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Neoadjuvant immunotherapy in squamous cell carcinoma of the head and neck: current evidence and future perspectives

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Abstract

Head and Neck Squamous Cell Carcinoma (HNSCC) is a highly aggressive malignant tumor. Traditional therapeutic approaches have limited efficacy in locally advanced HNSCC patients, and neoadjuvant immunotherapy has emerged as a new hope. However, the current outcomes of neoadjuvant immunotherapy for HNSCC are not yet optimal and urgently need improvement. This article comprehensively reviews the clinical research progress of neoadjuvant immunotherapy in the field of HNSCC treatment. By integrating perspectives from the regulatory mechanisms of the immune microenvironment, we propose future research directions for enhancing the efficacy of neoadjuvant immunotherapy for HNSCC patients.
Title
Neoadjuvant immunotherapy in squamous cell carcinoma of the head and neck: current evidence and future perspectives
Authors
Bocheng Zhang
Haolei Tan
Jingyu Kuang
Bo Zhou
Shixuan Liang
Xiao Pang
Yu Ouyang
Zhang Zhang
Ying Long
Hailin Zhang
Publication date
10-11-2025
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2025
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/s12943-025-02487-4
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