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Open Access 01-12-2024 | Heart Surgery | Case Report

Thrombotic Thrombocytopenia Purpura (TTP) following emergent aortic valve replacement after a complicated TAVR procedure: a case report and review of the literature

Authors: Xia Shao, Xiaobin Xu, Qingju Li, Ruying Hu, Kaiyu Tao, Weijun Yang, Aiqiang Dong

Published in: Journal of Cardiothoracic Surgery | Issue 1/2024

Abstract

Background

Thrombotic thrombocytopenic purpura (TTP) is a rare hematological disorder. The occurrence of TTP subsequent to an emergent aortic valve replacement after a TAVR procedure is exceedingly uncommon with only a few reported cases worldwide.

Case Presentation

We report the case of a 70-year-old female patient diagnosed with aortic insufficiency. Following a transcatheter aortic valve replacement, she underwent emergency aortic valve replacement under cardiopulmonary bypass on the subsequent day due to heart valve displacement. The postoperative diagnosis revealed TTP and symptomatic treatment involving plasma exchange was administered. After demonstrating steady improvement, the patient was eventually discharged.

Conclusion

Aortic valve replacement after TAVR is a high-risk procedure and increases susceptibility for developing secondary TTP. The diagnosis and treatment of secondary TPP is considerably challenging, and early diagnosis with symptomatic treatment including plasma exchange can increase patient survival.

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Title: Thrombotic Thrombocytopenia Purpura (TTP) following emergent aortic valve replacement after a complicated TAVR procedure: a case report and review of the literature
Authors: Xia Shao
Xiaobin Xu
Qingju Li
Ruying Hu
Kaiyu Tao
Weijun Yang
Aiqiang Dong
Publication date: 01-12-2024
Publisher: BioMed Central
Keywords: Heart Surgery
Aortic Valve Replacement
Thrombotic Thrombocytopenic Purpura
Aortic Valve Replacement
Aortic Valve Replacement
Thrombocytopenia
Hemolytic Anemia
Idiopathic Thrombocytopenic Purpura
Acute Kidney Injury
Published in: Journal of Cardiothoracic Surgery / Issue 1/2024
Electronic ISSN: 1749-8090
DOI: https://doi.org/10.1186/s13019-024-03055-5

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Thrombotic Thrombocytopenia Purpura (TTP) following emergent aortic valve replacement after a complicated TAVR procedure: a case report and review of the literature

Abstract

Background

Case Presentation

Conclusion

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