Hypoglycemia during hyperosmolar hyperglycemic crises is associated with long-term mortality
- Open Access
- 01-12-2024
- Hypoglycemia
- Research
Published in:
- Authors
- Tomás González-Vidal
- Carmen Lambert
- Ana Victoria García
- Elsa Villa-Fernández
- Pedro Pujante
- Jessica Ares-Blanco
- Edelmiro Menéndez Torre
- Elías Delgado-Álvarez
- Published in
- Diabetology & Metabolic Syndrome | Issue 1/2024
Abstract
Background
Previous research has indicated that hypoglycemia during hospitalization is a predictor of unfavorable outcomes in patients with diabetes. However, no studies have examined the long-term impact of hypoglycemia in adults admitted for hyperglycemic crises. The study was aimed to investigate the long-term implications of hypoglycemia during hyperosmolar hyperglycemic crises, particularly in terms of all-cause mortality.
Methods
This retrospective cohort study included 170 patients (82 men [48.2%], median age 72 years) admitted to a university hospital for hyperosmolar hyperglycemic crises, including pure hyperosmolar hyperglycemic states and hyperosmolar diabetic ketoacidoses. We separately investigated the prognostic significance of hypoglycemia on mortality during the initial intravenous insulin therapy phase and during the later subcutaneous insulin therapy phase, both during hospitalization and in the long term (median follow-up, 652 days; range 2–3460 days).
Results
Both hypoglycemia during the initial intravenous insulin therapy phase (observed in 26.5% of patients) and hypoglycemia during the later subcutaneous insulin therapy phase (observed in 52.7% of patients) were associated with long-term mortality. After adjusting for potential confounders, hypoglycemia during the initial intravenous insulin therapy phase remained associated with mortality (hazard ratio 2.10, 95% CI 1.27–3.46, p = 0.004).
Conclusions
Hypoglycemia during hyperosmolar hyperglycemic crises is a marker of long-term mortality, especially when it occurs during the initial intravenous insulin therapy phase.
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- Title
- Hypoglycemia during hyperosmolar hyperglycemic crises is associated with long-term mortality
- Authors
-
Tomás González-Vidal
Carmen Lambert
Ana Victoria García
Elsa Villa-Fernández
Pedro Pujante
Jessica Ares-Blanco
Edelmiro Menéndez Torre
Elías Delgado-Álvarez
- Publication date
- 01-12-2024
- Publisher
- BioMed Central
- Keywords
-
Hypoglycemia
Insulins
Insulins
Ketoacidosis - Published in
-
Diabetology & Metabolic Syndrome / Issue 1/2024
Electronic ISSN: 1758-5996 - DOI
- https://doi.org/10.1186/s13098-024-01329-5
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