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Open Access 04-05-2024 | Insulins | Research article

Lipidomic signatures in Colombian adults with metabolic syndrome

Authors: María Fernanda Serna, Milton Fabián Suarez-Ortegón, Eliécer Jiménez-Charris, Isabella Echeverri, Mónica P. Cala, Mildrey Mosquera

Published in: Journal of Diabetes & Metabolic Disorders

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Abstract

Background and Aims

Metabolic syndrome (MetS) comprises a set of risk factors that contribute to the development of chronic and cardiovascular diseases, increasing the mortality rate. Altered lipid metabolism is associated with the development of metabolic disorders such as insulin resistance, obesity, atherosclerosis, and metabolic syndrome; however, there is a lack of knowledge about lipids compounds and the lipidic pathways associated with this condition, particularly in the Latin-American population. Innovative approaches, such as lipidomic analysis, facilitate the identification of lipid species related to these risk factors. This study aimed to assess the plasma lipidome in subjects with MetS.

Methods

This correlation study included healthy adults and adults with MetS. Blood samples were analyzed. The lipidomic profile was determined using an Agilent Technologies 1260 liquid chromatography system coupled to a Q-TOF 6545 quadrupole mass analyzer with electrospray ionization. The main differences were determined between the groups.

Results

The analyses reveal a distinct lipidomic profile between healthy adults and those with MetS, including increased concentrations of most identified glycerolipids -both triglycerides and diglycerides- and decreased levels of ether lipids and sphingolipids, especially sphingomyelins, in MetS subjects. Association between high triglycerides, waist circumference, and most differentially expressed lipids were found.

Conclusion

Our results demonstrate dysregulation of lipid metabolism in subjects with Mets, supporting the potential utility of plasma lipidome analysis for a deeper understanding of MetS pathophysiology.
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Literature
4.
6.
go back to reference Monnerie S, Comte B, Ziegler D, Morais JA, Pujos-Guillot E, Gaudreau P. Metabolomic and Lipidomic Signatures of Metabolic Syndrome and its Physiological Components in Adults: A Systematic Review. Scientific Reports. 2020;10(1):669, 2020/01/20. doi: https://doi.org/10.1038/s41598-019-56909-7. Monnerie S, Comte B, Ziegler D, Morais JA, Pujos-Guillot E, Gaudreau P. Metabolomic and Lipidomic Signatures of Metabolic Syndrome and its Physiological Components in Adults: A Systematic Review. Scientific Reports. 2020;10(1):669, 2020/01/20. doi: https://​doi.​org/​10.​1038/​s41598-019-56909-7.
14.
15.
go back to reference Yero J, Iglesias Á, González D. Utilidad del índice HOMA-IR con una sola determinación de insulinemia para diagnosticar resistencia insulínica. Revista Cubana de Endocrinología, 2011;22:69–77, 08/01. Yero J, Iglesias Á, González D. Utilidad del índice HOMA-IR con una sola determinación de insulinemia para diagnosticar resistencia insulínica. Revista Cubana de Endocrinología, 2011;22:69–77, 08/01.
36.
go back to reference Márquez-Sandoval F, Macedo-Ojeda G, Viramontes-Hörner D, Fernández Ballart JD, Salas Salvadó J, Vizmanos B. The prevalence of metabolic syndrome in Latin America: a systematic review, (in eng), Public Health Nutr, 2011;14(10):1702–13. doi: https://doi.org/10.1017/s1368980010003320. Márquez-Sandoval F, Macedo-Ojeda G, Viramontes-Hörner D, Fernández Ballart JD, Salas Salvadó J, Vizmanos B. The prevalence of metabolic syndrome in Latin America: a systematic review, (in eng), Public Health Nutr, 2011;14(10):1702–13. doi: https://​doi.​org/​10.​1017/​s136898001000332​0.
48.
go back to reference Mahjoub S, Masrour-Roudsari J. Role of oxidative stress in pathogenesis of metabolic syndrome, (in eng), Caspian J Internal Med. 2012;3(1):386–396, Winter. Mahjoub S, Masrour-Roudsari J. Role of oxidative stress in pathogenesis of metabolic syndrome, (in eng), Caspian J Internal Med. 2012;3(1):386–396, Winter.
62.
go back to reference Stamler CJ, Breznan D, Neville TA, Viau FJ, Camlioglu E, Sparks DL. Phosphatidylinositol promotes cholesterol transport in vivo, (in eng). J Lipid Res. 2000;41(8):1214–21.CrossRefPubMed Stamler CJ, Breznan D, Neville TA, Viau FJ, Camlioglu E, Sparks DL. Phosphatidylinositol promotes cholesterol transport in vivo, (in eng). J Lipid Res. 2000;41(8):1214–21.CrossRefPubMed
Metadata
Title
Lipidomic signatures in Colombian adults with metabolic syndrome
Authors
María Fernanda Serna
Milton Fabián Suarez-Ortegón
Eliécer Jiménez-Charris
Isabella Echeverri
Mónica P. Cala
Mildrey Mosquera
Publication date
04-05-2024
Publisher
Springer International Publishing
Published in
Journal of Diabetes & Metabolic Disorders
Electronic ISSN: 2251-6581
DOI
https://doi.org/10.1007/s40200-024-01423-5
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