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BMC Medicine
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Open Access 26-03-2025 | Inflammatory Bowel Disease | Review

Gut virome and its implications in the pathogenesis and therapeutics of inflammatory bowel disease

Authors: Yushan Wu, Rui Cheng, Hao Lin, Lili Li, Yongbin Jia, Anna Philips, Tao Zuo, Hu Zhang

Published in: BMC Medicine | Issue 1/2025

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Abstract

Inflammatory bowel disease (IBD) refers to chronic, recurrent inflammatory intestinal disorders, primarily including Crohn’s disease (CD) and Ulcerative colitis (UC). Numerous studies have elucidated the importance of the gut microbiome in IBD. Recently, numerous studies have focused on the gut virome, an intriguing and enigmatic aspect of the gut microbiome. Alterations in the composition of phages, eukaryotic viruses, and human endogenous retroviruses that occur in IBD suggest potential involvement of the gut virome in IBD. Nevertheless, the mechanisms by which it maintains intestinal homeostasis and interacts with diseases are only beginning to be understood. Here, we thoroughly reviewed the composition of the gut virome in both healthy individuals and IBD patients, emphasizing the key viruses implicated in the onset and progression of IBD. Furthermore, the complex connections between the gut virome and the intestinal barrier, immunity, and gut microbiome were dissected to advance the interpretation of IBD pathogenesis. The updated discussion of the evidence regarding the gut virome will advance our knowledge in gut virome and chronic gastrointestinal diseases. Targeting the gut virome is a promising avenue for IBD treatment in future.
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Metadata
Title
Gut virome and its implications in the pathogenesis and therapeutics of inflammatory bowel disease
Authors
Yushan Wu
Rui Cheng
Hao Lin
Lili Li
Yongbin Jia
Anna Philips
Tao Zuo
Hu Zhang
Publication date
26-03-2025
Publisher
BioMed Central
Published in
BMC Medicine / Issue 1/2025
Electronic ISSN: 1741-7015
DOI
https://doi.org/10.1186/s12916-025-04016-y

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