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25-04-2024 | Original Articles

Histological Changes of Porcine Animal Skin with Micro-focused Ultrasound

Authors: Meng Wang, Chong Zhang, Yi Li, Yan Yan

Published in: Aesthetic Plastic Surgery

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Abstract

Background

As a noninvasive alternative therapy, microfocused ultrasound (MFU) has become a research hotspot in recent years for its potential to enhance skin laxity. While several clinical studies have explored the effects of MFU on improving skin laxity, there is limited literature available on the histological changes resulting from MFU treatments. It has been established that the skin structure and composition of the Bama miniature pigs closely resembles that of humans, including collagen content, type I collagen distribution, and elastin distribution.

Methods

This study primarily focuses on examining the histological alterations in the skin tissue of Bama miniature pigs following MFU application. We also selected some typical clinical photographs of patients treated with MFU and compared the clinical effects with histological changes observed in porcine skin. The MFU device utilized in this study incorporates ultra-pulse technology and large focal area technology.

Results

Following the standard operating procedures provided by the manufacturer, different handles were used in different skin area of pigs. Biopsies were obtained immediately after treatment and 1 month after treatment. Significant histological changes were observed in the Bama miniature pigs skin, including collagen contraction and fragmentation, dilation and congestion of superficial dermal capillaries immediately after MFU treatment; dermal thickening, increased thickness and density of collagen fibers, elevated levels of elastin and type I collagen, as well as thickened fiber septa in the adipose layer 1 month later. These histological results corresponded to clinical findings in human, such as facial redness and swelling immediately after treatment, and improvement in facial relaxation after approximately 1 month after treatment.

Conclusion

Collectively, these histological findings provide valuable evidence supporting the clinical application of MFU for enhancing skin laxity.

No Level Assigned

This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.​springer.​com/​00266.
Literature
8.
go back to reference Liu Y, Chen J, Shang H, Liu C, Wang Y, Niu R, Wu J, Wei H (2010) Light microscopic, electron microscopic, and immunohistochemical comparison of bama minipig (Sus Scrofa domestica) and human skin. Comp Med 60(2):142–148PubMedPubMedCentral Liu Y, Chen J, Shang H, Liu C, Wang Y, Niu R, Wu J, Wei H (2010) Light microscopic, electron microscopic, and immunohistochemical comparison of bama minipig (Sus Scrofa domestica) and human skin. Comp Med 60(2):142–148PubMedPubMedCentral
Metadata
Title
Histological Changes of Porcine Animal Skin with Micro-focused Ultrasound
Authors
Meng Wang
Chong Zhang
Yi Li
Yan Yan
Publication date
25-04-2024
Publisher
Springer US
Published in
Aesthetic Plastic Surgery
Print ISSN: 0364-216X
Electronic ISSN: 1432-5241
DOI
https://doi.org/10.1007/s00266-024-04037-7