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Inflammopharmacology

Issue 11/2025

Content (41 Articles)

Curcumin: multifaceted biological actions and therapeutic implications—a narrative review

  • Review

Behnam Ghorbani-nejad, Matin Baghani, Sajad Amiri, Nasim Agaei Delche, Mohammad Hossein Darijani, Motahareh Soltani, Alireza Nezami, Milad Rahimzadegan

Biochemical investigations, in silico study and targeted delivery aspects of plant phytosterols: β-sitosterol

Tejaswini V. Jagtap, Ashwini R. Madgulkar, Mangesh R. Bhalekar

Modulating inflammation and oxidative stress in rheumatoid arthritis: a systematic review of nutraceutical interventions

Camila Leiva-Castro, Ana M. Múnera-Rodríguez, Gádor Torres-Joya, Francisca Palomares-Jerez, Soledad López-Enríquez

Therapeutic potential of purpurin, a natural anthraquinone dye, in neuroprotection and neurological disorders

Aya M. Mustafa, Ghadir A. Sayed, Shymaa Hatem, Roxane Abdel-Gawad Moussa, Dina M. Hal, Mahmoud A. Mansour, Mohamed S. Abd El Hafeez

Asperuloside: an emerging therapeutic candidate for Parkinson’s disease through molecular mechanistic insights

Shiv Kumar Kushawaha, Kanika Vashisht, Himanshu Kumar, Mahendra Singh Ashawat, Ashish Baldi

Innovative polymer-based therapeutics targeting inflammation for responsive drug delivery in disease treatment

  • Review

Km Lipsi, Milind Pande

Nrf2 signaling in bone health: unlocking new avenues for osteoporosis management

Mitali P. Lavhale, Satish K. Mandlik, Vaibhav M. Shinde, Deepa S. Mandlik

Exploring herbal synergies in the management of rheumatoid arthritis: a multifaceted approach to inflammation and joint health

Shikhar Verma, Mitali Panchpuri, Vagish Dwibedi, Santosh Kumar Rath, Arti Devi

Neurodegeneration and aging: pathophysiology, diagnosis, and therapeutic targets

Abhay Thakur, Rahul Sharma, Rohit Sharma, Anjana Devi

Inflammation and immune biomarkers: new frontiers in understanding and managing diabetes complications

Polu Picheswara Rao, Shubham Mishra, Jaya Gupta, Manish Vyas, Malakapogu Ravindra Babu

URAT1 and GLUT9 as drug targets in gout: progress in transporter-directed therapies and delivery technologies

Soumya Mishra, Ranjit K. Harwansh, Rupa Mazumder

Targeting the senescence-associated secretory phenotype to modify osteoarthritis in aging

Muhammad Afzal, M. M. Rekha, Samir Sahoo, Surya Nath Pandey, Chandana Maji, Kavita Goyal, Haider Ali, Sachin Kumar Singh, Gaurav Gupta, Md Sadique Hussain

From infection to intervention: post-acute sequelae of SARS-CoV-2 infection and cardiovascular risk

Rufaida Wasim

Targeting the NLRP3 inflammasome with natural products for ischemia–reperfusion injury across organs: mechanisms, structure–activity relationships, and delivery innovations

Rajnish Kumar, Archna Singh, Shrishti Tripathi, Salahuddin, Mohd. Mustaqeem Abdullah

Enterogenic dementia: defining the gut–brain axis and the role of inflammatory bowel disease in cognitive impairment

Faisal Alshammari, Hayder M. Al-Kuraishy, Mustafa M. Shokr, Marios Papadakis, Athanasios Alexiou, Gaber El-Saber Batiha

Chloroquine protects against mesenteric ischemia: insights into the role of nitrergic and opioidergic systems

Seyed Amir Mahdi Emami, Amirabbas Mohammadi Hamaneh, Moein Ghasemi, Alireza Abdollahi, Kimiya Jouyban, Razieh Mohammad Jafari, Amir Hossein Abdolghaffari, Ahmad Reza Dehpour

Quinic acid alleviates inflammatory responses and oxidative stress in Freund’s complete adjuvant-induced arthritic rat model and associated risk factors of atherosclerosis

