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03-01-2024 | Glomerulonephritis | Review article

Angiotensin II and post-streptococcal glomerulonephritis

Authors: Jesus A. Mosquera-Sulbaran, Adriana Pedreañez, Yenddy Carrero, Juan Pablo Hernandez-Fonseca

Published in: Clinical and Experimental Nephrology | Issue 5/2024

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Abstract

Background

Post-streptococcal glomerulonephritis (PSGN) is a consequence of the infection by group A beta-hemolytic streptococcus. During this infection, various immunological processes generated by streptococcal antigens are triggered, such as the induction of antibodies and immune complexes. This activation of the immune system involves both innate and acquired immunity. The immunological events that occur at the renal level lead to kidney damage with chronic renal failure as well as resolution of the pathological process (in most cases).

Summary

Angiotensin II (Ang II) is a molecule with vasopressor and pro-inflammatory capacities, being an important factor in various inflammatory processes. During PSGN some events are defined that make Ang II conceivable as a molecule involved in the inflammatory processes during the disease.

Conclusion

This review is focused on defining which reported events would be related to the presence of this hormone in PSGN.
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Metadata
Title
Angiotensin II and post-streptococcal glomerulonephritis
Authors
Jesus A. Mosquera-Sulbaran
Adriana Pedreañez
Yenddy Carrero
Juan Pablo Hernandez-Fonseca
Publication date
03-01-2024
Publisher
Springer Nature Singapore
Published in
Clinical and Experimental Nephrology / Issue 5/2024
Print ISSN: 1342-1751
Electronic ISSN: 1437-7799
DOI
https://doi.org/10.1007/s10157-023-02446-7

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