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Published in: AIDS and Behavior 2/2024

Open Access 29-12-2023 | Human Immunodeficiency Virus | Original Paper

Non-Adherence to Anti-Retroviral Therapy Among Adult People Living with HIV in Ethiopia: Systematic Review and Meta-Analysis

Authors: Tigabu Munye Aytenew, Solomon Demis, Binyam Minuye Birhane, Worku Necho Asferie, Amare Simegn, Gedefaye Nibret, Amare Kassaw, Sintayehu Asnakew, Yohannes Tesfahun, Henock Andualem, Berihun Bantie, Gebrie Kassaw, Demewoz Kefale, Shegaw Zeleke

Published in: AIDS and Behavior | Issue 2/2024

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Abstract

Human immunodeficiency virus remains a global public health problem. Despite efforts to determine the prevalence of non-adherence to ART and its predictors in Ethiopia, various primary studies presented inconsistent findings. Therefore, this review aimed to determine the pooled prevalence of non-adherence to ART and identify its predictors. We have searched PubMed, Google Scholar and Web of Science databases extensively for all available studies. A weighted inverse-variance random-effects model was used to compute the overall non-adherence to ART. The pooled prevalence of non-adherence to ART was 20.68% (95% CI: 17.74, 23.61); I2 = 98.40%; p < 0.001). Educational level of primary school and lower [AOR = 3.5, 95%CI: 1.7, 7.4], taking co-medications [AOR = 0.45, 95%CI: 0.35, 0.59], not using memory aids [AOR = 0.30, 95%CI: 0.13, 0.71], depression [AOR = 2.0, 95%CI: 1.05, 3.79], comorbidity [AOR = 2.12, 95%CI: 1.16, 3.09), under-nutrition [AOR = 2.02, 95%CI: 1.20, 3.43], not believing on ART can control HIV [AOR = 2.31, 95%CI: 1.92, 2.77], lack of access to health facilities [AOR = 3.86, 95%CI: 1.10, 13.51] and taking ART pills uncomfortably while others looking [AOR = 5.21, 95%CI: 2.56, 10.53] were significantly associated with non-adherence to anti-retroviral therapy. The overall pooled prevalence of non-adherence to ART was considerably high in Ethiopia. Educational status, taking co-medications, not using memory aids, depression, comorbidity, under nutrition, not believing on anti-retroviral therapy controls HIV, lack of access to health facilities and taking ART pills uncomfortably were independent predictors of non-adherence to ART in Ethiopia. Therefore, healthcare providers, adherence counselors and supporters should detect non-adherence behaviors and patients’ difficulties with ART early, and provide intensive counseling to promote adherence.
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Metadata
Title
Non-Adherence to Anti-Retroviral Therapy Among Adult People Living with HIV in Ethiopia: Systematic Review and Meta-Analysis
Authors
Tigabu Munye Aytenew
Solomon Demis
Binyam Minuye Birhane
Worku Necho Asferie
Amare Simegn
Gedefaye Nibret
Amare Kassaw
Sintayehu Asnakew
Yohannes Tesfahun
Henock Andualem
Berihun Bantie
Gebrie Kassaw
Demewoz Kefale
Shegaw Zeleke
Publication date
29-12-2023
Publisher
Springer US
Published in
AIDS and Behavior / Issue 2/2024
Print ISSN: 1090-7165
Electronic ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-023-04252-4

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