Iqra, Ali Sharif, Bushra Akhtar, Chuxiao Shao, Shuanghu Wang, Ayesha Younas

Impact of Psidium guajava bark extract on inflammatory biomarkers in Wistar rat models of inflammation

Eleazar Chukwuemeka Anorue, Amaechi L. Ogara, Parker Elijah Joshua, Divine Godswill Ibekwe, Anthony Ikechukwu Igbokwe

Nanoencapsulated Syzygium aromaticum oil alleviates acetic acid-induced ulcerative colitis in rats by influencing critical redox, NF-κB/iNOS, and Keap1/Nrf2/HO-1 signaling pathways

Gehad E. Elshopakey, Shaymaa Rezk, Ahmed Ateya, Tarek A. Elkhooly, Alaa A. Omar, Ali El-Far, Ekramy M. Elmorsy, Hala Magdy Anwer, Mona M. Elghareeb

Salvia argentea L. extract inhibits the production of NO, and pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α), alleviates the inflammatory response of LPS-induced macrophages cells, and reduces the CRP level on carrageenan-induced paw edema

Almonther Alhamedi, Tugce Demiroz Akbulut, Sura Baykan, Barış Gümüştaş, Ebru Sanci, Karrar Ali Mohammed Hasan Alsakini, Ayşe Nalbantsoy, Aylin Buhur, Altuğ Yavasoğlu, N. Ülkü Karabay Yavasoğlu

Genetic changes in regulatory immune cells induced by pramipexole and rotigotine: implications for the treatment of Parkinson’s disease

Diana Denisse Álvarez-Luquín, Adrián Guevara-Salinas, Edgar Sevilla-Reyes, Jorge Rosas-García, Miriam Bravo-Martinez, Gloria Erandi Pérez-Figueroa, Vera Teresa Vega-Angeles, Dafne Díaz-Rivera, Carlos Castellanos-Barba, Laura Adalid-Peralta

Boswellic acids as an adjunct therapy in Parkinson’s disease: a double-blind clinical trial investigating on its effects on motor symptoms and inflammatory markers

Somayyeh Shateri, Seyyed Hossein Khatami, Sajad Ehtiati, Mohammad Reza Talebzadeh, Sadegh Nikakhtar, Monir Hassani Parvar, Seyedeh Ozra Hosseini, Gholamali Shahidi, Amir Hossein Habibi, Farzaneh Salmani, Fatemeh Namvarjah, Ali Riazi, Abbas Tafakhori, Saeed Karima

L-carnitine as a novel approach for pain and inflammation relief in rheumatoid arthritis

Abdallah A. Eldisouky, Sahar K. Hegazy, Salwa Elmorsy Abd Elghany

Adjunctive zinc supplementation with methotrexate improves therapeutic outcomes in an animal model of arthritis

Mohammad Hasan, Manu Sharma, Abul Vafa, Mairaj Ahmed Ansari, Shakir Ali, Haider A. Khan

Clinical study evaluating the gastroprotective effect of carvedilol in patients with ischemic heart disease on aspirin therapy

Sarah M. Elkablawy, Aliaa E. Shaban, Tarek M. Mostafa

Fabrication of bergapten loaded microneedle patch and assessment of its anti-arthritic potential against complete Freund’s adjuvant induced arthritis in Wistar rat

Qadeer Ahmad, Ammara Saleem, Zulcaif Ahmad, Muhammad Furqan Akhtar

Kaempferol prevents Nrf2 from ubiquitin-mediated proteolysis to mitigate both NLRP3 inflammation and oxidative stress: implications for alleviating DSS-induced colitis in mice

Wentian Hua, Minrui Li, Ziwei Yan, Yingchao Wang, Xiang Zhou, Zhiwen Fu, Yi Wang, Shujing Zhang, Jing Qian

Resveratrol supplementation improves functional performance in knee osteoarthritis by upregulating sirtuin 1: a randomized study

Asima Karim, Haroon Ahmed Khan, Firdos Ahmad, Rizwan Qaisar

The potential protective effect of Empagliflozin against Cisplatin-induced ovarian damage via upregulation of SIRT1/Nrf2 and amelioration ER Stress

