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Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 7/2023

21-01-2023 | Neurophthalmology

Hormone Replacement Therapy and the Incidence of Nonarteritic Anterior Ischemic Optic Neuropathy: a Nationwide Population-Based Study (2009–2018)

Authors: Chaeyeon Lee, Kyung-Do Han, Juhwan Yoo, Kyung-Ah Park, Sei Yeul Oh

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 7/2023

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Abstract

Purpose

This study aimed to assess the association between hormone replacement therapy (HRT) and the prevalence of nonarteritic anterior ischemic optic neuropathy (NAION) in menopausal women using national data from the entire Korean population.

Methods

The health screening data of 1,381,605 women between 40 and 90 years of age collected by the National Health Insurance Service (NHIS) of Korea between January 1, 2009, and December 31, 2018, were retrospectively reviewed. Before data analysis, the potential cofounders were adjusted for among all participants. Based on HRT use and its duration (classified into four groups), the hazard ratio (HR) and 95% confidence interval (CI) of NAION development were calculated via a Cox proportional hazards regression analysis using the nonuser group as a reference.

Results

Overall, 7824 NAION diagnoses were made during the mean follow-up of 8.22 years (standard deviation: 1.09 years) in 1,381,605 post-menopausal women. NAION was more common in the HRT group than in the non-HRT group (HR [95% CI]: 1.268 [1.197–1.344]). Furthermore, the risk of NAION increased along with increased HRT duration (p < 0.0001). In the multivariate analysis, the adjusted HRs of the < 2-year HRT group, the 2–5-year HRT group, and the ≥ 5-year HRT group were 1.19 (95% CI: 1.10–1.28), 1.3 (95% CI: 1.17–1.45), and 1.473 (95% CI: 1.31–1.65), respectively. Compared to women younger than 65 years, the HR of HRT for NAION was significantly higher than that of women older than 65 years (p < 0.0001).

Conclusion

Our population-based cohort study found that HRT was significantly associated with increased incidence of NAION. The incidence of NAION also increased with the duration of HRT.
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Metadata
Title
Hormone Replacement Therapy and the Incidence of Nonarteritic Anterior Ischemic Optic Neuropathy: a Nationwide Population-Based Study (2009–2018)
Authors
Chaeyeon Lee
Kyung-Do Han
Juhwan Yoo
Kyung-Ah Park
Sei Yeul Oh
Publication date
21-01-2023
Publisher
Springer Berlin Heidelberg
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 7/2023
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-023-05976-8

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