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15-08-2024 | Glioma in Children | Review

Advances in the Treatment of Pediatric Low-Grade Gliomas

Authors: Inci Yaman Bajin, Eric Bouffet

Published in: Current Neurology and Neuroscience Reports | Issue 10/2024

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Abstract

Purpose of Review

Pediatric low-grade gliomas (pLGGs) often result in significant long-term morbidities despite high overall survival rates. This review aims to consolidate the current understanding of pLGG biology and molecular features and provide an overview of current and emerging treatment strategies.

Recent Findings

Surgical resection remains a primary treatment modality, supplemented by chemotherapy and radiotherapy in specific cases. However, recent advances have elucidated the molecular underpinnings of pLGGs, revealing key genetic abnormalities such as BRAF fusions and mutations and the involvement of the RAS/MAPK and mTOR pathways. Novel targeted therapies, including MEK, BRAF and pan-RAF inhibitors, have shown promise in clinical trials, demonstrating significant efficacy and manageable toxicity.

Summary

Understanding of pLGGs has significantly improved, leading to more personalized treatment approaches. Targeted therapies have emerged as effective alternatives, potentially reducing long-term toxicities. Future research should focus on optimizing therapy sequences, understanding long-term impacts, and ensuring global accessibility to advanced treatments.
Literature
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Metadata
Title
Advances in the Treatment of Pediatric Low-Grade Gliomas
Authors
Inci Yaman Bajin
Eric Bouffet
Publication date
15-08-2024

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