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Cardiovascular Toxicology
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18-12-2024 | Hypertension | Research

Association Between Serum Essential Metal Elements and Blood Pressure in Children: A Cohort Study

Authors: Muhammad Fahad Tahir, Xiaofei Wu, Yuwei Wang, Qin Liu, Xizhou An, Daochao Huang, Lijing Chen, Lanling Chen, Xiaohua Liang

Published in: Cardiovascular Toxicology | Issue 1/2025

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Abstract

A limited number of cohort studies have explored the impact of serum essential metal elements on blood pressure (BP) or glycolipids and their regulatory mechanism in children. This study aimed to investigate the relationship between serum metal concentrations of iron (Fe), zinc (Zn), calcium (Ca), copper (Cu), and magnesium (Mg) and BP in children, and explore the potential mediating effects of glycolipid profiles. This cohort study included 1993 children (3566 BP measurements) aged 6–14 years in Chongqing, China. Serum essential metals, BP, lipid profiles, and glucose and insulin levels were measured. The relationship between serum metal levels and BP was analyzed using generalized linear and regression models, and a mediation analysis was performed to examine the potential mediating role of glycolipids. After adjusting for confounders, positive associations were found between serum Fe and Zn levels and BP parameters (all P < 0.05). A “U” style relationship between Cu and BP was found. Stronger associations were found in children aged ≤ 10 years, with sex-specific differences for Fe, Zn, and Cu. The relationship between elevated BP and serum Mg and Ca was not found. Our study found that triglycerides showed a significant relationship with Fe and Zn levels (P < 0.005). Moreover, triglycerides, partially mediate the effects of Zn on elevated BP. Serum Fe, Zn, and Cu concentrations were associated with BP in children, and age and sex differences were observed. Triglycerides may play a mediating role. These findings highlight the importance of maintaining an optimal serum essential metal status for cardiovascular health in children and suggest potential early prevention strategies.
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Metadata
Title
Association Between Serum Essential Metal Elements and Blood Pressure in Children: A Cohort Study
Authors
Muhammad Fahad Tahir
Xiaofei Wu
Yuwei Wang
Qin Liu
Xizhou An
Daochao Huang
Lijing Chen
Lanling Chen
Xiaohua Liang
Publication date
18-12-2024
Publisher
Springer US
Published in
Cardiovascular Toxicology / Issue 1/2025
Print ISSN: 1530-7905
Electronic ISSN: 1559-0259
DOI
https://doi.org/10.1007/s12012-024-09948-0

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