Skip to main content
Top

25-09-2024 | Invited Review Article

Generative AI and large language models in nuclear medicine: current status and future prospects

Authors: Kenji Hirata, Yusuke Matsui, Akira Yamada, Tomoyuki Fujioka, Masahiro Yanagawa, Takeshi Nakaura, Rintaro Ito, Daiju Ueda, Shohei Fujita, Fuminari Tatsugami, Yasutaka Fushimi, Takahiro Tsuboyama, Koji Kamagata, Taiki Nozaki, Noriyuki Fujima, Mariko Kawamura, Shinji Naganawa

Published in: Annals of Nuclear Medicine

Login to get access

Abstract

This review explores the potential applications of Large Language Models (LLMs) in nuclear medicine, especially nuclear medicine examinations such as PET and SPECT, reviewing recent advancements in both fields. Despite the rapid adoption of LLMs in various medical specialties, their integration into nuclear medicine has not yet been sufficiently explored. We first discuss the latest developments in nuclear medicine, including new radiopharmaceuticals, imaging techniques, and clinical applications. We then analyze how LLMs are being utilized in radiology, particularly in report generation, image interpretation, and medical education. We highlight the potential of LLMs to enhance nuclear medicine practices, such as improving report structuring, assisting in diagnosis, and facilitating research. However, challenges remain, including the need for improved reliability, explainability, and bias reduction in LLMs. The review also addresses the ethical considerations and potential limitations of AI in healthcare. In conclusion, LLMs have significant potential to transform existing frameworks in nuclear medicine, making it a critical area for future research and development.
Literature
1.
go back to reference Nakaura T, Ito R, Ueda D, Nozaki T, Fushimi Y, Matsui Y, et al. The impact of large language models on radiology: a guide for radiologists on the latest innovations in AI. Jpn J Radiol. 2024;42:685–96.PubMedPubMedCentralCrossRef Nakaura T, Ito R, Ueda D, Nozaki T, Fushimi Y, Matsui Y, et al. The impact of large language models on radiology: a guide for radiologists on the latest innovations in AI. Jpn J Radiol. 2024;42:685–96.PubMedPubMedCentralCrossRef
3.
go back to reference Nakaura T, Yoshida N, Kobayashi N, Shiraishi K, Nagayama Y, Uetani H, et al. Preliminary assessment of automated radiology report generation with generative pre-trained transformers: comparing results to radiologist-generated reports. Jpn J Radiol. 2024;42:190–200.PubMedCrossRef Nakaura T, Yoshida N, Kobayashi N, Shiraishi K, Nagayama Y, Uetani H, et al. Preliminary assessment of automated radiology report generation with generative pre-trained transformers: comparing results to radiologist-generated reports. Jpn J Radiol. 2024;42:190–200.PubMedCrossRef
4.
go back to reference Nakaura T, Hirai T. Response to Letter to the Editor from Partha Pratim Ray: “Integrating AI in radiology: insights from GPT-generated reports and multimodal LLM performance on European Board of Radiology examinations.” Jpn J Radiol [Internet]. 2024; Available from: https://pubmed.ncbi.nlm.nih.gov/39002023/ Nakaura T, Hirai T. Response to Letter to the Editor from Partha Pratim Ray: “Integrating AI in radiology: insights from GPT-generated reports and multimodal LLM performance on European Board of Radiology examinations.” Jpn J Radiol [Internet]. 2024; Available from: https://​pubmed.​ncbi.​nlm.​nih.​gov/​39002023/​
9.
go back to reference Alberts IL, Mercolli L, Pyka T, Prenosil G, Shi K, Rominger A, et al. Large language models (LLM) and ChatGPT: what will the impact on nuclear medicine be? Eur J Nucl Med Mol Imaging. 2023;50:1549–52.PubMedPubMedCentralCrossRef Alberts IL, Mercolli L, Pyka T, Prenosil G, Shi K, Rominger A, et al. Large language models (LLM) and ChatGPT: what will the impact on nuclear medicine be? Eur J Nucl Med Mol Imaging. 2023;50:1549–52.PubMedPubMedCentralCrossRef
10.
go back to reference Okizaki A, Nishiyama Y, Inui Y, Otsuka H, Takanami K, Nakajo M, et al. Nuclear medicine practice in Japan: a report of the ninth nationwide survey in 2022. Ann Nucl Med. 2024;38:315–27.PubMedCrossRef Okizaki A, Nishiyama Y, Inui Y, Otsuka H, Takanami K, Nakajo M, et al. Nuclear medicine practice in Japan: a report of the ninth nationwide survey in 2022. Ann Nucl Med. 2024;38:315–27.PubMedCrossRef
12.
