Skip to main content

Advanced Search

Projected result for your current search:: 0

Search Operators:

You can use operators in your search query to narrow down your results even more. Click on the search operator to see an explanation of how it works.
Finds documents with exactly this word group, in exactly this word order and spelling (e.g. "employer branding").
Finds documents with both search terms (e.g. sales AND bonus).
Finds documents with one or the other search term (e.g. porsche OR volkswagen).
Finds documents with all search terms. Blank space is understood as AND (e.g. man robot production).
Finds documents with no appearance of the word behind NOT (e.g. ford NOT "harrison ford").
Finds documents where the search term is mentioned at least "n" times."n" may be any number (e.g. COUNT(gear)>8).
Finds documents with both search terms in any word order, permitting "n" words as a maximum distance between them. Best choose between 15 and 30 (e.g. NEAR(recruit, professionals, 20)).
Finds documents with the search term in word versions or composites. The asterisk * marks whether you wish them BEFORE, BEHIND, or BEFORE and BEHIND the search term (e.g. lightweight*, *lightweight, *lightweight*).
Finds documents with the search term in different spellings. "?" allows only one character (e.g. organi?ation).
Special characters are understood as AND (e.g. Miller Bros. & Sons).
 Log in
Top
Current Cardiology Reports

Precision Genetic Therapies: Balancing Risk and Benefit in Patients with Heart Failure

  • Open Access
  • 07-08-2024
  • Heart Failure
  • Heart Failure (HJ Eisen, Section Editor)
Published in:
Authors
Jamie R. Johnston
Eric D. Adler
Published in
Current Cardiology Reports | Issue 9/2024

Abstract

Purpose of Review

Precision genetic medicine is evolving at a rapid pace and bears significant implications for clinical cardiology. Herein, we discuss the latest advancements and emerging strategies in gene therapy for cardiomyopathy and heart failure.

Recent Findings

Elucidating the genetic architecture of heart failure has paved the way for precision therapies in cardiovascular medicine. Recent preclinical studies and early-phase clinical trials have demonstrated encouraging results that support the development of gene therapies for heart failure arising from a variety of etiologies. In addition to the discovery of new therapeutic targets, innovative delivery platforms are being leveraged to improve the safety and efficacy of cardiac gene therapies.

Summary

Precision genetic therapy represents a potentially safe and effective approach for improving outcomes in patients with heart failure. It holds promise for radically transforming the treatment paradigm for heart failure by directly targeting the underlying etiology. As this new generation of cardiovascular medicines progress to the clinic, it is especially important to carefully evaluate the benefits and risks for patients.
Title
Precision Genetic Therapies: Balancing Risk and Benefit in Patients with Heart Failure
Authors
Jamie R. Johnston
Eric D. Adler
Publication date
07-08-2024
Publisher
Springer US
Published in
Current Cardiology Reports / Issue 9/2024
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-024-02096-5
This content is only visible if you are logged in and have the appropriate permissions.

Other articles of this Issue 9/2024

The use of Intracardiac Echocardiography in Catheter Ablation of Atrial Fibrillation

  • Atrial Fibrillation
  • Invasive Electrophysiology and Pacing (EK Heist and S Nedios, Section Editors)

The Current State of Coronary Revascularization: Coronary Artery Bypass Graft Surgery Versus Percutaneous Coronary Interventions

  • CABG
  • Interventional Cardiology (SR Bailey and T Helmy, Section Editors)

Latest recommendations for endocarditis in adult congenital heart disease

Molecular Regulation of Cardiac Conduction System Development

  • Pacemaker
  • Regenerative Medicine (SM Wu, Section Editor)

Cardiac Sarcoidosis: Utilizing Cardiac MRI and PET-CT

  • Sarcoidosis
  • Cardiac PET, CT, and MRI (P Cremer, Section Editor)

A Comprehensive Review on the Electrocardiographic Manifestations of Cardiac Sarcoidosis: Patterns and Prognosis

  • Electrocardiography
  • Invasive Electrophysiology and Pacing (EK Heist and S Nedios, Section Editors)

Next-generation MRI contrast agents: preparing the field (Link opens in a new window)

New MRI contrast agents are reshaping diagnostic imaging, promising lower gadolinium exposure amid evolving practice guidelines. How can you optimise contrast selection, dosing, and patient care in this rapidly advancing field?

This content is intended for healthcare professionals outside of the UK.

Independent Medical Education Grant:
  • Bayer HealthCare Pharmaceuticals Inc.
Learn more Link opens in a new window
Image Credits
DNA editing illustration/© (M) vchalup / stock.adobe.com, Abstract graphic of layered, concentric circular shapes in bright green, pink, blue, and purple on a dark blue background. The rings and segments form a complex radial pattern without text/© Springer Health+ IME