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Current Cardiology Reports

Unpacking Exosomes: A Therapeutic Frontier for Cardiac Repair

  • Open Access
  • 01-12-2025
  • Heart Failure
  • Regenerative Medicine (SM Wu, Section Editor)
Published in:
Authors
Elena McMullan
Darukeshwara Joladarashi
Raj Kishore
Published in
Current Cardiology Reports | Issue 1/2025

Abstract

Purpose of Review

The rising global prevalence of cardiovascular disease is driving the need for innovative biotherapeutics. Recently, exosomes-extracellular vesicles involved in paracrine signaling have shown promise in aiding heart repair associated with cardiovascular conditions. Their therapeutic potential encompasses several beneficial mechanisms, including anti-fibrosis, anti-inflammation, pro-angiogenesis, anti-oxidation, and anti-apoptosis, all contributing to improved cardiac function. This review provides a comprehensive overview of exosomes and highlights the latest research on their effectiveness in addressing current challenges in regenerative cardiac medicine.

Recent Findings

Current approaches revolve around elucidating and enhancing how different cell types, cargo, and delivery methods impact healing in a pathological cardiovascular environment.

Summary

The emerging field of therapeutic exosome research is promising for cardiac regeneration due to the beneficial effects of exosomal cargo. The expansion of mechanistic knowledge and the optimization of techniques are required before standard clinical application.
Title
Unpacking Exosomes: A Therapeutic Frontier for Cardiac Repair
Authors
Elena McMullan
Darukeshwara Joladarashi
Raj Kishore
Publication date
01-12-2025
Publisher
Springer US
Keyword
Heart Failure
Published in
Current Cardiology Reports / Issue 1/2025
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-025-02225-8
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This content is intended for healthcare professionals outside of the UK.

Independent Medical Education Grant:
  • Bayer HealthCare Pharmaceuticals Inc.
Learn more Link opens in a new window
Image Credits
Abstract graphic of layered, concentric circular shapes in bright green, pink, blue, and purple on a dark blue background. The rings and segments form a complex radial pattern without text/© Springer Health+ IME