go back to reference Rao W, Fang X-H, Zhao Y, Wang Y, Zhang B, Wei Z, et al. Clinical value of [18F]AlF-NOTA-FAPI-04 PET/CT for assessing early-stage liver fibrosis in adult liver transplantation recipients compared with chronic HBV patients. Jpn J Radiol. 2024;42:536–45.PubMedCrossRef Rao W, Fang X-H, Zhao Y, Wang Y, Zhang B, Wei Z, et al. Clinical value of [18F]AlF-NOTA-FAPI-04 PET/CT for assessing early-stage liver fibrosis in adult liver transplantation recipients compared with chronic HBV patients. Jpn J Radiol. 2024;42:536–45.PubMedCrossRef
13.
go back to reference Hirata K, Watanabe S, Kitagawa Y, Kudo K. A review of hypoxia imaging using 18F-fluoromisonidazole positron emission tomography. Methods Mol Biol. 2024;2755:133–40.PubMedCrossRef Hirata K, Watanabe S, Kitagawa Y, Kudo K. A review of hypoxia imaging using 18F-fluoromisonidazole positron emission tomography. Methods Mol Biol. 2024;2755:133–40.PubMedCrossRef
15.
go back to reference Kuroshima T, Kitagawa Y, Sato J, Watanabe S, Asaka T, Abe T, et al. Maximum standardized uptake value in 11C-methionine positron emission tomography may predict the prognosis of patients with oral squamous cell carcinoma. Odontology [Internet]. 2024; Available from: https://pubmed.ncbi.nlm.nih.gov/38703257/ Kuroshima T, Kitagawa Y, Sato J, Watanabe S, Asaka T, Abe T, et al. Maximum standardized uptake value in 11C-methionine positron emission tomography may predict the prognosis of patients with oral squamous cell carcinoma. Odontology [Internet]. 2024; Available from: https://​pubmed.​ncbi.​nlm.​nih.​gov/​38703257/​
17.
go back to reference Xie Y, Teng Y, Jiang C, Ding C, Zhou Z. Prognostic value of 18F-FDG lesion dissemination features in patients with peripheral T-cell lymphoma (PTCL). Jpn J Radiol. 2023;41:777–86.PubMedCrossRef Xie Y, Teng Y, Jiang C, Ding C, Zhou Z. Prognostic value of 18F-FDG lesion dissemination features in patients with peripheral T-cell lymphoma (PTCL). Jpn J Radiol. 2023;41:777–86.PubMedCrossRef
18.
go back to reference He L, Chen Y, Tan X, Sun X, Zhang Q, Luo H, et al. 18F-FDG PET/CT and contrast-enhanced CT in the diagnosis of Castleman disease. Jpn J Radiol. 2023;41:98–107.PubMedCrossRef He L, Chen Y, Tan X, Sun X, Zhang Q, Luo H, et al. 18F-FDG PET/CT and contrast-enhanced CT in the diagnosis of Castleman disease. Jpn J Radiol. 2023;41:98–107.PubMedCrossRef
19.
go back to reference Yoldaş B, Gürsoy S, Budak E, Gülmez B, Ceylan KC, Çırak AK, et al. FDG PET/CT signs of proven pulmonary hydatid cyst: is there any clue? Jpn J Radiol. 2022;40:1194–200.PubMedCrossRef Yoldaş B, Gürsoy S, Budak E, Gülmez B, Ceylan KC, Çırak AK, et al. FDG PET/CT signs of proven pulmonary hydatid cyst: is there any clue? Jpn J Radiol. 2022;40:1194–200.PubMedCrossRef
20.
go back to reference Bedmutha AS, Agrawal A, Rangarajan V, Goel M, Patkar S, Puranik AD, et al. Diagnostic performance of F-18 FDG PET/CT in recurrent adenocarcinoma gallbladder and its impact on post-recurrence survival. Jpn J Radiol. 2023;41:201–8.PubMedCrossRef Bedmutha AS, Agrawal A, Rangarajan V, Goel M, Patkar S, Puranik AD, et al. Diagnostic performance of F-18 FDG PET/CT in recurrent adenocarcinoma gallbladder and its impact on post-recurrence survival. Jpn J Radiol. 2023;41:201–8.PubMedCrossRef
21.
go back to reference Li Q, Li Y, Yuan H, Yang F, Huang Y, Song X, et al. PET morphology helps distinguish solitary and solid pulmonary tuberculosis from non-small cell lung cancer. Jpn J Radiol. 2023;41:312–21.PubMed Li Q, Li Y, Yuan H, Yang F, Huang Y, Song X, et al. PET morphology helps distinguish solitary and solid pulmonary tuberculosis from non-small cell lung cancer. Jpn J Radiol. 2023;41:312–21.PubMed
22.
go back to reference Tamaki N, Hirata K, Kotani T, Nakai Y, Matsushima S, Yamada K. Four-dimensional quantitative analysis using FDG-PET in clinical oncology. Jpn J Radiol. 2023;41:831–42.PubMedPubMedCentralCrossRef Tamaki N, Hirata K, Kotani T, Nakai Y, Matsushima S, Yamada K. Four-dimensional quantitative analysis using FDG-PET in clinical oncology. Jpn J Radiol. 2023;41:831–42.PubMedPubMedCentralCrossRef
23.
