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Current Nutrition Reports

Ketogenic Diet for Malignant Gliomas: a Review

  • 01-09-2020
  • Glioblastoma
  • Nutrition and the Brain (J Nasser, Section Editor)
Published in:
Authors
Jonathan G. Thomas
Erol Veznedaroglu
Published in
Current Nutrition Reports | Issue 3/2020

Abstract

Purpose of Review

In this review, we examine the postulated mechanisms of therapeutic effect of ketogenic diets in the treatment of gliomas, review the completed clinical trials, and discuss further directions in this field.

Recent Findings

Cancers including gliomas are characterized by derangements in cellular metabolism. In vitro and animal studies have revealed that dietary interventions to reduce glucose and glycolytic pathways in gliomas may have a therapeutic effect. Early trials in patients with malignant gliomas have shown feasibility, but are not robust enough yet to demonstrate clinical applicability.

Summary

Therapies for malignant gliomas of the brain are increasingly using a multi-targeted approach. The use of ketogenic diets and its variants may offer a unique and promising anti-glioma treatment by exploiting metabolic alterations seen in cancers including gliomas seen at the cellular level, which may work in concert with other therapies.
Title
Ketogenic Diet for Malignant Gliomas: a Review
Authors
Jonathan G. Thomas
Erol Veznedaroglu
Publication date
01-09-2020
Publisher
Springer US
Published in
Current Nutrition Reports / Issue 3/2020
Electronic ISSN: 2161-3311
DOI
https://doi.org/10.1007/s13668-020-00332-2
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Colon cancer illustration/© (M) KATERYNA KON / SCIENCE PHOTO LIBRARY / Getty Images, Human brain illustration/© (M) CHRISTOPH BURGSTEDT / SCIENCE PHOTO LIBRARY / Getty Images