Skip to main content
Key Specialties
Anesthesiology Cardiology Dermatology Diabetology Endocrinology Gastroenterology General Medicine Geriatrics Hematology Infectious Diseases Internal Medicine Nephrology Neurology Obstetrics and Gynecology Oncology Ophthalmology Pediatrics Psychiatry Radiology Respiratory Medicine Rheumatology Surgery Urology
Congress Coverage
ASH 2024 Annual Meeting 2024 ESMO Congress 2024 ERS Congress 2024 EASD Congress 2024 ESC Congress 2024 EAN Congress 2024 ASCO Annual Meeting 2024 ACC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on adolescent vaping

LIVE: Wednesday 29th January, 18:00-19:30 CET

Growing numbers of young people are using e-cigarettes, despite warnings of respiratory effects and addiction. How can doctors tackle the epidemic, and what health effects should you prepare to manage in your clinics?
ADVANCED SEARCH
Log in
Top
International Ophthalmology
Published in:

09-07-2022 | Intense Pulsed Light | Original Paper

Posterior segment spectral domain oct in the differential diagnosis of bilateral temporal optic neuropathy and its correlation with visual acuity

Authors: Tom Buelens, Jean-François Fils, François Willermain

Published in: International Ophthalmology | Issue 12/2022

Login to get access

Abstract

Purpose

To identify the underlying etiologies and to evaluate the differential diagnostic value of posterior segment spectral domain OCT measurements and their correlation with best-corrected visual acuity (BCVA) in a group of patients with OCT documented bilateral optic neuropathy limited to the temporal quadrants.

Methods

Retrospective study.

Results

We included 61 patients: 35 presented with presumed “classic” acquired mitochondrial optic neuropathy (MON) (18 nutritional, 11 toxic, 6 mixed toxic-nutritional) and 2 with suspected hereditary MON. Nine patients were identified as ‘MON mimickers’ (especially multiple sclerosis), and 4 were found to have a mixed mechanism, while 11 remained undiagnosed. Across all etiologies, the strongest positive relationship between BCVA and tested OCT parameters was with macular GCL (ganglion cell layer) and GCIPL (combined ganglion cell and inner plexiform layer) volumes rather than peripapillary retinal nerve fiber layer (RNFL) thicknesses (all statistically significant). There was an inverse relationship between BCVA and inner nuclear layer (INL) volumes, with significant differences for BCVA and all tested OCT parameters between eyes with and without INL microcystoid lesions. OCT (absolute values and intereye differences) was not helpful in distinguishing between presumed acquired mitochondrial disease and patients with multiple sclerosis without optic neuritis. However, significantly greater intereye differences in global RNFL and inner plexiform layer and GCIPL volumes were found in patients with a previous history of unilateral optic neuritis.