go back to reference Kaji T, Osanai K, Takahashi A, Kinoshita A, Satoh D, Nakata T, et al. Improvement of motion artifacts using dynamic whole-body 18F-FDG PET/CT imaging. Jpn J Radiol. 2024;42:374–81.PubMedCrossRef Kaji T, Osanai K, Takahashi A, Kinoshita A, Satoh D, Nakata T, et al. Improvement of motion artifacts using dynamic whole-body 18F-FDG PET/CT imaging. Jpn J Radiol. 2024;42:374–81.PubMedCrossRef
24.
go back to reference Ni M, Wang S, Liu X, Shi Q, Zhu X, Zhang Y, et al. Predictive value of intratumor metabolic and heterogeneity parameters on [18F]FDG PET/CT for EGFR mutations in patients with lung adenocarcinoma. Jpn J Radiol. 2023;41:209–18.PubMedCrossRef Ni M, Wang S, Liu X, Shi Q, Zhu X, Zhang Y, et al. Predictive value of intratumor metabolic and heterogeneity parameters on [18F]FDG PET/CT for EGFR mutations in patients with lung adenocarcinoma. Jpn J Radiol. 2023;41:209–18.PubMedCrossRef
25.
go back to reference Yamane T, Matsusaka Y, Fukushima K, Seto A, Matsunari I, Kuji I. Atlas of non-pathological solitary or asymmetrical skeletal muscle uptake in [18F]FDG-PET. Jpn J Radiol. 2022;40:755–67.PubMedPubMedCentralCrossRef Yamane T, Matsusaka Y, Fukushima K, Seto A, Matsunari I, Kuji I. Atlas of non-pathological solitary or asymmetrical skeletal muscle uptake in [18F]FDG-PET. Jpn J Radiol. 2022;40:755–67.PubMedPubMedCentralCrossRef
26.
go back to reference Iritani Y, Kato H, Kaneko Y, Ishihara T, Ando T, Kawaguchi M, et al. FDG uptake in the cervical muscles after neck dissection: imaging features and postoperative natural course on 18F-FDG-PET/CT. Jpn J Radiol. 2024;42:892–8.PubMedPubMedCentralCrossRef Iritani Y, Kato H, Kaneko Y, Ishihara T, Ando T, Kawaguchi M, et al. FDG uptake in the cervical muscles after neck dissection: imaging features and postoperative natural course on 18F-FDG-PET/CT. Jpn J Radiol. 2024;42:892–8.PubMedPubMedCentralCrossRef
27.
go back to reference Minamimoto R. Optimal use of the FDG-PET/CT in the diagnostic process of fever of unknown origin (FUO): a comprehensive review. Jpn J Radiol. 2022;40:1121–37.PubMedPubMedCentralCrossRef Minamimoto R. Optimal use of the FDG-PET/CT in the diagnostic process of fever of unknown origin (FUO): a comprehensive review. Jpn J Radiol. 2022;40:1121–37.PubMedPubMedCentralCrossRef
28.
go back to reference Kitajima K, Watabe T, Nakajo M, Ishibashi M, Daisaki H, Soeda F, et al. Tumor response evaluation in patients with malignant melanoma undergoing immune checkpoint inhibitor therapy and prognosis prediction using 18F-FDG PET/CT: multicenter study for comparison of EORTC, PERCIST, and imPERCIST. Jpn J Radiol. 2022;40:75–85.PubMedCrossRef Kitajima K, Watabe T, Nakajo M, Ishibashi M, Daisaki H, Soeda F, et al. Tumor response evaluation in patients with malignant melanoma undergoing immune checkpoint inhibitor therapy and prognosis prediction using 18F-FDG PET/CT: multicenter study for comparison of EORTC, PERCIST, and imPERCIST. Jpn J Radiol. 2022;40:75–85.PubMedCrossRef
29.
go back to reference Shen L-F, Fu Z-M, Zhou S-H. The role of radiotherapy in tumor immunity and the potential of PET/CT in detecting the expression of PD-1/PD-L1. Jpn J Radiol. 2024;42:347–53.PubMedCrossRef Shen L-F, Fu Z-M, Zhou S-H. The role of radiotherapy in tumor immunity and the potential of PET/CT in detecting the expression of PD-1/PD-L1. Jpn J Radiol. 2024;42:347–53.PubMedCrossRef
30.
go back to reference Gideonse BM, Birkeland M, Vilstrup MH, Grupe P, Naghavi-Behzad M, Ruhlmann CH, et al. Organ-specific accuracy of [18F]FDG-PET/CT in identifying immune-related adverse events in patients with high-risk melanoma treated with adjuvant immune checkpoint inhibitor. Jpn J Radiol. 2024;42:753–64.PubMedPubMedCentralCrossRef Gideonse BM, Birkeland M, Vilstrup MH, Grupe P, Naghavi-Behzad M, Ruhlmann CH, et al. Organ-specific accuracy of [18F]FDG-PET/CT in identifying immune-related adverse events in patients with high-risk melanoma treated with adjuvant immune checkpoint inhibitor. Jpn J Radiol. 2024;42:753–64.PubMedPubMedCentralCrossRef
31.
