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Update of the 2021 WHO classification of tumors of the central nervous system: adult diffuse gliomas

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Excerpt

The fifth edition of the WHO classification of tumors of the central nervous system (CNS) [17], published in 2021, has become more reliant on molecular testing for the diagnosis and grading of diffuse gliomas, compared to the 2016 WHO revised 4th edition [6, 9] that adopted molecular information to define tumor entities for the first time. Under the 2021 revision, only three primary tumor types remained in the group of diffuse gliomas in adults (termed “adult-type diffuse gliomas”), namely, “astrocytoma, IDH-mutant,” “oligodendroglioma, IDH-mutant and 1p/19q codeleted,” and “glioblastoma, IDH-wildtype,” all of which are solely defined by canonical molecular alterations regardless of morphological features. …
Title
Update of the 2021 WHO classification of tumors of the central nervous system: adult diffuse gliomas
Author
Takashi Komori
Publication date
20-12-2022
Publisher
Springer Nature Singapore
Published in
Brain Tumor Pathology / Issue 1/2023
Print ISSN: 1433-7398
Electronic ISSN: 1861-387X
DOI
https://doi.org/10.1007/s10014-022-00446-1
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