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European Archives of Psychiatry and Clinical Neuroscience

16-05-2024 | Original Paper

Glutamate imbalance in key structure of the default mode network in adults with attention-deficit/hyperactivity disorder

Authors: Marcos Vinícius Vidor, Eduardo Schneider Vitola, Cibele Edom Bandeira, Alexandre Ribeiro Martins, Maria Eduarda de Araujo Tavares, Renata Basso Cupertino, Alana Castro Panzenhagen, Bruna Santos da Silva, Isabel Ghirardi Falkenberg, Pedro Olavo Barreto, Stefania Pigatto Teche, Felipe Almeida Picon, Luis Augusto Rohde, Diego L. Rovaris, Claiton Henrique Dotto Bau, Eugenio Horacio Grevet

Published in: European Archives of Psychiatry and Clinical Neuroscience

Abstract

The default mode network (DMN) is atypically active in patients with ADHD, likely contributing to the inattention patterns observed in patients with the disorder. Nonetheless, magnetic resonance spectroscopy (MRS) studies have rarely targeted the posterior cingulate cortex, a key DMN region, and little is known about the biochemical setting within this network in patients with ADHD. We aimed to assess the differences in metabolite profiles of the posterior cingulate cortex—a key region of the DMN—between patients with ADHD and controls. Five brain metabolites—glutamate, inositol, N-acetyl aspartate, choline, and creatine—were measured through MRS in the posterior cingulate cortex of patients and controls in a 3.0 T scanner. Between-group comparison of neurometabolite concentrations in PCC was performed using multivariate analysis of covariance. A total of 88 patients and 44 controls were included in the analysis. Patients with ADHD showed lower levels of glutamate in the posterior cingulate cortex compared to controls (p = 0.003). Lower concentrations of glutamate in the posterior cingulate cortex suggest that a glutamatergic imbalance within the posterior cingulate cortex might play a role in the pathogenesis of ADHD. Further understanding of the causes and consequences of such glutamate decrease might help explain how some glutamate-related drug effects impact on ADHD symptomatology.

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Title: Glutamate imbalance in key structure of the default mode network in adults with attention-deficit/hyperactivity disorder
Authors: Marcos Vinícius Vidor
Eduardo Schneider Vitola
Cibele Edom Bandeira
Alexandre Ribeiro Martins
Maria Eduarda de Araujo Tavares
Renata Basso Cupertino
Alana Castro Panzenhagen
Bruna Santos da Silva
Isabel Ghirardi Falkenberg
Pedro Olavo Barreto
Stefania Pigatto Teche
Felipe Almeida Picon
Luis Augusto Rohde
Diego L. Rovaris
Claiton Henrique Dotto Bau
Eugenio Horacio Grevet
Publication date: 16-05-2024
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Psychiatry and Clinical Neuroscience
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-024-01805-z

EASD 2024

Springer Medicine

Glutamate imbalance in key structure of the default mode network in adults with attention-deficit/hyperactivity disorder

Abstract

EASD 2024

Springer Medicine

Abstract

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