Conclusions

The strongest positive relationship with BCVA was found for macular GCL and GCIPL volumes. OCT could not differentiate between acquired mitochondrial disease and multiple sclerosis without optic neuritis.
Appendix
Available only for authorised users
Literature
1.
Wang MY, Sadun AA (2013) Drug-related mitochondrial optic neuropathies. J Neuroophthalmol 33:172–178PubMedCrossRef
2.
Pilz YL, Bass SJ, Sherman J (2017) A review of mitochondrial optic neuropathies: from inherited to acquired forms. J Optom 10(4):205–214PubMedCrossRef
3.
Petzold A, Balcer LJ, Calabresi PA et al (2017) Retinal layer segmentation in multiple sclerosis: a systematic review and meta-analysis. Lancet Neurol 16:797–812PubMedCrossRef
4.
Oertel FC, Zimmermann HG, Brandt AU, Paul F (2019) Novel uses of retinal imaging with optical coherence tomography in multiple sclerosis. Expert Rev Neurother 19:31–43PubMedCrossRef
5.
Davion JB, Lopes R, Drumez É et al (2020) Asymptomatic optic nerve lesions: an underestimated cause of silent retinal atrophy in MS. Neurology 94(23):e2468–e2478PubMedCrossRef
6.
Barboni P, Savini G, Valentino ML et al (2005) Retinal nerve fiber layer evaluation by optical coherence tomography in leber’s hereditary optic neuropathy. Ophthalmology 112:120–126PubMedCrossRef
7.
Barboni P, Carbonelli M, Savini G et al (2010) Natural history of Leber’s hereditary optic neuropathy: longitudinal analysis of the retinal nerve fibre layer by optical coherence tomography. Ophthalmology 117:623–627PubMedCrossRef
8.
Han J, Byun MK, Lee J et al (2015) Longitudinal analysis of retinal nerve fiber layer and ganglion cell-inner plexiform layer thickness in ethambutol-induced optic neuropathy. Graefes Arch Clin Exp Ophthalmol 253(12):2293–2299PubMedCrossRef
9.
Burkholder BM, Osborne B, Loguidice MJ et al (2009) Macular volume determined by optical coherence tomography as a measure of neuronal loss in multiple sclerosis. Arch Neurol 66:1366–1372PubMedCrossRef
10.
Gelfand JM, Nolan R, Schwartz DM et al (2012) Microcystic macular oedema in multiple sclerosis is associated with disease severity. Brain 135:1786–1793PubMedPubMedCentralCrossRef
11.
Kessel L, Hamann S, Wegener M, Tong J, Fraser CL (2018) Microcystic macular oedema in optic neuropathy: case series and literature review. Clin Exp Ophthalmol 46(9):1075–1086PubMedCrossRef
12.
Abegg M, Dysli M, Wolf S, Kowal J, Dufour P, Zinkernagel M (2014) Microcystic macular edema: retrograde maculopathy caused by optic neuropathy. Ophthalmology 121:142–149PubMedCrossRef
13.
Wolff B, Azar G, Vasseur V, Sahel JA, Vignal C, Mauget-Faysse M (2014) Microcystic changes in the retinal internal nuclear layer associated with optic atrophy: a prospective study. J Ophthalmol 2014:395189PubMedPubMedCentralCrossRef
14.
Pott JW, de Vries-Knoppert WA, Petzold A (2016) The prevalence of microcystic macular changes on optical coherence tomography of the macular region in optic nerve atrophy of non-neuritis origin: a prospective study. Br J Ophthalmol 100:216–221PubMedCrossRef
15.
16.
Suda K, Akagi T, Nakanishi H et al (2018) Evaluation of structure-function relationships in longitudinal changes of glaucoma using the spectralis oct follow-up mode. Sci Rep 8(1):17158PubMedPubMedCentralCrossRef
17.
Garway-Heath DF, Poinoosawmy D, Fitzke FW, Hitchings RA (2000) Mapping the visual field to the optic disc in normal tension glaucoma eyes. Ophthalmology 107:1809–1815PubMedCrossRef
18.
Nakanishi H et al (2016) Clustering of combined 24–2 and 10–2 visual field grids and their relationship with circumpapillary retinal nerve fiber layer thickness. Investig Ophthalmol Vis Sci 57:3203–3210CrossRef
19.
Kim JH, Lee HS, Kim NR, Seong GJ, Kim CY (2014) Relationship between visual acuity and retinal structures measured by spectral domain optical coherence tomography in patients with open-angle glaucoma. Investig Ophthalmol Vis Sci 55(8):4801–4811CrossRef
20.
Soltan-Sanjari M, Parvaresh MM, Maleki A, Ghasemi-Falavarjani K, Bakhtiari P (2008) Correlation between retinal nerve fiber layer thickness by optical coherence tomography and perimetric parameters in optic atrophy. J Ophthalmic Vis Res 3(2):91–94PubMedPubMedCentral
21.
Rebolleda G, Sánchez-Sánchez C, González-López JJ, Contreras I, Muñoz-Negrete FJ (2015) Papillomacular bundle and inner retinal thicknesses correlate with visual acuity in nonarteritic anterior ischemic optic neuropathy. Investig Ophthalmol Vis Sci 56(2):682–692CrossRef
22.
Park JY, Choi J, Oh WH, Kim JS (2016) Influence of RNFL thickness on visual acuity and visual field in bilateral temporal optic atrophy. J Korean Ophthalmol Soc 57(6):969–976CrossRef
23.
Kim BG, Park JY, Oh WH, Choi J (2020) Retinal ganglion cell layer thicknesses and visual functions in patients with bilateral temporal optic atrophy. J Korean Ophthalmol Soc 61(1):92–100CrossRef
24.
Heidelberg Engineering GmbH (2016) Spectralis HRA + OCT User manual software version 6.5 Articl No. 97290–011 INT.AE 16. Heidelberg
