Causal relationship between diabetes mellitus, glycemic traits and Parkinson’s disease: a multivariable mendelian randomization analysis
- Open Access
- 01-12-2024
- Idiopathic Parkinson Disease
- Research
Published in:
- Authors
- Qitong Wang
- Benchi Cai
- Lifan Zhong
- Jitrawadee Intirach
- Tao Chen
- Published in
- Diabetology & Metabolic Syndrome | Issue 1/2024
Abstract
Background
Observational studies have indicated an association between diabetes mellitus (DM), glycemic traits, and the occurrence of Parkinson’s disease (PD). However, the complex interactions between these factors and the presence of a causal relationship remain unclear. Therefore, we aim to systematically assess the causal relationship between diabetes, glycemic traits, and PD onset, risk, and progression.
Method
We used two-sample Mendelian randomization (MR) to investigate potential associations between diabetes, glycemic traits, and PD. We used summary statistics from genome-wide association studies (GWAS). In addition, we employed multivariable Mendelian randomization to evaluate the mediating effects of anti-diabetic medications on the relationship between diabetes, glycemic traits, and PD. To ensure the robustness of our findings, we performed a series of sensitivity analyses.
Results
In our univariable Mendelian randomization (MR) analysis, we found evidence of a causal relationship between genetic susceptibility to type 1 diabetes (T1DM) and a reduced risk of PD (OR = 0.9708; 95% CI: 0.9466, 0.9956; P = 0.0214). In our multivariable MR analysis, after considering the conditions of anti-diabetic drug use, this correlation disappeared with adjustment for potential mediators, including anti-diabetic medications, insulin use, and metformin use.
Conclusion
Our MR study confirms a potential protective causal relationship between genetically predicted type 1 diabetes and reduced risk of PD, which may be mediated by factors related to anti-diabetic medications.
Advertisement
- Title
- Causal relationship between diabetes mellitus, glycemic traits and Parkinson’s disease: a multivariable mendelian randomization analysis
- Authors
-
Qitong Wang
Benchi Cai
Lifan Zhong
Jitrawadee Intirach
Tao Chen
- Publication date
- 01-12-2024
- Publisher
- BioMed Central
- Published in
-
Diabetology & Metabolic Syndrome / Issue 1/2024
Electronic ISSN: 1758-5996 - DOI
- https://doi.org/10.1186/s13098-024-01299-8
This content is only visible if you are logged in and have the appropriate permissions.
This content is only visible if you are logged in and have the appropriate permissions.
