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Current Cardiology Reports

Integrating Prime Editing and Cellular Reprogramming as Novel Strategies for Genetic Cardiac Disease Modeling and Treatment

  • Open Access
  • 11-09-2024
  • Regenerative Medicine (SM Wu, Section Editor)
Published in:
Authors
Bing Yao
Zhiyong Lei
Manuel A. F. V. Gonçalves
Joost P. G. Sluijter
Published in
Current Cardiology Reports | Issue 11/2024

Abstract

Purpose of review

This review aims to evaluate the potential of CRISPR-based gene editing tools, particularly prime editors (PE), in treating genetic cardiac diseases. It seeks to answer how these tools can overcome current therapeutic limitations and explore the synergy between PE and induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) for personalized medicine.

Recent findings

Recent advancements in CRISPR technology, including CRISPR-Cas9, base editors, and PE, have demonstrated precise genome correction capabilities. Notably, PE has shown exceptional precision in correcting genetic mutations. Combining PE with iPSC-CMs has emerged as a robust platform for disease modeling and developing innovative treatments for genetic cardiac diseases.

Summary

The review finds that PE, when combined with iPSC-CMs, holds significant promise for treating genetic cardiac diseases by addressing their root causes. This approach could revolutionize personalized medicine, offering more effective and precise treatments. Future research should focus on refining these technologies and their clinical applications.
Title
Integrating Prime Editing and Cellular Reprogramming as Novel Strategies for Genetic Cardiac Disease Modeling and Treatment
Authors
Bing Yao
Zhiyong Lei
Manuel A. F. V. Gonçalves
Joost P. G. Sluijter
Publication date
11-09-2024
Publisher
Springer US
Published in
Current Cardiology Reports / Issue 11/2024
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-024-02118-2
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This content is intended for healthcare professionals outside of the UK.

Independent Medical Education Grant:
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Image Credits
Abstract graphic of layered, concentric circular shapes in bright green, pink, blue, and purple on a dark blue background. The rings and segments form a complex radial pattern without text/© Springer Health+ IME