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Drugs

Dordaviprone: First Approval

  • 25-10-2025
  • Glioma
  • AdisInsight Report
Published in:
Author
Hannah A. Blair
Published in
Drugs | Issue 1/2026

Abstract

Dordaviprone (MODEYSO™) is a protease activator being developed by Chimerix for the treatment of various cancers, including glioma, glioblastoma, endometrial cancer, ovarian cancer, acute myeloid leukaemia, acute lymphoblastic leukaemia, myelodysplastic syndrome and colorectal cancer. On 6 August 2025, dordaviprone received accelerated approval in the USA for the treatment of adult and paediatric patients 1 year of age and older with diffuse midline glioma harbouring an H3 K27M mutation with progressive disease following prior therapy. This article summarizes the milestones in the development of dordaviprone leading to this first approval for glioma.
Title
Dordaviprone: First Approval
Author
Hannah A. Blair
Publication date
25-10-2025
Publisher
Springer International Publishing
Published in
Drugs / Issue 1/2026
Print ISSN: 0012-6667
Electronic ISSN: 1179-1950
DOI
https://doi.org/10.1007/s40265-025-02252-3
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Keynote webinar | Spotlight on dry eye disease

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  • Webinar | 28-05-2026 | 13:00 (CEST)

DED is highly prevalent yet challenging to diagnose and treat. Join leading experts to explore the latest developments and gain practical guidance on effective management in busy clinical settings. Brought to you by Springer Medicine and Eye.

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