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17-06-2024 | Hyperemesis Gravidarum | RESEARCH

Hyperemesis gravidarum and the risk of offspring morbidity: a longitudinal cohort study

Authors: Nathalie Auger, Banmeet Padda, Philippe Bégin, Émilie Brousseau, Gabriel Côté-Corriveau

Published in: European Journal of Pediatrics

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Abstract

Purpose

Hyperemesis gravidarum has the potential to affect the long-term health of offspring. We examined whether maternal hyperemesis gravidarum was associated with the risk of hospitalization for childhood morbidity.

Methods

We conducted a longitudinal cohort study of 1,189,000 children born in Quebec, Canada, between April 2006 and March 2021. The main exposure measure was maternal hyperemesis gravidarum requiring hospitalization in the first or second trimester. The outcome was any pediatric admission between birth and 16 years of age, with follow-up ending in March 2022. We used Cox regression models adjusted for maternal and socioeconomic factors to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association between maternal hyperemesis gravidarum and childhood hospitalization.

Results

Among 1,189,000 children, 6904 (0.6%) were exposed to maternal hyperemesis gravidarum. Hospitalization rates at age 16 years were higher for children exposed to hyperemesis gravidarum than unexposed children (47.6 vs 43.9 per 100 children). Relative to no exposure, hyperemesis gravidarum was associated with a 1.21 times greater risk of any hospitalization before 16 years (95% CI 1.17–1.26). Hyperemesis gravidarum was associated with hospitalization for neurologic (HR 1.50, 95% CI 1.32–1.71), developmental (HR 1.51, 95% CI 1.29–1.76), digestive (HR 1.40, 95% CI 1.30–1.52), and allergic disorders (HR 1.39, 95% CI 1.24–1.56). When contrasted with preeclampsia, hyperemesis gravidarum was a stronger risk factor for these outcomes.
Conclusions: Maternal hyperemesis gravidarum is associated with an increased risk of childhood hospitalization, especially for neurologic, developmental, digestive, and atopic disorders.
What is Known:
Hyperemesis gravidarum is associated with neurodevelopmental disorders in offspring.
However, the effect of hyperemesis gravidarum on other childhood morbidity is unclear.
What is New:
In this longitudinal cohort study of 1.2 million children, maternal hyperemesis gravidarum was associated with a greater risk of hospitalization before age 16 years.
Exposure to hyperemesis gravidarum was associated with developmental, neurologic, atopic, and digestive morbidity in childhood.
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Literature
17.
go back to reference Pampalon R, Hamel D, Gamache P, Simpson A, Philibert MD (2014) Validation of a deprivation index for public health: a complex exercise illustrated by the Quebec index. Chronic Dis Inj Can 34:12–22CrossRefPubMed Pampalon R, Hamel D, Gamache P, Simpson A, Philibert MD (2014) Validation of a deprivation index for public health: a complex exercise illustrated by the Quebec index. Chronic Dis Inj Can 34:12–22CrossRefPubMed
Metadata
Title
Hyperemesis gravidarum and the risk of offspring morbidity: a longitudinal cohort study
Authors
Nathalie Auger
Banmeet Padda
Philippe Bégin
Émilie Brousseau
Gabriel Côté-Corriveau
Publication date
17-06-2024
Publisher
Springer Berlin Heidelberg
Published in
European Journal of Pediatrics
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI
https://doi.org/10.1007/s00431-024-05647-8