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Gout and psoriatic disease: an evolving conundrum

The overlap between gout and psoriatic disease has been known since the 1980s. But what are the key mechanisms underlying this association, how does it influence management, and should "Psout" be considered a novel disease?

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Editor's Choice

Thyroid dysfunction in inflammatory rheumatic diseases

Thyroid disease is a common comorbidity in inflammatory rheumatic diseases and complicates disease management and treatment. Integrated strategies are crucial for optimizing outcomes.

Gouty lumbar spinal stenosis

  • Open Access
  • Gout
  • Case Study

An unusual case of lumbar spinal stenosis caused by gouty tophi in a 26-year-old man. Physicians should be alert to the possibility of spinal gout in patients who present with back pain.

Colchicine prophylaxis reduces CV events in patients with gout

  • 09-01-2025
  • Gout
  • News

Taking colchicine prophylaxis at the time of initiating urate-lowering therapy for gout flare could reduce the risk for cardiovascular events.

Urate lowering to target feasible in patients with gout and CKD

Urate-lowering therapy to below 6 mg/dL in people with gout and chronic kidney disease does not increase the risks for kidney disease progressing to severe or end-stage.

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Case Studies

Gouty lumbar spinal stenosis

  • Open Access
  • Gout
  • Case Study

An unusual case of lumbar spinal stenosis caused by gouty tophi in a 26-year-old man. Physicians should be alert to the possibility of spinal gout in patients who present with back pain.

Current Reviews

Gout, Hyperuricemia, and the Intestinal Microbiome

  • Open Access
  • Gout
  • Review

Gout is a disease of hyperuricemia (HU) leading to monosodium urate crystal deposition in the joint, resulting in inflammation and joint damage. Recently, efforts have been made to characterize the intestinal microbiome of patients who suffer from …

Effects of sodium-glucose cotransporter-2 inhibitors on serum urate levels and gout in patients with and without type 2 diabetes: a systematic review and network meta-analysis

Type 2 diabetes is commonly associated with elevated uric acid levels, which increase the risk of cardiovascular and renal complications and impair quality of life. SGLT-2 inhibitors lower blood glucose levels independently of insulin and may also …

Integrating natural products with modern medicine in the treatment of gouty arthritis: a review

  • Open Access
  • Gout
  • Review

Gout is an inflammatory form of arthritis caused by hyperuricemia, a condition in which uric acid levels in the body become excessively high. When this occurs, monosodium urate (MSU) crystals can accumulate in the joints, triggering intense pain …

Endoscopic management of lumbar spinal tophaceous gout: six cases treated with percutaneous transforaminal (PTED) and interlaminar (PIED) discectomy and a literature review

Gout is a metabolic disease characterized by the deposition of monosodium urate (MSU) crystals in various joints throughout the body, triggering local inflammatory responses and tissue destruction. Gout typically affects the peripheral joints …

Further Reading

Gout, Hyperuricemia, and the Intestinal Microbiome

  • Open Access
  • Gout
  • Review

Gout is a disease of hyperuricemia (HU) leading to monosodium urate crystal deposition in the joint, resulting in inflammation and joint damage. Recently, efforts have been made to characterize the intestinal microbiome of patients who suffer from …

Costal cartilage mimics urate on DECT

  • Open Access
  • Gout
  • Scientific Article

Dual-energy CT (DECT) is widely used in both the clinical management of gout and in research, based on the ability of the technique to identify (and quantify) deposits of monosodium urate crystals (MSU). That identification revolves around the …

Ultrasound as a useful imaging modality to aid diagnosis and monitoring of pegloticase treatment response in patients with uncontrolled gout: a preliminary study

  • Open Access
  • Gout
  • Original Research Article

Gout is a chronic inflammatory disease characterized by elevated serum urate (SU) levels, subsequent monosodium urate (MSU) crystal deposits, tophi, and gout flares [ 1 , 2 ]. SU remains above 6.0 mg/dL in patients who either have oral …

Lansoprazole associated with a relatively lower gout risk among PPI users: a nationwide retrospective study

Proton pump inhibitors (PPIs) are one of the most frequently prescribed drug classes, with approximately one-quarter of adults using them globally [ 1 ]. The most common indications for PPIs were gastroprotection for gastrointestinal irritant …