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Current Cardiology Reports

Global Burden of Cardiovascular Disease: What Should Be Expected in the Next 25 Years?

  • 01-12-2026
  • Review
Published in:
Authors
Unaiza Naeem
Salil Deo
Amirhossein Sahebkar
Sana Sheikh
Adeel Khoja
Elizabeth M. Vaughan
Ali bin Abdul Jabbar
Dinesh K. Kalra
Leandro Slipczuk
Salim Shahbuddin Virani
Published in
Current Cardiology Reports | Issue 1/2026

Abstract

Purpose of Review

The aim of this review is to evaluate the evolving burden of cardiovascular disease (CVD) between 2025 and 2050.

Recent Findings

Between 1990–2023, CVD deaths increased from 13.1 million to 19.2 million, with prevalence rising from 311 to 626 million cases. Most CVD burden is attributable to modifiable risk factors, led by high systolic blood pressure (SBP).

Summary

By 2050, CVD mortality will reach 35.6 million deaths annually, while prevalence will be at 1.14 billion cases globally. Metabolic, environmental and behavioral determinants will be key drivers, varying across regions according to sociodemographic index. Age-standardized mortality rates will decline, but absolute numbers of people living with CVD will rise due to population growth, aging, and possibly also improved access to care, especially in low-middle income countries. Prevention strategies, early detection and treatment, and better implementation of what is already known are necessary to address this burden.
Title
Global Burden of Cardiovascular Disease: What Should Be Expected in the Next 25 Years?
Authors
Unaiza Naeem
Salil Deo
Amirhossein Sahebkar
Sana Sheikh
Adeel Khoja
Elizabeth M. Vaughan
Ali bin Abdul Jabbar
Dinesh K. Kalra
Leandro Slipczuk
Salim Shahbuddin Virani
Publication date
01-12-2026
Publisher
Springer US
Published in
Current Cardiology Reports / Issue 1/2026
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-026-02355-7
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This content is intended for healthcare professionals outside of the UK.

Independent Medical Education Grant:
  • Bayer HealthCare Pharmaceuticals Inc.
Learn more Link opens in a new window
Image Credits
Abstract graphic of layered, concentric circular shapes in bright green, pink, blue, and purple on a dark blue background. The rings and segments form a complex radial pattern without text/© Springer Health+ IME