go back to reference Nakajo M, Horizoe Y, Kawaji K, Jinguji M, Tani A, Fukukura Y, et al. Application of 123I-MIBG myocardial maximum standardized uptake value to characterize cardiac function in patients with pheochromocytoma: comparison with echocardiography. Jpn J Radiol. 2023;41:437–48.PubMedCrossRef Nakajo M, Horizoe Y, Kawaji K, Jinguji M, Tani A, Fukukura Y, et al. Application of 123I-MIBG myocardial maximum standardized uptake value to characterize cardiac function in patients with pheochromocytoma: comparison with echocardiography. Jpn J Radiol. 2023;41:437–48.PubMedCrossRef
32.
go back to reference Moridera K, Kitajima K, Yoshikawa K, Takaoka K, Tsuchitani T, Noguchi K, et al. Usefulness of quantitative bone SPECT/CT for evaluating medication-related osteonecrosis of the jaw treatment response. Jpn J Radiol. 2023;41:760–7.PubMedCrossRef Moridera K, Kitajima K, Yoshikawa K, Takaoka K, Tsuchitani T, Noguchi K, et al. Usefulness of quantitative bone SPECT/CT for evaluating medication-related osteonecrosis of the jaw treatment response. Jpn J Radiol. 2023;41:760–7.PubMedCrossRef
33.
go back to reference Zhang M, Yang W, Yuan Y, Liu Z, Yue X, Cao X, et al. Diagnostic potential of [18F]FDG PET/MRI in non-small cell lung cancer lymph node metastasis: a meta-analysis. Jpn J Radiol. 2024;42:87–95.PubMedCrossRef Zhang M, Yang W, Yuan Y, Liu Z, Yue X, Cao X, et al. Diagnostic potential of [18F]FDG PET/MRI in non-small cell lung cancer lymph node metastasis: a meta-analysis. Jpn J Radiol. 2024;42:87–95.PubMedCrossRef
34.
go back to reference Ono T, Ichikawa M, Tanada T, Kanezawa C, Sato H. Maximum tumor diameter and renal function can predict the declining surface dose rate after 177Lu-Dotatate: preliminary results of single institution in Japan. Jpn J Radiol [Internet]. 2024; Available from: https://pubmed.ncbi.nlm.nih.gov/38727960/ Ono T, Ichikawa M, Tanada T, Kanezawa C, Sato H. Maximum tumor diameter and renal function can predict the declining surface dose rate after 177Lu-Dotatate: preliminary results of single institution in Japan. Jpn J Radiol [Internet]. 2024; Available from: https://​pubmed.​ncbi.​nlm.​nih.​gov/​38727960/​
35.
go back to reference Okajima Y, Yanagisawa S, Yamada A, Notake T, Shimizu A, Soejima Y, et al. Predictability of combining Technetium-99m-galactosyl human serum albumin single-photon emission computed tomography/computed tomography and indocyanine green clearance test for posthepatectomy liver failure. Jpn J Radiol [Internet]. 2024; Available from: https://pubmed.ncbi.nlm.nih.gov/38913284/ Okajima Y, Yanagisawa S, Yamada A, Notake T, Shimizu A, Soejima Y, et al. Predictability of combining Technetium-99m-galactosyl human serum albumin single-photon emission computed tomography/computed tomography and indocyanine green clearance test for posthepatectomy liver failure. Jpn J Radiol [Internet]. 2024; Available from: https://​pubmed.​ncbi.​nlm.​nih.​gov/​38913284/​
36.
go back to reference Hirasawa H, Taketomi-Takahashi A, Katsumata N, Higuchi T, Sekine Y, Suzuki K, et al. Efficacy of 18F-Fluorodeoxyglucose positron emission tomography/computed tomography for detecting renal cell carcinoma in patients with end-stage renal disease. Jpn J Radiol [Internet]. 2024; Available from: https://pubmed.ncbi.nlm.nih.gov/38795287/ Hirasawa H, Taketomi-Takahashi A, Katsumata N, Higuchi T, Sekine Y, Suzuki K, et al. Efficacy of 18F-Fluorodeoxyglucose positron emission tomography/computed tomography for detecting renal cell carcinoma in patients with end-stage renal disease. Jpn J Radiol [Internet]. 2024; Available from: https://​pubmed.​ncbi.​nlm.​nih.​gov/​38795287/​
38.
go back to reference Odano I, Maeyatsu F, Hosoya T, Asari M, Oba K, Taki Y. Diagnostic approach with Z-score mapping to reduce artifacts caused by cerebral atrophy in regional CBF assessment of mild cognitive impairment (MCI) and Alzheimer’s disease by [99mTc]-ECD and SPECT. Jpn J Radiol. 2024;42:508–18.PubMedPubMedCentralCrossRef Odano I, Maeyatsu F, Hosoya T, Asari M, Oba K, Taki Y. Diagnostic approach with Z-score mapping to reduce artifacts caused by cerebral atrophy in regional CBF assessment of mild cognitive impairment (MCI) and Alzheimer’s disease by [99mTc]-ECD and SPECT. Jpn J Radiol. 2024;42:508–18.PubMedPubMedCentralCrossRef
39.
