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01-12-2025 | Inflammatory Bowel Disease

Selected Use of Complementary and Alternative Medicine (CAM) Agents in IBD

Authors: Monica Dzwonkowski, Janak Bahirwani, Samantha Rollins, Alicia Muratore, Vikram Christian, Yecheskel Schneider

Published in: Current Gastroenterology Reports | Issue 1/2025

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Abstract

Purpose of Review

Inflammatory bowel disease (IBD) can cause significant psychological, physical, and economic burdens on patients and healthcare systems. Studies show over one-fifth of patients will seek nontraditional methods of treatment for managing their symptoms. Understanding the benefits - and potential harms - of these therapies is important to provide holistic and evidence-based care to our IBD patients.

Recent Findings

In this review, we present several studied herbal therapies for the management of both Crohn’s disease and ulcerative colitis. These include cannabinoids, Tripterygium wilfordii, Chios mastic gum, Boswellia serrata, Indigo Naturalis, curcumin, resveratrol, and Zingiber officinale. While these herbal remedies have been shown to have anti-inflammatory effects and positive outcomes in IBD patients, larger scale studies are lacking and the use may be limited by bioavailability, lack of standardization of formulations, and adverse reactions.

Summary

In reviewing the literature, we discuss the current data available including benefits, adverse reactions, and considerations for use surrounding several of the more common herbal remedies used for IBD.
Literature
15.
go back to reference Naftali T, Lev LB, Yablecovitch D, Half E, Konikoff FM. Treatment of Crohn’s disease with cannabis: an observational study. Isr Med Assoc J IMAJ. 2011;13(8):455–8.PubMed Naftali T, Lev LB, Yablecovitch D, Half E, Konikoff FM. Treatment of Crohn’s disease with cannabis: an observational study. Isr Med Assoc J IMAJ. 2011;13(8):455–8.PubMed
18.
go back to reference Naftali T, Bar-Lev Schleider L, Dotan I, Lansky EP, Sklerovsky Benjaminov F, Konikoff FM. Cannabis induces a clinical response in patients with Crohn’s disease: a prospective placebo-controlled study. Clin Gastroenterol Hepatol off Clin Pract J Am Gastroenterol Assoc. 2013;11(10):1276–e12801. https://doi.org/10.1016/j.cgh.2013.04.034.CrossRef Naftali T, Bar-Lev Schleider L, Dotan I, Lansky EP, Sklerovsky Benjaminov F, Konikoff FM. Cannabis induces a clinical response in patients with Crohn’s disease: a prospective placebo-controlled study. Clin Gastroenterol Hepatol off Clin Pract J Am Gastroenterol Assoc. 2013;11(10):1276–e12801. https://​doi.​org/​10.​1016/​j.​cgh.​2013.​04.​034.CrossRef
30.
go back to reference Tao Q, song, Ren J an, Ji Z ling, Li Jsheng, Wang X bo, Jiang X. hua. [Maintenance effect of polyglycosides of Tripterygium wilfordii on remission in postoperative Crohn disease]. Zhonghua Wei Chang Wai Ke Za Zhi Chin J Gastrointest Surg. 2009;12(5):491–493. Tao Q, song, Ren J an, Ji Z ling, Li Jsheng, Wang X bo, Jiang X. hua. [Maintenance effect of polyglycosides of Tripterygium wilfordii on remission in postoperative Crohn disease]. Zhonghua Wei Chang Wai Ke Za Zhi Chin J Gastrointest Surg. 2009;12(5):491–493.
34.
go back to reference Papada E, Gioxari A, Amerikanou C, et al. Regulation of faecal biomarkers in inflammatory bowel disease patients treated with oral mastiha (Pistacia lentiscus) supplement: a double-blind and placebo-controlled randomised trial. Phytother Res PTR. 2019;33(2):360–9. https://doi.org/10.1002/ptr.6229.CrossRefPubMed Papada E, Gioxari A, Amerikanou C, et al. Regulation of faecal biomarkers in inflammatory bowel disease patients treated with oral mastiha (Pistacia lentiscus) supplement: a double-blind and placebo-controlled randomised trial. Phytother Res PTR. 2019;33(2):360–9. https://​doi.​org/​10.​1002/​ptr.​6229.CrossRefPubMed
35.
go back to reference Triantafyllidi A, Xanthos T, Papalois A, Triantafillidis JK. Herbal and plant therapy in patients with inflammatory bowel disease. Ann Gastroenterol Q Publ Hell Soc Gastroenterol. 2015;28(2):210–20. Triantafyllidi A, Xanthos T, Papalois A, Triantafillidis JK. Herbal and plant therapy in patients with inflammatory bowel disease. Ann Gastroenterol Q Publ Hell Soc Gastroenterol. 2015;28(2):210–20.
38.
go back to reference Gupta I, Parihar A, Malhotra P, et al. Effects of Boswellia serrata gum resin in patients with ulcerative colitis. Eur J Med Res. 1997;2(1):37–43.PubMed Gupta I, Parihar A, Malhotra P, et al. Effects of Boswellia serrata gum resin in patients with ulcerative colitis. Eur J Med Res. 1997;2(1):37–43.PubMed
52.
go back to reference Giang J, Lan X, Crichton M, Marx W, Marshall S. Efficacy and safety of biophenol-rich nutraceuticals in adults with inflammatory gastrointestinal diseases or irritable bowel syndrome: a systematic literature review and meta-analysis. Nutr Diet J Dietit Assoc Aust. 2022;79(1):76–93. https://doi.org/10.1111/1747-0080.12672.CrossRef Giang J, Lan X, Crichton M, Marx W, Marshall S. Efficacy and safety of biophenol-rich nutraceuticals in adults with inflammatory gastrointestinal diseases or irritable bowel syndrome: a systematic literature review and meta-analysis. Nutr Diet J Dietit Assoc Aust. 2022;79(1):76–93. https://​doi.​org/​10.​1111/​1747-0080.​12672.CrossRef
Metadata
Title
Selected Use of Complementary and Alternative Medicine (CAM) Agents in IBD
Authors
Monica Dzwonkowski
Janak Bahirwani
Samantha Rollins
Alicia Muratore
Vikram Christian
Yecheskel Schneider
Publication date
01-12-2025
Publisher
Springer US
Published in
Current Gastroenterology Reports / Issue 1/2025
Print ISSN: 1522-8037
Electronic ISSN: 1534-312X
DOI
https://doi.org/10.1007/s11894-025-00960-0

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