulcerative Colitis Case Study

A transgender woman with a sigmoid neovagina developed bloody diarrhea and neovaginal bleeding 10 years after sex reassignment surgery, highlighting the need for long-term vigilance.