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Open Access 01-12-2023 | Hydrocephalus | Research

Effect of cerebrospinal fluid area mask correction on ¹²³I-FP-CIT SPECT images in idiopathic normal pressure hydrocephalus

Authors: Makoto Ohba, Ryota Kobayashi, Chifumi Iseki, Kazukuni Kirii, Daichi Morioka, Koichi Otani, Yasuyuki Ohta, Yukihiko Sonoda, Koji Suzuki, Masafumi Kanoto

Published in: BMC Medical Imaging | Issue 1/2023

Abstract

Background

Cerebrospinal fluid (CSF) area mask correction reduces the influence of low [¹²³I]-N-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl) nortropane (¹²³I-FP-CIT) accumulation in the volume of interest (VOI) by CSF area dilatation on the specific binding ratio (SBR) calculated using the Southampton method. We assessed the effect of CSF area mask correction on the SBR for idiopathic normal pressure hydrocephalus (iNPH) characterized by CSF area dilatation.

Methods

We enrolled 25 patients with iNPH who were assessed using ¹²³I-FP-CIT single-photon emission computed tomography (SPECT) before shunt surgery or the tap test. The SBRs with and without CSF area mask correction were calculated, and changes in quantitative values were verified. Additionally, the number of voxels in the striatal and background (BG) VOI before and after CSF area mask correction were extracted. The number of voxels after correction was subtracted from that before correction, and the volume removed by the CSF area mask correction was calculated. The volumes removed from each VOI were compared to verify their effect on SBR.

Results

The images of 20 and 5 patients with SBRs that were decreased and increased, respectively, by CSF area mask correction showed that the volumes removed from the BG region VOI were higher and lower, respectively than those in the striatal region.

Conclusions

The SBR before and after CSF area mask correction was associated with the ratio of the volume removed from the striatal and BG VOIs, and the SBR was high or low according to the ratio. The results suggest that CSF area mask correction is effective in patients with iNPH.

Trial registration

This study was registered in the UMIN Clinical Trials Registry (UMIN-CTR) as UMIN study ID: UMIN000044826. 11/07/2021.

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Title: Effect of cerebrospinal fluid area mask correction on 123I-FP-CIT SPECT images in idiopathic normal pressure hydrocephalus
Authors: Makoto Ohba
Ryota Kobayashi
Chifumi Iseki
Kazukuni Kirii
Daichi Morioka
Koichi Otani
Yasuyuki Ohta
Yukihiko Sonoda
Koji Suzuki
Masafumi Kanoto
Publication date: 01-12-2023
Publisher: BioMed Central
Keywords: Hydrocephalus
Hydrocephalus
Hydrocephalus
Published in: BMC Medical Imaging / Issue 1/2023
Electronic ISSN: 1471-2342
DOI: https://doi.org/10.1186/s12880-023-01038-x

Keynote webinar | Spotlight on modern management of frailty

Springer Medicine

Effect of cerebrospinal fluid area mask correction on ¹²³I-FP-CIT SPECT images in idiopathic normal pressure hydrocephalus

Abstract

Background

Methods

Results

Conclusions

Trial registration

Keynote webinar | Spotlight on modern management of frailty

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Trial registration

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