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Clinical and Translational Medicine
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Open Access 01-12-2017 | Review

Heterogeneity in retinoblastoma: a tale of molecules and models

Authors: Sonya Stenfelt, Maria K. E. Blixt, Charlotta All-Ericsson, Finn Hallböök, Henrik Boije

Published in: Clinical and Translational Medicine | Issue 1/2017

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Abstract

Retinoblastoma, an intraocular pediatric cancer, develops in the embryonic retina following biallelic loss of RB1. However, there is a wide range of genetic and epigenetic changes that can affect RB1 resulting in different clinical outcomes. In addition, other transformations, such as MYCN amplification, generate particularly aggressive tumors, which may or may not be RB1 independent. Recognizing the cellular characteristics required for tumor development, by identifying the elusive cell-of-origin for retinoblastoma, would help us understand the development of these tumors. In this review we summarize the heterogeneity reported in retinoblastoma on a molecular, cellular and tissue level. We also discuss the challenging heterogeneity in current retinoblastoma models and suggest future platforms that could contribute to improved understanding of tumor initiation, progression and metastasis in retinoblastoma, which may ultimately lead to more patient-specific treatments.
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Metadata
Title
Heterogeneity in retinoblastoma: a tale of molecules and models
Authors
Sonya Stenfelt
Maria K. E. Blixt
Charlotta All-Ericsson
Finn Hallböök
Henrik Boije
Publication date
01-12-2017
Publisher
Springer Berlin Heidelberg
Published in
Clinical and Translational Medicine / Issue 1/2017
Electronic ISSN: 2001-1326
DOI
https://doi.org/10.1186/s40169-017-0173-2

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