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Open Access 01-12-2023 | Heart Failure | Research

Prevalence estimates of the insulin resistance and associated prevalence of heart failure among United Status adults

Authors: Xiaozhong Li, Jihong Wang, Liyan Niu, Ziqi Tan, Jianyong Ma, Ling He, Peng Yu, Xiao Liu, Juxiang Li

Published in: BMC Cardiovascular Disorders | Issue 1/2023

Abstract

Background

The triglyceride glucose (TyG) index, a metric for estimating insulin resistance (IR), is linked with cardiovascular disease (CVD) morbidity and mortality among the population regardless of diabetic status. However, IR prevalence and the association between the TyG index and heart failure (HF) in Americans is unclear.

Methods

The Nation Health and Nutrition Examination Survey (NHANES) (2009–2018) dataset was used. IR was defined by homeostatic model assessment of insulin resistance (HOMA-IR) > 2.0 and 1.5. The TyG index was calculated as Ln [fasting triglycerides (mg/dL) × fasting glucose (mg/dL)/2]. A weighted logistic regression was applied to evaluate the association between the TyG index and the prevalence of HF.

Results

This study comprised 12,388 people, including 322 (2.6%) individuals with HF. The average prevalence of IR was found to be 13.9% and 22.7% for cutoff values greater than 2.0 and 1.5, respectively. HOMA-IR and the TyG index showed a moderate correlation (r = 0.30). There is a significant positive association between the TyG index and HF prevalence (per 1-unit increment; adjusted OR [aOR]: 1.34; 95% confidence interval [CI]: 1.02–1.76). Patients with higher TyG values were associated with a prevalence of HF (OR:1.41; 95% CI: 1.01,1.95) (quartiles 4 vs 1–3). The TyG index is associated with a higher prevalence of dyslipidemia, coronary heart disease, and hypertension but not a stroke (cerebrovascular disease).

Conclusions

Our results show that IR does not considerably increase from 2008 to 2018 in American adults. A moderate correlation is noted between HOMA-IR and the TyG index. TyG index is associated with the prevalence of HF, as were other cardiovascular diseases.

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Title: Prevalence estimates of the insulin resistance and associated prevalence of heart failure among United Status adults
Authors: Xiaozhong Li
Jihong Wang
Liyan Niu
Ziqi Tan
Jianyong Ma
Ling He
Peng Yu
Xiao Liu
Juxiang Li
Publication date: 01-12-2023
Publisher: BioMed Central
Keywords: Heart Failure
Insulins
Insulins
Nutrition
Dyslipidemia
Published in: BMC Cardiovascular Disorders / Issue 1/2023
Electronic ISSN: 1471-2261
DOI: https://doi.org/10.1186/s12872-023-03294-9

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Prevalence estimates of the insulin resistance and associated prevalence of heart failure among United Status adults

Abstract

Background

Methods

Results

Conclusions

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Abstract

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Conclusions

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