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Neurology Headache

Headache

Headache after stroke: what you need to know

Post-stroke headache is common yet underrecognized. Gain evidence-based insights on incidence and mechanisms, and practical guidance on acute and preventive therapies.

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Editor's Choice

Managing headache with noninvasive neuromodulation

Noninvasive neuromodulation devices have emerged as a safe option for migraine, trigeminal autonomic cephalgias, and other headache disorders, particularly for patients intolerant to or avoiding drug therapies.

Hallmarks of cluster headache

Explore the defining features of cluster headache – one of the most intense and debilitating pain conditions – including its clinical presentation, diagnostic challenges, pathophysiology, and evolving treatment strategies.

Vision loss linked to CGRP therapy

Discover a rare case of permanent visual impairment during a Behçet disease flare in a patient on CGRP therapy for migraine prevention. Do vasculitic conditions alter CGRP safety?

Diagnosing transient neurological dysfunction

Refine your approach to diagnosing brief, recurring neurological symptoms by identifying key features of common causes, such as TIAs, seizures, and migraine auras, and understanding the differential diagnosis for rarer paroxysmal disorders.

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Keynote webinar | Spotlight on functional neurological disorder

FND perplexes and frustrates patients and physicians alike. Limited knowledge and insufficient awareness delays diagnosis and treatment, and many patients feel misunderstood and stigmatized. How can you recognize FND and what are the treatment options?

Prof. Mark Edwards
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Video

Case Studies

Vision loss linked to CGRP therapy

Discover a rare case of permanent visual impairment during a Behçet disease flare in a patient on CGRP therapy for migraine prevention. Do vasculitic conditions alter CGRP safety?

STEMI masquerading as headache

Cardiac cephalalgia is a rare presentation of ACS, characterized by a migraine-like headache triggered by myocardial ischemia. This patient presented with severe headache and nausea. ECG confirmed inferior STEMI with first-degree AV block.

Can rimegepant alleviate airplane headache?

Despite its relatively low prevalence, the intense pain of airplane headache often leads to significant anxiety and fear of flying. This case indicates rimegepant is a promising therapeutic option.

Episode 21: Moving towards migraine freedom?

Newcomer PACAP could make the difference in migraine control

Anti-CGRP therapy has dramatically improved migraine treatment for many patients since its introduction in 2018. However, 30–40% of patients do not respond adequately to these drugs.

Prof. Messoud Ashina talks to us about PACAP and why targeting this pathway could offer a new future option for such patients.

Prof. Messoud Ashina
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Podcast

Current Reviews

Moderate to Severe Acute Migraine Attacks: An Opinion Paper on the Use of Triptans and Triptan-NSAIDs Combinations in Individualized Treatment Plans

This opinion paper on the acute treatment of migraine addresses the definition and recognition of acute migraine attacks, highlighting the variety of symptoms and manifestations. It describes the available treatments and guidelines, noting …

Neuro-ophthalmology and migraine: visual aura and its neural basis

  • Open Access
  • Aura
  • Review

Migraine is a chronic and complex neurological disorder commonly characterized by an intense, unilateral cephalgia often described as throbbing or pulsating, typically lasting between 4 and 72 h. However, headache characteristics can vary widely …

Episodic Migraine in the Pediatric Population: Behavioral Therapies and other Non-Pharmacological Treatment Options

  • Open Access
  • Migraine
  • Episodic Migraine (S Parikh, Section Editor)

Headaches rank among the top five health issues in children [ 1 ], affecting up to 58.4% of children and adolescents at some point [ 2 ]. Their prevalence has been rising globally [ 3 ], significantly impacting quality of life, social interactions …

Nervus Intermedius Neuralgia

Nervus intermedius neuralgia (NIN), previously known as geniculate neuralgia or Hunt’s neuralgia, is a diagnosis in the International Classification of Headache Disorders, 3rd edition (ICHD-3), categorized in Chap. 13 as painful lesions of the …

Keynote webinar | Spotlight on sleep in brain health

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.

Dr. Rolf Fronczek
Dr. Renata Riha
Dr. Sven Rupprecht
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Video

Further Reading

Association between serum high-sensitivity C-reactive protein levels and migraine: a REFORM study

The precise neurobiologic mechanisms underlying migraine remain elusive, yet they are believed to involve pro-inflammatory mediators [ 1 , 2 ]. These mediators, including specific cytokines, chemokines, prostaglandins, and neuropeptides, promote …

Sex and gender-related differences in neurological diseases: current challenges and recommendations for clinical practice

Neurological diseases include a large variety of conditions ranging from inflammatory, vascular and neurodegenerative disorders to epilepsy and headache. The impact of sex and gender on various aspects of these conditions (epidemiology, risk …

A proof-of-concept study on the effectiveness of botulinum toxin on spasticity plus syndrome in multiple sclerosis

The concept of spasticity-plus syndrome (SPS) was introduced in 2020 as a cluster of multiple sclerosis (MS) symptoms, including spasticity, spasms/cramps, pain, bladder dysfunction, sleep disorders, fatigue and tremor [ 1 , 2 ]. Unlike traditional …

Moderate to Severe Acute Migraine Attacks: An Opinion Paper on the Use of Triptans and Triptan-NSAIDs Combinations in Individualized Treatment Plans

This opinion paper on the acute treatment of migraine addresses the definition and recognition of acute migraine attacks, highlighting the variety of symptoms and manifestations. It describes the available treatments and guidelines, noting …

Related topics

Managing headache with noninvasive neuromodulation

Noninvasive neuromodulation devices have emerged as a safe option for migraine, trigeminal autonomic cephalgias, and other headache disorders, particularly for patients intolerant to or avoiding drug therapies.

Read more
Image Credits
Woman holding head/© Tero Vesalainen / Getty Images / iStock (symbolic image with model), Neuromodulation concept/© ArtemisDiana / Getty Images, Cluster headache concept/© Prostock-studio / Stock.adobe.com (symbolic image with model), Woman speaking to doctor/© Seventyfour / stock.adobe.com (symbolic image with models), Neurologist examining MRI brain scan/© Gorodenkoff / stock.adobe.com (symbolic image with model), Human brain illustration/© (M) CHRISTOPH BURGSTEDT / SCIENCE PHOTO LIBRARY / Getty Images, Woman with migraine in a crowd/© epic_images / stock.adobe.com (symbolic image with model), Man with headache/© Peter Carruthers / Getty Images / iStock (symbolic image with model), Woman on plane with eyes closed/© skynesher / Getty Images / iStock (symbolic image with model), Medicine Matters Podcast promo image/© Springer Medizin GmbH, Hand holding illustration of brain on scenic background/© Natali_Mis / Getty Images / iStock, Boy with headache lying on a bed/© Pollyana Ventura / Getty Images / iStock (symbolic image with model), Woman speaking to doctor about headache/© terovesalainen / stock.adobe.com (symbolic image with models)