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04-05-2024 | Hepatocellular Carcinoma | Original Article

Current role and perspectives of living donor liver transplantation for hepatocellular carcinoma: systematic review of the past 20 years

Authors: Stefano Di Sandro, Leonardo Centonze, Barbara Catellani, Roberta Odorizzi, Daniela Caracciolo, Cristiano Guidetti, Paolo Magistri, Giuseppe Esposito, Gian Piero Guerrini, Fabrizio Di Benedetto

Published in: Updates in Surgery

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Abstract

Hepatocellular carcinoma (HCC) poses a significant global health challenge, and liver transplantation (LT) remains the best curative option. Living donor liver transplantation (LDLT) emerged as a potential solution to organ scarcity, reducing waitlist times. This comprehensive review explores LDLT practices, focusing on patient selection criteria and oncologic outcomes. A systematic review following PRISMA guidelines included 50 studies (2004–2023) with 8062 patients. Data encompassed baseline characteristics, HCC features, and oncologic outcomes. Further analysis categorized results by geography and publication year. Heterogeneity in patient demographics, tumor burden, and transplant characteristics was observed. Recent LDLT series demonstrated a shift towards refined selection criteria, increased neoadjuvant treatment, and improved oncologic outcomes. Geographic disparities revealed unique challenges in Eastern and Western practices. LDLT proves effective for HCC, addressing donor shortages. Evolving practices highlight the importance of refining inclusion criteria and optimizing tumor management. While geographic differences exist, LDLT, when judiciously applied, offers promising outcomes.
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Literature
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go back to reference Yoon Y-I, Song G-W, Lee S et al (2022) Salvage living donor liver transplantation versus repeat liver resection for patients with recurrent hepatocellular carcinoma and Child-Pugh class A liver cirrhosis: a propensity score-matched comparison. Am J Transplant 22:165–176. https://doi.org/10.1111/ajt.16790CrossRefPubMed Yoon Y-I, Song G-W, Lee S et al (2022) Salvage living donor liver transplantation versus repeat liver resection for patients with recurrent hepatocellular carcinoma and Child-Pugh class A liver cirrhosis: a propensity score-matched comparison. Am J Transplant 22:165–176. https://​doi.​org/​10.​1111/​ajt.​16790CrossRefPubMed
Metadata
Title
Current role and perspectives of living donor liver transplantation for hepatocellular carcinoma: systematic review of the past 20 years
Authors
Stefano Di Sandro
Leonardo Centonze
Barbara Catellani
Roberta Odorizzi
Daniela Caracciolo
Cristiano Guidetti
Paolo Magistri
Giuseppe Esposito
Gian Piero Guerrini
Fabrizio Di Benedetto
Publication date
04-05-2024
Publisher
Springer International Publishing
Published in
Updates in Surgery
Print ISSN: 2038-131X
Electronic ISSN: 2038-3312
DOI
https://doi.org/10.1007/s13304-024-01862-y
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