go back to reference Yamamoto M, Inada T. Positron emission tomography studies in adult patients with attention-deficit/hyperactivity disorder. Jpn J Radiol. 2023;41:382–92.PubMedCrossRef Yamamoto M, Inada T. Positron emission tomography studies in adult patients with attention-deficit/hyperactivity disorder. Jpn J Radiol. 2023;41:382–92.PubMedCrossRef
40.
go back to reference Lee T-H, Wang Y-F, Hu L-H, Peng N-J, Chang C-Y, Huang W-S. Follow-up Tc-99 m pyrophosphate cardiac scan for patients with transthyretin cardiac amyloidosis treated with tafamidis. Jpn J Radiol. 2023;41:882–8.PubMedCrossRef Lee T-H, Wang Y-F, Hu L-H, Peng N-J, Chang C-Y, Huang W-S. Follow-up Tc-99 m pyrophosphate cardiac scan for patients with transthyretin cardiac amyloidosis treated with tafamidis. Jpn J Radiol. 2023;41:882–8.PubMedCrossRef
41.
go back to reference Matsuda N, Otsuka H, Otani T, Azane S, Kunikane Y, Otomi Y, et al. New quantitative indices of cardiac amyloidosis with 99mTc-pyrophosphate scintigraphy. Jpn J Radiol. 2023;41:428–36.PubMedCrossRef Matsuda N, Otsuka H, Otani T, Azane S, Kunikane Y, Otomi Y, et al. New quantitative indices of cardiac amyloidosis with 99mTc-pyrophosphate scintigraphy. Jpn J Radiol. 2023;41:428–36.PubMedCrossRef
42.
go back to reference Ogasawara K, Shiraishi S, Tsuda N, Sakamoto F, Oda S, Takashio S, et al. Usefulness of quantitative 99mTc-pyrophosphate SPECT/CT for predicting the prognosis of patients with wild-type transthyretin cardiac amyloidosis. Jpn J Radiol. 2022;40:508–17.PubMedPubMedCentralCrossRef Ogasawara K, Shiraishi S, Tsuda N, Sakamoto F, Oda S, Takashio S, et al. Usefulness of quantitative 99mTc-pyrophosphate SPECT/CT for predicting the prognosis of patients with wild-type transthyretin cardiac amyloidosis. Jpn J Radiol. 2022;40:508–17.PubMedPubMedCentralCrossRef
43.
go back to reference Iwasa H, Nagamachi S, Nakayama S, Yamamoto T, Yoshimitsu K. The reproducibility of MTV and TLG of soft tissue tumors calculated by FDG-PET: Comparison between the lower limit by the fixed value SUV 25 and that value by 30% of SUVmax. Jpn J Radiol. 2023;41:531–40.PubMedPubMedCentralCrossRef Iwasa H, Nagamachi S, Nakayama S, Yamamoto T, Yoshimitsu K. The reproducibility of MTV and TLG of soft tissue tumors calculated by FDG-PET: Comparison between the lower limit by the fixed value SUV 25 and that value by 30% of SUVmax. Jpn J Radiol. 2023;41:531–40.PubMedPubMedCentralCrossRef
44.
go back to reference Yuan H, Wang F, He S, Xiang Z, Zhang X, Jiang L. SUVmean ratios of liver/muscle and lung/muscle from 13N-NH3 PET perfusion outperformed traditional myocardial viability parameters in predicting survival after CABG. Jpn J Radiol [Internet]. 2024; Available from: https://pubmed.ncbi.nlm.nih.gov/38856879/ Yuan H, Wang F, He S, Xiang Z, Zhang X, Jiang L. SUVmean ratios of liver/muscle and lung/muscle from 13N-NH3 PET perfusion outperformed traditional myocardial viability parameters in predicting survival after CABG. Jpn J Radiol [Internet]. 2024; Available from: https://​pubmed.​ncbi.​nlm.​nih.​gov/​38856879/​
45.
go back to reference Nishimori M, Iwasa H, Nakaji K, Nitta N, Miyatake K, Yoshimatsu R, et al. Predicting the pathological invasiveness of early lung adenocarcinoma prior to surgery using Deauville criteria: reliability and validity. Jpn J Radiol. 2023;41:768–76.PubMedPubMedCentralCrossRef Nishimori M, Iwasa H, Nakaji K, Nitta N, Miyatake K, Yoshimatsu R, et al. Predicting the pathological invasiveness of early lung adenocarcinoma prior to surgery using Deauville criteria: reliability and validity. Jpn J Radiol. 2023;41:768–76.PubMedPubMedCentralCrossRef
46.