25.
Ctori I, Huntjens B (2015) Repeatability of foveal measurements using spectralis optical coherence tomography segmentation software. PLoS ONE 10(6):e0129005PubMedPubMedCentralCrossRef
26.
Atan D (2020) Challenges and opportunities in the diagnosis of nutritional optic neuropathy. Expert Rev Ophthalmol 15(2):67–70CrossRef
27.
28.
Chan NCY, Chan CKM (2018) The role of optical coherence tomography in the acute management of neuro-ophthalmic diseases. Asia Pac J Ophthalmol (Phila) 7(4):265–270
29.
Tsai RK, Lee YH (1997) Reversibility of ethambutol optic neuropathy. J Ocul Pharmacol Ther 13(5):473–477PubMedCrossRef
30.
Beck RW, Cleary PA, Backlund JC (1994) The course of visual recovery after optic neuritis. Experience of the optic neuritis treatment trial. Ophthalmology 101:1771–1778PubMedCrossRef
31.
Takada R, Takagi M, Oshima A, Miki A, Usui T, Hasegawa S, Abe H (2005) Delayed visual recovery from severe ethambutol optic neuropathy in two patients with atypical mycobacterium infection. Neuro Ophthalmology 29:187–193CrossRef
32.
Lamirel C, Newman NJ, Biousse V (2010) Optical coherence tomography (OCT) in optic neuritis and multiple sclerosis. Rev Neurol (Paris) 166(12):978–986CrossRef
33.
Pro MJ, Pons ME, Liebmann JM et al (2006) Imaging of the optic disc and retinal nerve fiber layer in acute optic neuritis. J Neurol Sci 250(1–2):114–119PubMedCrossRef
34.
Barboni P, Carbonelli M, Savini G et al (2010) Natural history of Leber’s hereditary optic neuropathy: longitudinal analysis of the retinal nerve fiber layer by optical coherence tomography. Ophthalmology 117:623–627PubMedCrossRef
35.
Tieger MG, Hedges TR III, Ho J et al (2017) Ganglion cell complex loss in chiasmal compression by brain tumors. J Neuro Ophthalmol 37(1):7–12CrossRef
36.
Kerrigan-Baumrind LA, Quigley HA, Pease ME, Kerrigan DF, Mitchell RS (2000) Number of ganglion cells in glaucoma eyes compared with threshold visual field tests in the same persons. Investig Ophthalmol Vis Sci 41(3):741–748
37.
Nieves-Moreno M, Martínez-de-la-Casa JM, Cifuentes-Canorea P et al (2017) Normative database for separate inner retinal layers thickness using spectral domain optical coherence tomography in Caucasian population. PLoS ONE 12(7):e0180450PubMedPubMedCentralCrossRef
38.
Nolan-Kenney RC, Liu M, Akhand O et al (2019) Optimal intereye difference thresholds by optical coherence tomography in multiple sclerosis: an international study. Ann Neurol 85(5):618–629PubMedCrossRef
39.
Coric D, Balk LJ, Uitdehaag BMJ, Petzold A (2017) Diagnostic accuracy of optical coherence tomography inter-eye percentage difference for optic neuritis in multiple sclerosis. Eur J Neurol 24(12):1479–1484PubMedCrossRef
40.
Sigler EJ (2014) Microcysts in the inner nuclear layer, a nonspecific SD-OCT sign of cystoid macular edema. Investig Ophthalmol Vis Sci 55(5):3282–3284CrossRef
41.
42.
43.
Kashani AH, Zimmer-Galler IE, Shah SM et al (2010) Retinal thickness analysis by race, gender, and age using Stratus OCT. Am J Ophthalmol 149(3):496-502.e1PubMedCrossRef
44.
Kelty PJ, Payne JF, Trivedi RH, Kelty J, Bowie EM, Burger BM (2008) Macular thickness assessment in healthy eyes based on ethnicity using Stratus OCT optical coherence tomography. Investig Ophthalmol Vis Sci 49(6):2668–2672CrossRef
45.
Khawaja AP, Chua S, Hysi PG et al (2020) Comparison of associations with different macular inner retinal thickness parameters in a large cohort: the uk biobank. Ophthalmology 127(1):62–71PubMedCrossRef
46.
Hu H, Jiang H, Gameiro GR, Hernandez J, Delgado S, Wang J (2019) Focal Thickness Reduction of the Ganglion Cell-Inner Plexiform Layer Best Discriminates Prior Optic Neuritis in Patients With Multiple Sclerosis. Invest Ophthalmol Vis Sci 60(13):4257–4269PubMedPubMedCentralCrossRef
Metadata
Title
Posterior segment spectral domain oct in the differential diagnosis of bilateral temporal optic neuropathy and its correlation with visual acuity
Authors
Tom Buelens
Jean-François Fils
François Willermain
Publication date
09-07-2022
Publisher
Springer Netherlands
Published in
International Ophthalmology / Issue 12/2022
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-022-02408-0

Other articles of this Issue 12/2022

Normative measurements of orbital structures by magnetic resonance imaging

Histological and molecular characterization of glaucoma model induced by one or two injections of microbeads to the anterior chamber of mice

Changes in effective optical zone after small-incision lenticule extraction in high myopia

Long-term evaluation of posterior corneal surface parameters after accelerated corneal cross-linking with a comparison with uncross-linked keratoconic eyes

Most nonpathological eyes present a small area of hyperreflective Henle’s fiber layer on pupil-centered optical coherence tomography

Choroidal structural alterations in diabetic patients in association with disease duration, HbA1c level, and presence of retinopathy