Manual therapy remains an underutilized yet promising complementary intervention for headache management. Despite growing evidence supporting its efficacy, it is often overshadowed by pharmacological approaches and other non-pharmacological treatments such as acupuncture. This article highlights the potential role of manual therapy in reducing headache frequency and intensity, particularly in tension-type headaches and migraine. By addressing musculoskeletal dysfunctions and central sensitization, manual therapy can serve as a valuable component of multimodal care. Future research should focus on large-scale trials and cost-effectiveness analyses to strengthen the evidence base and promote its integration into clinical guidelines.