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European Journal of Nutrition
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Open Access 09-07-2022 | Insulins | Original Contribution

RETRACTED ARTICLE: The impact of vitamin A supplementation on thyroid function and insulin sensitivity: implication of deiodinases and phosphoenolpyruvate carboxykinase in male Wistar rats

Authors: Samar R. Saleh, Rania Zaki, Radwa Hassan, Mohamed A. El-Kersh, Mohamed M. El-Sayed, Alshimaa A. Abd Elmoneam

Published in: European Journal of Nutrition | Issue 8/2022

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Abstract

Purpose

Vitamin A is an essential nutrient with vital biological functions. The present study investigated the effect of different doses of vitamin A palmitate at different time intervals on thyroid hormones and glycemic markers.

Methods

Male rats were administrated vitamin A palmitate at different doses (0, 0.7, 1.5, 3, 6, and 12 mg/kg, oral) and samples were collected at different time intervals of 2, 4, and 6 weeks. The levels of vitamin A, thyroid hormones (T3, T4, and TSH), deiodinases (Dio1 and Dio3), glycemic markers (blood insulin and fasting glucose levels, HOMA IR and HOMA β), retinol-binding protein 4 (RBP4) and the gluconeogenic enzyme phosphoenolpyruvate carboxykinase (PEPCK) were measured.

Results

The findings demonstrated that long-term supplementation with high doses of vitamin A palmitate resulted in hypothyroidism (lower T3 and T4 levels and elevated TSH levels) as well as upregulation of Dio1 and Dio3 expression levels. This effect was associated with elevated glucose and insulin levels, enhanced HOMA IR, and decreased HOMA B index. In addition, prolonged vitamin A supplementation significantly increased RBP4 levels that upregulated the expression of PEPCK.

Conclusion

High doses of vitamin A supplementation increased the risk of hypothyroidism, modulated insulin sensitivity, and over a long period, increased the incidence of type 2 diabetes mellitus associated with oxidative stress and hepatitis.
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Metadata
Title
RETRACTED ARTICLE: The impact of vitamin A supplementation on thyroid function and insulin sensitivity: implication of deiodinases and phosphoenolpyruvate carboxykinase in male Wistar rats
Authors
Samar R. Saleh
Rania Zaki
Radwa Hassan
Mohamed A. El-Kersh
Mohamed M. El-Sayed
Alshimaa A. Abd Elmoneam
Publication date
09-07-2022
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Nutrition / Issue 8/2022
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI
https://doi.org/10.1007/s00394-022-02945-5

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