Skip to main content

Advanced Search

Projected result for your current search:: 0

Search Operators:

You can use operators in your search query to narrow down your results even more. Click on the search operator to see an explanation of how it works.
Finds documents with exactly this word group, in exactly this word order and spelling (e.g. "employer branding").
Finds documents with both search terms (e.g. sales AND bonus).
Finds documents with one or the other search term (e.g. porsche OR volkswagen).
Finds documents with all search terms. Blank space is understood as AND (e.g. man robot production).
Finds documents with no appearance of the word behind NOT (e.g. ford NOT "harrison ford").
Finds documents where the search term is mentioned at least "n" times."n" may be any number (e.g. COUNT(gear)>8).
Finds documents with both search terms in any word order, permitting "n" words as a maximum distance between them. Best choose between 15 and 30 (e.g. NEAR(recruit, professionals, 20)).
Finds documents with the search term in word versions or composites. The asterisk * marks whether you wish them BEFORE, BEHIND, or BEFORE and BEHIND the search term (e.g. lightweight*, *lightweight, *lightweight*).
Finds documents with the search term in different spellings. "?" allows only one character (e.g. organi?ation).
Special characters are understood as AND (e.g. Miller Bros. & Sons).
 Log in
Top
BMC Endocrine Disorders

The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and the risk of insulin resistance: results from the NHANES 2003–2016

  • Open Access
  • 01-12-2025
  • Insulins
  • Research
Published in:
Authors
BaoYing Li
YuLing Zha
Mi Deng
LuNa Niu
XueFei Li
RuoWei Zhu
Jing Tian
Lu Jing
Published in
BMC Endocrine Disorders | Issue 1/2025

Abstract

Background

The relationship between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR), as a novel lipid indicator, and insulin resistance (IR) remains unclear. This cross-sectional study aimed to identify the association between NHHR and the risk of IR.

Methods

Utilizing NHANES data from 2003 to 2016, 5,853 participants were eventually included. Triglyceride glucose index (TyG) was used as a marker to evaluate IR, and weighted logistic regression, trend test, restricted cubic spline and subgroup analysis were used to analyze the relationship between NHHR and the risk of IR.

Results

After adjusting for all relevant covariates, NHHR exhibited a significant positive correlation with TyG (OR = 3.44, 95% CI: 3.12–3.80, P < 0.001). The restricted cubic spline further proved that NHHR had nonlinear correlation with TyG. Subgroup analyses suggested distinct differences and cross-correlations between race and smoking status, and could provide reference for studies of multicharacteristic populations.

Conclusion

This cross-sectional study revealed a significant association between NHHR and the risk of IR. Elevated NHHR was associated with an increased risk of diminished insulin sensitivity and the risk of IR development, and these findings provided a clinical perspective for understanding the pathogenesis of IR from cholesterol accumulation.

Clinical trial number

Not applicable.
Title
The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and the risk of insulin resistance: results from the NHANES 2003–2016
Authors
BaoYing Li
YuLing Zha
Mi Deng
LuNa Niu
XueFei Li
RuoWei Zhu
Jing Tian
Lu Jing
Publication date
01-12-2025
Publisher
BioMed Central
Keywords
Insulins
Insulins
Published in
BMC Endocrine Disorders / Issue 1/2025
Electronic ISSN: 1472-6823
DOI
https://doi.org/10.1186/s12902-025-01982-5
This content is only visible if you are logged in and have the appropriate permissions.

Other articles of this Issue 1/2025

Relationship of comprehensive dietary antioxidant index and hypothyroidism risk: evidence from the National Health and Nutrition Examination Surveys 2007–2012

Revamped perspective on conventional interpretation: the foreboding prognostic significance of low-lateralization in inferior petrosal sinus sampling for diagnosis of Cushing’s disease

Adrenal response at the onset of type 1 diabetes mellitus in children and its association with acute metabolic and kidney complications

Incidence and predictors of diabetic kidney disease among type 2 diabetes mellitus adult patients in Ethiopia: a systematic review and meta-analysis

TyG-ABSI as a novel metabolic obesity indicator for carotid plaque: an explainable machine learning study using SHAP in low-income population

  • Open Access
  • Obesity
  • Original Research

Correlation between the first-trimester non-traditional lipid parameters with the risk of gestational diabetes mellitus in pregnancy

Keynote webinar | Spotlight on progress in colorectal cancer

CRC remains a major global health burden, but advances in screening, treatment, and lifestyle-based prevention continue to reshape clinical practice. Gain insights into how the latest research can be leveraged to optimize patient care across the CRC continuum.

Prof. Antoni Castells
Prof. Harpreet Wasan
Prof. Edward Giovannucci
Watch now

Keynote webinar | Spotlight on functional neurological disorder

FND perplexes and frustrates patients and physicians alike. Limited knowledge and insufficient awareness delays diagnosis and treatment, and many patients feel misunderstood and stigmatized. How can you recognize FND and what are the treatment options?

Prof. Mark Edwards
Watch now
Video
Image Credits
Colon cancer illustration/© (M) KATERYNA KON / SCIENCE PHOTO LIBRARY / Getty Images, Human brain illustration/© (M) CHRISTOPH BURGSTEDT / SCIENCE PHOTO LIBRARY / Getty Images