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01-03-2025 | Inflammatory Rheumatic Diseases | Review

Thyroid disease as a comorbidity in inflammatory rheumatic diseases

Authors: Yuliya Fedorchenko, Marlen Yessirkepov, Bohdana Doskaliuk, Liubomyr Zaiats, Khaiyom Mahmudov

Published in: Rheumatology International | Issue 3/2025

Abstract

Thyroid disease is a common comorbidity in inflammatory rheumatic diseases (IRDs). It complicates disease management and treatment of IRDs. The interplay between thyroid disfunction and IRDs is confounded by shared autoimmune mechanisms and systemic inflammation. Available evidence suggests that rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and systemic sclerosis (SSc) are associated with an elevated risk of hypothyroidism, hyperthyroidism, and autoimmune thyroid disease (AITD). This review explores mechanisms of thyroid disease in IRDs, overviews implications for disease management, and highlights approaches to optimal patient outcomes. Recent studies point to the need for routine thyroid screening in high-risk IRD populations and justify therapies with anti-TNF-α and anti-IL-17 agents, targeting both thyroid disease and IRDs. This integrated management strategy is crucial for optimizing therapeutic approaches in overlapping autoimmune conditions.

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Title: Thyroid disease as a comorbidity in inflammatory rheumatic diseases
Authors: Yuliya Fedorchenko
Marlen Yessirkepov
Bohdana Doskaliuk
Liubomyr Zaiats
Khaiyom Mahmudov
Publication date: 01-03-2025
Publisher: Springer Berlin Heidelberg
Keywords: Inflammatory Rheumatic Diseases
Thyroid Disease
Hypothyroidism
Hyperthyroidism
Hashimoto Thyroiditis
Rheumatoid Arthritis
Systemic Lupus Erythematosus
Systemic Sclerosis
Ankylosing Spondylitis
Psoriatic Arthritis
Gout
Familial Mediterranean Fever
Published in: Rheumatology International / Issue 3/2025
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-025-05798-3

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