go back to reference Hamabuchi N, Ohno Y, Kimata H, Ito Y, Fujii K, Akino N, et al. Effectiveness of deep learning reconstruction on standard to ultra-low-dose high-definition chest CT images. Jpn J Radiol. 2023;41:1373–88.PubMedPubMedCentralCrossRef Hamabuchi N, Ohno Y, Kimata H, Ito Y, Fujii K, Akino N, et al. Effectiveness of deep learning reconstruction on standard to ultra-low-dose high-definition chest CT images. Jpn J Radiol. 2023;41:1373–88.PubMedPubMedCentralCrossRef
48.
go back to reference Nai Y-H, Loi HY, O’Doherty S, Tan TH, Reilhac A. Comparison of the performances of machine learning and deep learning in improving the quality of low dose lung cancer PET images. Jpn J Radiol. 2022;40:1290–9.PubMedCrossRef Nai Y-H, Loi HY, O’Doherty S, Tan TH, Reilhac A. Comparison of the performances of machine learning and deep learning in improving the quality of low dose lung cancer PET images. Jpn J Radiol. 2022;40:1290–9.PubMedCrossRef
49.
go back to reference Yasuda T, Honda T, Utano K, Kato T, Togashi K, Yamaguchi S, et al. Diagnostic accuracy of ultra-low-dose CT colonography for the detection of colorectal polyps: a feasibility study. Jpn J Radiol. 2022;40:831–9.PubMedCrossRef Yasuda T, Honda T, Utano K, Kato T, Togashi K, Yamaguchi S, et al. Diagnostic accuracy of ultra-low-dose CT colonography for the detection of colorectal polyps: a feasibility study. Jpn J Radiol. 2022;40:831–9.PubMedCrossRef
50.
51.
go back to reference Hou Z, Kong Y, Wu J, Gu J, Liu J, Gao S, et al. A deep learning model for translating CT to ventilation imaging: analysis of accuracy and impact on functional avoidance radiotherapy planning. Jpn J Radiol. 2024;42:765–76.PubMedCrossRef Hou Z, Kong Y, Wu J, Gu J, Liu J, Gao S, et al. A deep learning model for translating CT to ventilation imaging: analysis of accuracy and impact on functional avoidance radiotherapy planning. Jpn J Radiol. 2024;42:765–76.PubMedCrossRef
52.
go back to reference Fusco R, Granata V, Grazzini G, Pradella S, Borgheresi A, Bruno A, et al. Radiomics in medical imaging: pitfalls and challenges in clinical management. Jpn J Radiol. 2022;40:919–29.PubMedCrossRef Fusco R, Granata V, Grazzini G, Pradella S, Borgheresi A, Bruno A, et al. Radiomics in medical imaging: pitfalls and challenges in clinical management. Jpn J Radiol. 2022;40:919–29.PubMedCrossRef
55.
go back to reference Tie X, Shin M, Pirasteh A, Ibrahim N, Huemann Z, Castellino SM, et al. Personalized impression generation for PET reports using large language models. J Imaging Inform Med. 2024;37:471–88.PubMedPubMedCentralCrossRef Tie X, Shin M, Pirasteh A, Ibrahim N, Huemann Z, Castellino SM, et al. Personalized impression generation for PET reports using large language models. J Imaging Inform Med. 2024;37:471–88.PubMedPubMedCentralCrossRef
56.
go back to reference López-Úbeda P, Martín-Noguerol T, Díaz-Angulo C, Luna A. Evaluation of large language models performance against humans for summarizing MRI knee radiology reports: A feasibility study. Int J Med Inform. 2024;187: 105443.PubMedCrossRef López-Úbeda P, Martín-Noguerol T, Díaz-Angulo C, Luna A. Evaluation of large language models performance against humans for summarizing MRI knee radiology reports: A feasibility study. Int J Med Inform. 2024;187: 105443.PubMedCrossRef
57.
go back to reference Kaya K, Gietzen C, Hahnfeldt R, Zoubi M, Emrich T, Halfmann MC, et al. GPT-4 analysis of MRI reports in suspected myocarditis: a multicenter study. J Cardiovasc Magn Reson. 2024;26:101068.PubMedPubMedCentralCrossRef Kaya K, Gietzen C, Hahnfeldt R, Zoubi M, Emrich T, Halfmann MC, et al. GPT-4 analysis of MRI reports in suspected myocarditis: a multicenter study. J Cardiovasc Magn Reson. 2024;26:101068.PubMedPubMedCentralCrossRef
58.
