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Current Nutrition Reports

Intermittent Fasting in Cancer: a Role in Survivorship?

  • 31-05-2022
  • Cancer (RA Murphy, Section Editor)
Published in:
Authors
Eleah Stringer
Julian J. Lum
Nicol Macpherson
Published in
Current Nutrition Reports | Issue 3/2022

Abstract

Purpose of Review

To discuss the historical development of intermittent fasting, its potential underlying mechanisms, and the state of clinical trials, and to reflect on considerations for practice and future recommendations.

Recent Findings

Preclinical studies consistently show the robust disease-modifying efficacy of intermittent fasting in various metabolic diseases which may hold implications for cancer prevention and survivorship. Twenty-one clinical trials have or are being conducted on fasting in cancer, utilizing various fasting regimens across different tumor types as a stand-alone intervention or in adjunct to anticancer treatment, with heterogenous outcome variables.

Summary

Though there are no known, reproducible diets, to cure or prevent cancer recurrence, preliminary research on the underlying mechanisms, tolerance, and safety of intermittent fasting in cancer warrants further investigation. The inherent flexibility of intermittent fasting to accommodate all types of diets is of necessity in oncology.
Title
Intermittent Fasting in Cancer: a Role in Survivorship?
Authors
Eleah Stringer
Julian J. Lum
Nicol Macpherson
Publication date
31-05-2022
Publisher
Springer US
Published in
Current Nutrition Reports / Issue 3/2022
Electronic ISSN: 2161-3311
DOI
https://doi.org/10.1007/s13668-022-00425-0
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Colon cancer illustration/© (M) KATERYNA KON / SCIENCE PHOTO LIBRARY / Getty Images, Human brain illustration/© (M) CHRISTOPH BURGSTEDT / SCIENCE PHOTO LIBRARY / Getty Images