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Inflammopharmacology

Zhumeria majdae essential oil attenuates TNBS-induced colitis in rats by regulating inflammatory and apoptotic pathways

Published in:
Authors
Helia Aghamiri
Afrooz Mohammadgholi-Beiki
Rojin Rashidian
Manijeh Motevalian
Parvaneh Rahimi-Moghaddam
Mohammad Sheibani
Majid Jafari-Sabet
Published in
Inflammopharmacology | Issue 6/2024

Abstract

Background and aim

Zhumeria majdae, a unique native plant of southern Iran, has been traditionally used to treat various health issues. Preclinical studies suggest its therapeutic potential for immunological and inflammatory disorders. This study investigates the effect of Z. majdae essential oil (ZMEO) on TNBS-induced colitis in rats, focusing on the NF-κB/p38 MAPK/Nrf-2 pathway.

Experimental procedure

Forty-eight male Wistar rats were used, with all groups except the sham group receiving a single intra-rectal dose of TNBS. Three different doses of ZMEO and also 1 mg/kg dexamethasone were administered orally for 2 weeks. Colon tissue was analyzed for ulcer index, histological changes, inflammatory cytokines, apoptotic factors, and levels of NF-κB, p38 MAPK, and Nrf-2.

Key results

GC-mass analysis identified 25 compounds with linalool (52.01%) and camphor (31.01%) as the major compounds in ZMEO. ZMEO ameliorated colon injuries, reduced ulcer index, and prevented the elevation of pro-inflammatory cytokines and pro-apoptotic proteins. It also increased the levels of IL-10 and Bcl-2 proteins. Furthermore, ZMEO decreased the expression of p-NF-κB and p38 MAPK while increasing the expression of pNrf-2.

Conclusions

ZMEO mitigates colon damage associated with IBD by suppressing inflammatory cytokines and pro-apoptotic proteins possibly through modulating the NF-κB/p38 MAPK/Nrf-2 signaling pathway.

Graphical abstract

Title
Zhumeria majdae essential oil attenuates TNBS-induced colitis in rats by regulating inflammatory and apoptotic pathways
Authors
Helia Aghamiri
Afrooz Mohammadgholi-Beiki
Rojin Rashidian
Manijeh Motevalian
Parvaneh Rahimi-Moghaddam
Mohammad Sheibani
Majid Jafari-Sabet
Publication date
23-09-2024
Publisher
Springer International Publishing
Published in
Inflammopharmacology / Issue 6/2024
Print ISSN: 0925-4692
Electronic ISSN: 1568-5608
DOI
https://doi.org/10.1007/s10787-024-01574-0
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