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Neurological Sciences

Only anti-GM4 antibody positivity in a Chinese girl with overlapping MFS/GBS: a case report

Published in:
Authors
Jing Chen
Maoqiang Tian
XiaoMei Shu
Published in
Neurological Sciences | Issue 5/2024

Abstract

Background

Guillain-Barré syndrome (GBS), as the most common cause of acute flaccid paralysis worldwide, is considered a part of a clinical spectrum in which discrete, complete, or incomplete forms of GBS and overlapping syndromes lie on the basis of their clinical features. The term overlapping Miller Fisher syndrome (MFS)/GBS is used when patients with MFS also suffer from progressive motor weakness of the limbs. Anti-ganglioside GQ1b has been specifically associated with MFS and ophthalmoplegia.

Case description

Here, we report a Chinese girl who was diagnosed with overlapping MFS/GBS showing acute flaccid paralysis of all four limbs, sensory symptoms, cranial nerve dysfunction, autonomic involvement, ophthalmoplegia, and ataxia. She had high serum and cerebrospinal fluid titres of monospecific anti-GM4 IgG antibody instead of anti-GQ1b antibody in the acute phase.

Conclusion

Anti-GM4 antibodies usually coexist with other antiganglioside antibodies, leading to missed diagnoses. The findings of the present study show that antibodies to ganglioside GM4 may in overlapping MFS/GBS as the lone immunological factors.
Title
Only anti-GM4 antibody positivity in a Chinese girl with overlapping MFS/GBS: a case report
Authors
Jing Chen
Maoqiang Tian
XiaoMei Shu
Publication date
25-01-2024
Publisher
Springer International Publishing
Published in
Neurological Sciences / Issue 5/2024
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-024-07300-6
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