62.
go back to reference Noguchi T, Yamashita K, Matsuura S, Kamei R, Maehara J, Furuya K, et al. Analysis of “visible in retrospect” to monitor false-negative findings in radiological reports. Jpn J Radiol. 2023;41:219–27.PubMedCrossRef Noguchi T, Yamashita K, Matsuura S, Kamei R, Maehara J, Furuya K, et al. Analysis of “visible in retrospect” to monitor false-negative findings in radiological reports. Jpn J Radiol. 2023;41:219–27.PubMedCrossRef
63.
go back to reference Takagi S, Watari T, Erabi A, Sakaguchi K. Performance of GPT-35 and GPT-4 on the Japanese medical licensing examination: comparison study. JMIR Med Educ. 2023;9:48002.CrossRef Takagi S, Watari T, Erabi A, Sakaguchi K. Performance of GPT-35 and GPT-4 on the Japanese medical licensing examination: comparison study. JMIR Med Educ. 2023;9:48002.CrossRef
64.
go back to reference Toyama Y, Harigai A, Abe M, Nagano M, Kawabata M, Seki Y, et al. Performance evaluation of ChatGPT, GPT-4, and Bard on the official board examination of the Japan Radiology Society. Jpn J Radiol. 2024;42:201–7.PubMedCrossRef Toyama Y, Harigai A, Abe M, Nagano M, Kawabata M, Seki Y, et al. Performance evaluation of ChatGPT, GPT-4, and Bard on the official board examination of the Japan Radiology Society. Jpn J Radiol. 2024;42:201–7.PubMedCrossRef
65.
go back to reference Hirano Y, Hanaoka S, Nakao T, Miki S, Kikuchi T, Nakamura Y, et al. GPT-4 Turbo with vision fails to outperform text-only GPT-4 Turbo in the Japan diagnostic radiology board examination. Jpn J Radiol. 2024;42:918–26.PubMedPubMedCentralCrossRef Hirano Y, Hanaoka S, Nakao T, Miki S, Kikuchi T, Nakamura Y, et al. GPT-4 Turbo with vision fails to outperform text-only GPT-4 Turbo in the Japan diagnostic radiology board examination. Jpn J Radiol. 2024;42:918–26.PubMedPubMedCentralCrossRef
66.
go back to reference Adams LC, Truhn D, Busch F, Dorfner F, Nawabi J, Makowski MR, et al. Llama 3 challenges proprietary state-of-the-art large language models in radiology board-style examination questions. Radiology. 2024;312: e241191.PubMedCrossRef Adams LC, Truhn D, Busch F, Dorfner F, Nawabi J, Makowski MR, et al. Llama 3 challenges proprietary state-of-the-art large language models in radiology board-style examination questions. Radiology. 2024;312: e241191.PubMedCrossRef
67.
go back to reference Beşler MS. The performance of the multimodal large language model GPT-4 on the European board of radiology examination sample test. Jpn J Radiol. 2024;42:927.PubMedCrossRef Beşler MS. The performance of the multimodal large language model GPT-4 on the European board of radiology examination sample test. Jpn J Radiol. 2024;42:927.PubMedCrossRef
69.
go back to reference Kufel J, Paszkiewicz I, Bielówka M, Bartnikowska W, Janik M, Stencel M, et al. Will ChatGPT pass the Polish specialty exam in radiology and diagnostic imaging? Insights into strengths and limitations. Pol J Radiol. 2023;88:e430–4.PubMedPubMedCentralCrossRef Kufel J, Paszkiewicz I, Bielówka M, Bartnikowska W, Janik M, Stencel M, et al. Will ChatGPT pass the Polish specialty exam in radiology and diagnostic imaging? Insights into strengths and limitations. Pol J Radiol. 2023;88:e430–4.PubMedPubMedCentralCrossRef
70.
go back to reference Suthar PP, Kounsal A, Chhetri L, Saini D, Dua SG. Artificial intelligence (AI) in radiology: A deep dive into ChatGPT 4.0’s accuracy with the American Journal of Neuroradiology’s (AJNR) “Case of the Month.” Cureus. 2023;15:43958. Suthar PP, Kounsal A, Chhetri L, Saini D, Dua SG. Artificial intelligence (AI) in radiology: A deep dive into ChatGPT 4.0’s accuracy with the American Journal of Neuroradiology’s (AJNR) “Case of the Month.” Cureus. 2023;15:43958.
72.
go back to reference Doi K, Takegawa H, Yui M, Anetai Y, Koike Y, Nakamura S, et al. Deep learning-based detection of patients with bone metastasis from Japanese radiology reports. Jpn J Radiol. 2023;41:900–8.PubMedCrossRef Doi K, Takegawa H, Yui M, Anetai Y, Koike Y, Nakamura S, et al. Deep learning-based detection of patients with bone metastasis from Japanese radiology reports. Jpn J Radiol. 2023;41:900–8.PubMedCrossRef
73.
go back to reference Fink MA, Bischoff A, Fink CA, Moll M, Kroschke J, Dulz L, et al. Potential of ChatGPT and GPT-4 for data mining of free-text CT reports on lung cancer. Radiology. 2023;308: e231362.PubMedCrossRef Fink MA, Bischoff A, Fink CA, Moll M, Kroschke J, Dulz L, et al. Potential of ChatGPT and GPT-4 for data mining of free-text CT reports on lung cancer. Radiology. 2023;308: e231362.PubMedCrossRef
75.
