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Current Diabetes Reports

Effects of Nicotinamide Mononucleotide on Glucose and Lipid Metabolism in Adults: A Systematic Review and Meta-analysis of Randomised Controlled Trials

  • Open Access
  • 01-12-2025
  • Insulins
  • REVIEW
Published in:
Authors
Feng Chen
Disheng Zhou
Alice Pik-Shan Kong
Nga Ting Yim
Siyu Dai
Yu Nan Chen
Lai Ling Hui
Published in
Current Diabetes Reports | Issue 1/2025

Abstract

Purpose of Review

Supplementation of nicotinamide mononucleotides (NMN) has been claimed to improve metabolic function. We reviewed human randomised controlled trials (RCTs) of NMN to evaluate its effect on markers of glucose and lipid metabolism.

Recent Findings

Eight RCTs on NMN (dosage ranged 250–2000 mg/d for a duration of 14 days to 12 weeks) involving a total of 342 middle-age/older adults (49% females, mainly non-diabetic) reporting at least one outcome on glucose control or lipid profile published in 2021–2023 were reviewed. The random-effects meta-analyses indicated no significant benefit of NMN on fasting glucose, fasting insulin, glycated hemoglobin, homeostatic model assessment for insulin resistance and lipid profile.

Summary

Based on the small number of RCTs involving mainly relatively healthy adults, short-term supplementation of NMN of 250-2000 mg/d did not show significantly positive impacts on glucose control and lipid profile.
Title
Effects of Nicotinamide Mononucleotide on Glucose and Lipid Metabolism in Adults: A Systematic Review and Meta-analysis of Randomised Controlled Trials
Authors
Feng Chen
Disheng Zhou
Alice Pik-Shan Kong
Nga Ting Yim
Siyu Dai
Yu Nan Chen
Lai Ling Hui
Publication date
01-12-2025
Publisher
Springer US
Keywords
Insulins
Insulins
Published in
Current Diabetes Reports / Issue 1/2025
Print ISSN: 1534-4827
Electronic ISSN: 1539-0829
DOI
https://doi.org/10.1007/s11892-024-01557-z
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