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03-09-2024 | Glioma | Review

The effect of depression and anxiety on survival in patients with glioma: a systematic review and meta-analysis

Authors: Jiahan Dong, Qiannan Chen, Shimeng Weng, Lingyu Liu, Jiangwei Wang, Shengyu Fang, Xing Fan, Tao Jiang

Abstract

Purpose

Depression and anxiety’s impact on glioma patient survival lacks consensus. Understanding these effects can highlight the importance of identifying depression and anxiety in glioma patients, and inform future treatments. This systematic review and meta-analysis aims to clarify the impact of depression and anxiety on glioma patient survival.

Methods

We conducted a systematic literature search of major databases, including PubMed, Embase, Web of Science Core Collection, Cochrane Library, and PsycINFO, from inception to June 2023, to identify relevant studies. Eligible studies were those that examined the association between depression, anxiety, or both, and survival outcomes in glioma patients. Data were extracted and analyzed using fixed-effects meta-analysis models to calculate pooled hazard ratios (HRs) and 95% confidence intervals (CIs).

Results

A total of 15 studies met the inclusion criteria, encompassing a diverse range of glioma patients across different clinical settings and stages. The meta-analysis revealed a statistically significant association between depression and reduced overall survival in glioma patients, with a pooled HR of 1.65 (95% CI: 1.41–1.83, 11 studies). The preliminary univariate meta-regression results indicate no impact of individual study characteristics on the effect size. Likewise, anxiety was associated with worse overall survival, with a pooled HR of 1.65 (95% CI: 1.18–2.31, 5 studies).

Conclusions

This meta-analysis underscores the vital need to identify and treat depression and anxiety in glioma patients. Future research should explore the underlying mechanisms, aiding the creation of interventions enhancing both mental health and clinical outcomes for this vulnerable group.

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Title: The effect of depression and anxiety on survival in patients with glioma: a systematic review and meta-analysis
Authors: Jiahan Dong
Qiannan Chen
Shimeng Weng
Lingyu Liu
Jiangwei Wang
Shengyu Fang
Xing Fan
Tao Jiang
Publication date: 03-09-2024
Publisher: Springer US
Keywords: Glioma
Glioma
Glioma
Anxiety
Glioblastoma
Glioblastoma
Glioblastoma
Published in: Journal of Neuro-Oncology
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-024-04799-9

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The effect of depression and anxiety on survival in patients with glioma: a systematic review and meta-analysis

Abstract

Purpose

Methods

Results

Conclusions

Advances in Alzheimer's

EASD 2024

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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Advances in Alzheimer's