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Published in: Current Oncology Reports 3/2023

21-01-2023 | Glucocorticoid | CANCER REHABILITATION (M CLARK, SECTION EDITOR)

Graft-Versus-Host Disease: an Update on Functional Implications and Rehabilitation Interventions

Authors: Lauren Brothers, Jasmine Malhotra, Cody Andrews, Sean R. Smith

Published in: Current Oncology Reports | Issue 3/2023

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Abstract

Purpose of Review

Despite advances in treatment, chronic graft-versus-host disease (cGVHD) remains a highly morbid complication of allogeneic hematopoietic stem cell transplantation. Due to direct effects of the disease on specific body sites, and its treatment, patients lose function. This review summarizes the latest evidence surrounding how cGVHD affects function, and restorative interventions.

Recent Findings

Different body sites of cGVHD carry a higher risk of functional decline, including pulmonary and sclerotic/fascial. Support should be comprehensive and individualized, with precautions taken to avoid worsening fibrosis, offloading painful joints and fractures, and utilizing function-directed skilled therapies. Inpatient rehabilitation improves function in hospitalized people with cGVHD.

Summary

For people with cGVHD, rehabilitation addresses different aspects of impaired function across the spectrum of disease. Given the dynamic nature of the disease process, routine assessment may be warranted. Rehabilitation may also improve deleterious effects of anti-cGVHD medication including glucocorticoids and tyrosine kinase inhibitors.
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Metadata
Title
Graft-Versus-Host Disease: an Update on Functional Implications and Rehabilitation Interventions
Authors
Lauren Brothers
Jasmine Malhotra
Cody Andrews
Sean R. Smith
Publication date
21-01-2023
Publisher
Springer US
Published in
Current Oncology Reports / Issue 3/2023
Print ISSN: 1523-3790
Electronic ISSN: 1534-6269
DOI
https://doi.org/10.1007/s11912-023-01363-y

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