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Published in: Indian Journal of Thoracic and Cardiovascular Surgery 5/2022

21-03-2022 | Heparin | CORRESPONDENCE

Whether heparin causes hemolysis: an in silico and in vitro study

Authors: Surender, Sheemona Chowdhary, Deepak Kumar, Sumanpreet Kaur, Rajasri Bhattacharyya, Dibyajyoti Banerjee, Rupesh Kumar

Published in: Indian Journal of Thoracic and Cardiovascular Surgery | Issue 5/2022

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Excerpt

Heparin is the most commonly used anticoagulant for patients undergoing cardiothoracic surgery requiring cardiopulmonary bypass (CPB). Apart from the intravenous route and intracardiac route as cardioplegia fluid, it is also used to coat CPB circuits. Various components of the CPB circuit cause hemolysis at a different rate. Heparin-coated polyvinyl chloride (PVC) tubing causes more hemolysis, but it is considered by some authorities as sublethal [1]. To date, there is no focused investigation on heparin-induced hemolysis. Particularly the interaction of heparin with erythrocyte membrane protein is an unknown area. Therefore, in the instant work, we investigated heparin-induced hemolysis and studied the binding of heparin with erythrocyte membrane proteins. …
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Footnotes
1
Explained in supplementary section.
 
2
Explained in supplementary section.
 
3
Explained in supplementary section.
 
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Metadata
Title
Whether heparin causes hemolysis: an in silico and in vitro study
Authors
Surender
Sheemona Chowdhary
Deepak Kumar
Sumanpreet Kaur
Rajasri Bhattacharyya
Dibyajyoti Banerjee
Rupesh Kumar
Publication date
21-03-2022
Publisher
Springer Nature Singapore
Keyword
Heparin
Published in
Indian Journal of Thoracic and Cardiovascular Surgery / Issue 5/2022
Print ISSN: 0970-9134
Electronic ISSN: 0973-7723
DOI
https://doi.org/10.1007/s12055-022-01340-3

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