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Published in: Digestive Diseases and Sciences 2/2023

21-01-2023 | Infliximab | Multicenter Seminars: IBD (MUSE: IBD)

Opportunistic Knocks: A Gardener with Ulcerative Colitis and New Pulmonary Nodules

Authors: Andrew Canakis, Sindhura Kolachana, Van K. Holden, Raymond K. Cross

Published in: Digestive Diseases and Sciences | Issue 2/2023

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Excerpt

Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disease that is usually classified either ulcerative colitis (UC) or Crohn’s disease (CD). Though its exact pathogenesis remains unknown, there have been remarkable therapeutic advances with the widespread use of biologic therapies. Tumor necrosis factor-alpha (TNF) inhibitors, such as infliximab and adalimumab, can be used for UC and CD as a therapy to blunt the cytokine response produced by macrophages in the setting of endotoxins and oxidative stress [1]. Nevertheless, by disrupting the host’s natural defense system, these immunosuppressive therapies increase the risk of opportunistic infections, which are associated with higher morbidity and mortality in this patient population. It is therefore paramount to recognize such infections and treat accordingly in a timely manner. In this case, we report an opportunistic infection of pulmonary Histoplasmosis capsulatum in a patient receiving biologic therapy who developed systemic symptoms with new pulmonary nodules. …
Literature
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Metadata
Title
Opportunistic Knocks: A Gardener with Ulcerative Colitis and New Pulmonary Nodules
Authors
Andrew Canakis
Sindhura Kolachana
Van K. Holden
Raymond K. Cross
Publication date
21-01-2023
Publisher
Springer US
Published in
Digestive Diseases and Sciences / Issue 2/2023
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-022-07785-1

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