Issue 2/2025
Content (25 Articles)
Prooxidant state in anticancer drugs and prospect use of mitochondrial cofactors and anti-inflammatory agents in cancer prevention
- Review
Giovanni Pagano, Alex Lyakhovich, Philippe J. Thomas, Federico V. Pallardó Catalayud, Luca Tiano, Adriana Zatterale, Marco Trifuoggi
Unraveling the hormonal approaches for the treatment of rheumatoid arthritis and its complementary interventions
- Rheumatoid Arthritis
- Review
Priya Sharad Waghmare, Deepika Kaushik, Emel Oz, Charalampos Proestos, Fatih Oz, Mukul Kumar
Targeting the NLRP3 inflammasome as a novel therapeutic target for osteoarthritis
- Osteoarthrosis
- Review
Varnita Karmakar, Mayukh Chain, Ankit Majie, Arya Ghosh, Pallav Sengupta, Sulagna Dutta, Papiya Mitra Mazumder, Bapi Gorain
Cyclosporin for the treatment of Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN): a systematic review of observational studies and clinical trials focusing on single therapy, combination therapy, and comparative assessments
- Toxic Epidermal Necrolysis
- Review
Amirhossein Nazerian, Alireza Jafarzadeh, Sadaf Salehi, Mobina Ghasemi, Azadeh Goodarzi
The multifaceted anticancer potential of luteolin: involvement of NF-κB, AMPK/mTOR, PI3K/Akt, MAPK, and Wnt/β-catenin pathways
- Review
Deepika Singh, Gaurav Shukla
Naturally derived bioactive compounds as precision modulators of immune and inflammatory mechanisms in psoriatic conditions
- Open Access
- Vulgar Psoriasis
- Review
Ada Radu, Delia Mirela Tit, Laura Maria Endres, Andrei-Flavius Radu, Cosmin Mihai Vesa, Simona Gabriela Bungau
Repositioning anthelmintics for the treatment of inflammatory-based pathological conditions
- Ivermectin
- Review
Débora Caroline do Nascimento Rodrigues, Jhonatas Cley Santos Porto, Ingredy Lopes dos Santos, José Ivo Araújo Beserra Filho, Paulo Michel Pinheiro Ferreira
Examining the role of antioxidant supplementation in mitigating oxidative stress markers in Alzheimer’s disease: a comprehensive review
- Alzheimer Disease
- Review
Mahmood Jawad, Subasini Uthirapathy, Farag M. A. Altalbawy, Enwa Felix Oghenemaro, Jasur Rizaev, Madan Lal, Mamdouh Eldesoqui, Naveen Sharma, Atreyi Pramanik, Ahmed Khudhair AL-Hamairy
Connecting dots: Preclinical foundations to clinical realities of PDE4 inhibitors in Alzheimer's disease
- Alzheimer Disease
- Review
Shilpa Kumari, Kajal Bagri, Rahul Deshmukh
Advancements in nose-to-brain drug targeting for Alzheimer’s disease: a review of nanocarriers and clinical insights
- Alzheimer Disease
- Review
Kumari Komal, Rashmi Ghosh, Debayan Sil, Rohit Sharma, Sourabh Kumar, Prachi pandey, Manish Kumar
The neuroprotective role of volatile oils: insights into chemical profiles, characteristics, neurochemical mechanisms, and preclinical studies in Alzheimer's disease
- Alzheimer Disease
- Review
Meghraj Suryawanshi, Pranjal Gujarathi, Bhupendra Prajapati, Kuldeep Vinchurkar, Piyush Gujarathi
Exploring the role of HIF-1α on pathogenesis in Alzheimer’s disease and potential therapeutic approaches
- Alzheimer Disease
- Review
Pratyush Porel, Kanchan Bala, Khadga Raj Aran
Shedding light on microglial dysregulation in Alzheimer’s disease: exploring molecular mechanisms and therapeutic avenues
- Alzheimer Disease
- Review