Magda E. El-Sayad, Sally E. Abu-Risha, Sarah S. El-sisi, Hanaa A. Ibrahim

Diallyl disulfide attenuates DSS-induced colonic fibrosis in mice by modulating gut microbiota and Nrf2 signaling

Shuangshuang Hai, Yan Chen, Meiyan Zhang, Weixin Liu, Xiaohong Sun

Unveiling the antioxidant and anti-inflammatory potentials of Gomphostigma virgatum and analyzing its phytochemical profile

  • Original Article

Emmanuel Mfotie Njoya, Gaetan T. Tabakam, Chika I. Chukwuma, Tshepiso J. Makhafola

Efficacy and safety of cyclosporine in colitis: An updated meta-analysis of randomized control trials (1998 to 2024)

Aqsa Mehreen, Faiza Batool, Uzma Azeem Awan, Shaista Aslam, Adnan Haider, Muneeb Ullah, Jin-Wook Yoo, Rida Fatima Saeed, Muhammad Naeem

Sodium hydrogen sulfide restores H2S-synthesizing and degrading enzymes to alleviate glial activation after traumatic brain injury in male mice

Farheen Nasir, Priyanka Yadav, Thamil Mani Sivanandam

Pretreatment with probiotics (Bacillus safensis NMCC-189 and Bacillus clausii) prevents epileptogenesis in mice via modulation of BBB integrity, oxidative stress, and neurotransmitter balance

Maryam Khan Sherwani, Jehan Zeb Khan, Shakira Ghazanfar, Fahim Hilal, Rimsha Noor, Muhammad Khalid Tipu

Anti-inflammatory potential of telmisartan compared to other antihypertensives: secondary outcomes from a randomized trial

Simi Bridjit Gomaz, Jaykaran Charan, Amal Mohandas, Pravesh Aggarwal, Deepak Kumar, Dharmveer Yadav, Ravindra Shukla, Sneha Ambwani, Rimple Jeet Kaur

Silybum marianum seeds mitigate pro-inflammatory functions of human neutrophils and alleviate ulcerative colitis in rats

Ahmed Kouki, Riadh Marrouchi, Abdelaziz Souli, Salwa Bouabdallah, Wafa Ferjani, Pham My-Chan Dang, Amadou Dicko, Jamel El-Benna, Mossadok Ben-Attia

Dual evaluation of Citrullus colocynthis fruit extract for anti-rheumatic activity: integrating in silico docking and in vivo murine RA model analysis

Jawad Ashfaq, Muti-Ur-Rehman Khan, Asim Aslam, Arfan Ahmad, Adeel Sattar, Waqas Ahmad

Phlomoides molucelloides (Bunge) Salmaki essential oil: a traditional remedy revitalized for modern antimicrobial challenges

Mansureh Ghavam, Gianluigi Bacchetta, Ines Castangia, Maria Letizia Manca

Evaluating pomegranate seed oil for potential topical applications: safety, anti-inflammatory activity and wound healing in skin cell models

  • Original Article

Eduardo M. Costa, Manuela Machado, Manuela Pintado, Sara Silva

Trypsin inhibitor isolated from the seeds of Inga laurina (sw.) Willd decreased inflammatory and nociceptive responses in mice

Iluska Senna Bonfá, Dalila dos Santos Lencina, Jéssica de Araújo Isaías Muller, Paloma Kênia de Moraes Berenguel Lossavaro, Mila Marluce Lima Fernandes, Joyce dos Santos Lencina, Gabriel Silvino de Oliveira Venâncio, Kamylla Fernanda Souza de Souza, Julia Lopes Ribeiro Fredo, Maria Inês Lenz Souza, Saulo Euclides Silva Filho, Edgar Julian Paredes Gamero, Ana Cristina Jocobowski, Maria Ligia Rodrigues Macedo, Mônica Cristina Toffoli Kadri

Ozone therapy for temporomandibular joint osteoarthritis: a comment on the mechanistic insights and clinical translation

DuJiang Yang, Jian Wu, Junjie Chen, Shuang Wang, Gaowen Gong, GuoYou Wang

Oct 25
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