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01-11-2024 | Glioblastoma | Review Article

DDX3X dynamics, glioblastoma's genetic landscape, therapeutic advances, and autophagic interplay

Authors: Arpit Sharma, Shruti S. Raut, Alok Shukla, Shivani Gupta, Amit Singh, Abha Mishra

Published in: Medical Oncology | Issue 11/2024

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Abstract

Glioblastoma is one of the most aggressive and deadly forms of cancer, posing significant challenges for the medical community. This review focuses on key aspects of Glioblastoma, including its genetic differences between primary and secondary types. Temozolomide is a major first-line treatment for Glioblastoma, and this article explores its development, how it works, and the issue of resistance that limits its effectiveness, prompting the need for new treatment strategies. Gene expression profiling has greatly advanced cancer research by revealing the molecular mechanisms of tumors, which is essential for creating targeted therapies for Glioblastoma. One important protein in this context is DDX3X, which plays various roles in cancer, sometimes promoting it or otherwise suppressing it. Additionally, autophagy, a process that maintains cellular balance, has complex implications in cancer treatment. Understanding autophagy helps to identify resistance mechanisms and potential treatments, with Chloroquine showing promise in treating Glioblastoma. This review covers the interplay between Glioblastoma, DDX3X, and autophagy, highlighting the challenges and potential strategies in treating this severe disease.
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Metadata
Title
DDX3X dynamics, glioblastoma's genetic landscape, therapeutic advances, and autophagic interplay
Authors
Arpit Sharma
Shruti S. Raut
Alok Shukla
Shivani Gupta
Amit Singh
Abha Mishra
Publication date
01-11-2024
Publisher
Springer US
Published in
Medical Oncology / Issue 11/2024
Print ISSN: 1357-0560
Electronic ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-024-02525-z

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