Vanshu Bhardwaj, Sneha Kumari, Rishika Dhapola, Prajjwal Sharma, Samir Kumar Beura, Sunil Kumar Singh, Balachandar Vellingiri, Dibbanti HariKrishnaReddy
Pathophysiological role of high mobility group box-1 signaling in neurodegenerative diseases
- Huntington Disease
- Review
Vishal Kumar, Puneet Kumar
Neuroprotective effects of phytochemicals through autophagy modulation in ischemic stroke
- Stroke
- Review
Amir Mahmoud Ahmadzadeh, Ali Mohammad Pourbagher-Shahri, Fatemeh Forouzanfar
Polyphenols mitigating inflammatory mechanisms in inflammatory bowel disease (IBD): focus on the NF-ƙB and JAK/STAT pathways
- Open Access
- Inflammatory Bowel Disease
- Review
Elysha Nur Ismail, Noraina Zakuan, Zulkefley Othman, Sharmili Vidyadaran, Hussin Mohammad, Reezal Ishak
Targeting high-mobility-group-box-1-mediated inflammation: a promising therapeutic approach for myocardial infarction
- Myocardial Infarction
- Review
Shrutika Date, Lokesh Kumar Bhatt
Therapeutic potential of plant polyphenols in acute pancreatitis
- Acute Pancreatitis
- Review
Chengu Niu, Jing Zhang, Patrick I. Okolo 3rd
Therapeutic efficacy of brown propolis from Araucaria sp. in modulating rheumatoid arthritis
- Arthritis
- Original Article
Poliana Marques Pereira, Silvio de Almeida-Junior, Naomi Nalini de Melo Taveira, Eveline Maria de Melo, Mario Ferreira Conceição Santos, Lilian Cristina Gomes do Nascimento, Marcela Aldrovani Rodrigues, Jennyfer A. Aldana-Mejía, Marcio Luís Andrade e Silva, Sérgio Ricardo Ambrósio, Jairo Kenupp Bastos, Samir A. Ross, Ricardo Andrade Furtado
From metabolomics to therapeutics: identifying causal metabolites and potential drugs for the treatment of osteoarthritis
- Osteoarthrosis
- Original Article
Heng Li, Jingyan Sun, Jiewen Zhang, Yang Chen, Yiwei Zhao, Ruomu Cao, Ning Kong, Xudong Duan, Huanshuai Guan, Run Tian, Kunzheng Wang, Pei Yang
Inhibition of alternative complement system and prolyl hydroxylase ameliorates anaemia of inflammation
- Erythropoietin
- Original Article
Vishal J. Patel, Amit A. Joharapurkar, Samadhan G. Kshirsagar, Maulik S. Patel, Hardikkumar H. Savsani, Milan H. Rakhasiya, Harshad S. Dodiya, Mukul R. Jain
Role of intravenous vitamin C on outcomes in hospitalized patients with moderate or severe COVID-19: a real life data of Turkish patients
- COVID-19
- Original Article
Burak Uz, Özgür İnce, Can Gümüş, Feyzi Gökosmanoğlu, Emrah Gökay Özgür, Gülnaz Nural Bekiroğlu
Anorexigenic and anti-inflammatory signaling pathways of semaglutide via the microbiota–gut––brain axis in obese mice
- Semaglutide
- Original Article
Rodrigo Soares da Silva, Igor Henrique Rodrigues de Paiva, Ingrid Prata Mendonça, José Roberto Botelho de Souza, Norma Lucena-Silva, Christina Alves Peixoto
Quercetin alleviates neonatal hypoxic-ischaemic brain injury by rebalancing microglial M1/M2 polarization through silent information regulator 1/ high mobility group box-1 signalling
- Hypoxic-Ischaemic Encephalopathy
- Original Article
Zhaoyan Chen, Fei Ruan, Di Wu, Xiaoping Yu, Yaqing Jiang, Wei Bao, Haicheng Wen, Jing Hu, Haidi Bi, Liping Chen, Kai Le
Evaluating diclofenac’s risks in COVID-19: strategies for mitigating adverse outcomes
- Diclofenac
- Commentary
Chia Siang Kow, Dinesh Sangarran Ramachandram, Syed Shahzad Hasan, Kaeshaelya Thiruchelvam