go back to reference Zhong J, Xing Y, Hu Y, Lu J, Yang J, Zhang G, et al. The policies on the use of large language models in radiological journals are lacking: a meta-research study. Insights Imaging. 2024;15:186.PubMedPubMedCentralCrossRef Zhong J, Xing Y, Hu Y, Lu J, Yang J, Zhang G, et al. The policies on the use of large language models in radiological journals are lacking: a meta-research study. Insights Imaging. 2024;15:186.PubMedPubMedCentralCrossRef
76.
go back to reference Gong EJ, Bang CS. Evaluating the role of large language models in inflammatory bowel disease patient information. World J Gastroenterol. 2024;30:3538–40.PubMedPubMedCentralCrossRef Gong EJ, Bang CS. Evaluating the role of large language models in inflammatory bowel disease patient information. World J Gastroenterol. 2024;30:3538–40.PubMedPubMedCentralCrossRef
77.
go back to reference Bhayana R. Chatbots and large language models in radiology: a practical primer for clinical and research applications. Radiology. 2024;310: e232756.PubMedCrossRef Bhayana R. Chatbots and large language models in radiology: a practical primer for clinical and research applications. Radiology. 2024;310: e232756.PubMedCrossRef
79.
go back to reference Doo FX, Kulkarni P, Siegel EL, Toland M, Yi PH, Carlos RC, et al. Economic and environmental costs of cloud technologies for medical imaging and radiology artificial intelligence. J Am Coll Radiol. 2024;21:248–56.PubMedCrossRef Doo FX, Kulkarni P, Siegel EL, Toland M, Yi PH, Carlos RC, et al. Economic and environmental costs of cloud technologies for medical imaging and radiology artificial intelligence. J Am Coll Radiol. 2024;21:248–56.PubMedCrossRef
80.
go back to reference Wang Y, Liang L, Li R, Wang Y, Hao C. Comparison of the performance of ChatGPT, Claude and bard in support of myopia prevention and control. J Multidiscip Healthc. 2024;17:3917–29.PubMedPubMedCentralCrossRef Wang Y, Liang L, Li R, Wang Y, Hao C. Comparison of the performance of ChatGPT, Claude and bard in support of myopia prevention and control. J Multidiscip Healthc. 2024;17:3917–29.PubMedPubMedCentralCrossRef
81.
go back to reference Irmici G, Cozzi A, Della Pepa G, De Berardinis C, D’Ascoli E, Cellina M, et al. How do large language models answer breast cancer quiz questions? A comparative study of GPT-3.5, GPT-4 and Google Gemini. Radiol Med [Internet]. 2024; Available from: https://pubmed.ncbi.nlm.nih.gov/39138732/ Irmici G, Cozzi A, Della Pepa G, De Berardinis C, D’Ascoli E, Cellina M, et al. How do large language models answer breast cancer quiz questions? A comparative study of GPT-3.5, GPT-4 and Google Gemini. Radiol Med [Internet]. 2024; Available from: https://​pubmed.​ncbi.​nlm.​nih.​gov/​39138732/​
82.
go back to reference Kurokawa R, Ohizumi Y, Kanzawa J, Kurokawa M, Sonoda Y, Nakamura Y, et al. Diagnostic performances of Claude 3 Opus and Claude 3.5 Sonnet from patient history and key images in Radiology’s “Diagnosis Please” cases. Jpn J Radiol [Internet]. 2024; Available from: https://pubmed.ncbi.nlm.nih.gov/39096483/ Kurokawa R, Ohizumi Y, Kanzawa J, Kurokawa M, Sonoda Y, Nakamura Y, et al. Diagnostic performances of Claude 3 Opus and Claude 3.5 Sonnet from patient history and key images in Radiology’s “Diagnosis Please” cases. Jpn J Radiol [Internet]. 2024; Available from: https://​pubmed.​ncbi.​nlm.​nih.​gov/​39096483/​
83.
go back to reference Currie G, Robbie S, Tually P. ChatGPT and patient information in nuclear medicine: GPT-3.5 versus GPT-4. J Nucl Med Technol. 2023;51:307–13. Currie G, Robbie S, Tually P. ChatGPT and patient information in nuclear medicine: GPT-3.5 versus GPT-4. J Nucl Med Technol. 2023;51:307–13.
84.
Metadata
Title
Generative AI and large language models in nuclear medicine: current status and future prospects
Authors
Kenji Hirata
Yusuke Matsui
Akira Yamada
Tomoyuki Fujioka
Masahiro Yanagawa
Takeshi Nakaura
Rintaro Ito
Daiju Ueda
Shohei Fujita
Fuminari Tatsugami
Yasutaka Fushimi
Takahiro Tsuboyama
Koji Kamagata
Taiki Nozaki
Noriyuki Fujima
Mariko Kawamura
Shinji Naganawa
Publication date
25-09-2024
Publisher
Springer Nature Singapore
Published in
Annals of Nuclear Medicine
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-024-01981-x