Skip to main content
Top
Published in: Clinical Oral Investigations 11/2023

22-09-2023 | Gingival Diseases | Research

Antineoplastic therapy in childhood cancer patients presents a negative impact in the periodontal tissues: a cohort study

Authors: Bruna C. Longo, Isabel B. Rohling, Pauline L. M. O. E. Silva, Maria E. F. de Morais, Hélvis E. S. Paz, Renato C. V. Casarin, Sheila A. B. Nishiyama, Maria D. B. de Souza, Cléverson O. Silva

Published in: Clinical Oral Investigations | Issue 11/2023

Login to get access

Abstract

Objectives

To investigate the effect of antineoplastic therapy (AT) in the periodontal tissues of childhood cancer (CC) patients.

Materials and methods

Seventy-two individuals were divided into CC (n=36) and healthy individuals (control group—CG, n=36). Demographics, hygiene habits, CC type, and AT were collected. Salivary flow and the presence and concentration of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Tannerella forsythia, and Fusobacterium nucleatum were analyzed. Clinical evaluation included plaque (PI) and gingival indexes (GI), periodontal probing depth (PPD), and clinical attachment level (CAL). Patients were classified into periodontal health, gingivitis, or periodontitis. Descriptive statistics, T test, Mann-Whitney test, chi-square, Fisher’s exact test, and two-way analysis of variance were used (p<0.05).

Results

The mean age of the patients was similar (CC 12.0±3.9 years and CG 12.0±4.0 years). In the CC group, all patients underwent chemotherapy and nine radiotherapy. Color/race, income, and family education showed significant differences between groups. There was no difference between groups in salivary flow. Higher levels of Fusobacterium nucleatum were seen in CC (p=0.02). Significant difference between groups was found for PI (CC: 30.5%, CG: 22.6%), GI (CC: 28.8%, CG: 17.3%), PPD (CC: 1.77 mm, CG: 1.61 mm), and CAL (CC: 1.77 mm, CG: 1.57 mm), periodontal health (CC: 3, CG: 7), gingivitis (CC: 16, CG: 24), or periodontitis (CC: 17, CG: 5).

Conclusion

AT in CC patients presents a negative impact in the periodontal and microbiological parameters.

Clinical relevance

Childhood cancer individuals showed worse periodontal parameters and higher levels of Fusobacterium nucleatum in the saliva when compared to healthy individuals.
Literature
14.
go back to reference Shayani A, Aravena PC, Rodríguez-Salinas C, Escobar-Silva P, Diocares-Monsálvez Y, Angulo-Gutiérrez C, Rivera C (2022) Chemotherapy as a risk factor for caries and gingivitis in children with acute lymphoblastic leukemia: a retrospective cohort study. Int J Paediatr Dent 32:538–545. https://doi.org/10.1111/ipd.12932CrossRefPubMed Shayani A, Aravena PC, Rodríguez-Salinas C, Escobar-Silva P, Diocares-Monsálvez Y, Angulo-Gutiérrez C, Rivera C (2022) Chemotherapy as a risk factor for caries and gingivitis in children with acute lymphoblastic leukemia: a retrospective cohort study. Int J Paediatr Dent 32:538–545. https://​doi.​org/​10.​1111/​ipd.​12932CrossRefPubMed
22.
go back to reference Steliarova-Foucher E, Colombet M, Ries LAG, Rous B, Stiller CA (2017) Classification of tumours. In: Steliarova-Foucher E, Colombet M, Ries LAG, Moreno F, Dolya A, Shin HY, Hesseling P, Stiller CA (eds) International incidence of childhood cancer, vol III. International Agency for Research on Cancer, Lyon (In press). https://seer.cancer.gov/iccc/iccc-iarc-2017.html. Accessed 02 May 2021 Steliarova-Foucher E, Colombet M, Ries LAG, Rous B, Stiller CA (2017) Classification of tumours. In: Steliarova-Foucher E, Colombet M, Ries LAG, Moreno F, Dolya A, Shin HY, Hesseling P, Stiller CA (eds) International incidence of childhood cancer, vol III. International Agency for Research on Cancer, Lyon (In press). https://​seer.​cancer.​gov/​iccc/​iccc-iarc-2017.​html. Accessed 02 May 2021
25.
go back to reference Casarin RC, Peloso Ribeiro ED, Sallum EA, Nociti FH Jr, Gonçalves RB, Casati MZ (2012) The combination of amoxicillin and metronidazole improves clinical and microbiologic results of one-stage, full-mouth, ultrasonic debridement in aggressive periodontitis treatment. J Periodontol 83:988–998. https://doi.org/10.1902/jop.2012.110513CrossRefPubMed Casarin RC, Peloso Ribeiro ED, Sallum EA, Nociti FH Jr, Gonçalves RB, Casati MZ (2012) The combination of amoxicillin and metronidazole improves clinical and microbiologic results of one-stage, full-mouth, ultrasonic debridement in aggressive periodontitis treatment. J Periodontol 83:988–998. https://​doi.​org/​10.​1902/​jop.​2012.​110513CrossRefPubMed
26.
go back to reference Ainamo J, Bay I (1975) Problems and proposals for recording gingivitis and plaque. Int Dent J 25:229–235PubMed Ainamo J, Bay I (1975) Problems and proposals for recording gingivitis and plaque. Int Dent J 25:229–235PubMed
30.
go back to reference Little J (1999) Epidemiology of childhood cancer. IARC Scientific Publications No. 149, Oxford Little J (1999) Epidemiology of childhood cancer. IARC Scientific Publications No. 149, Oxford
34.
go back to reference Sonis AL, Tarbell N, Valachovic RW, Gelber R, Schwenn M, Sallan S (1990) Dentofacial development in long-term survivors of acute lymphoblastic leukemia. A comparison of three treatment modalities. Cancer 15:2645–2652CrossRef Sonis AL, Tarbell N, Valachovic RW, Gelber R, Schwenn M, Sallan S (1990) Dentofacial development in long-term survivors of acute lymphoblastic leukemia. A comparison of three treatment modalities. Cancer 15:2645–2652CrossRef
39.
go back to reference Sonis ST, Elting LS, Keefe D et al (2004) Mucositis study section of the multinational association for supportive care in cancer; international society for oral oncology. Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer 1:1995–2025. https://doi.org/10.1002/cncr.20162CrossRef Sonis ST, Elting LS, Keefe D et al (2004) Mucositis study section of the multinational association for supportive care in cancer; international society for oral oncology. Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer 1:1995–2025. https://​doi.​org/​10.​1002/​cncr.​20162CrossRef
Metadata
Title
Antineoplastic therapy in childhood cancer patients presents a negative impact in the periodontal tissues: a cohort study
Authors
Bruna C. Longo
Isabel B. Rohling
Pauline L. M. O. E. Silva
Maria E. F. de Morais
Hélvis E. S. Paz
Renato C. V. Casarin
Sheila A. B. Nishiyama
Maria D. B. de Souza
Cléverson O. Silva
Publication date
22-09-2023
Publisher
Springer Berlin Heidelberg
Published in
Clinical Oral Investigations / Issue 11/2023
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI
https://doi.org/10.1007/s00784-023-05270-1

Other articles of this Issue 11/2023

Clinical Oral Investigations 11/2023 Go to the issue