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Gastroenterology and Hepatology

Case Studies

Isotretinoin-induced pancreatitis

Isotretinoin was stopped as a precaution in a young man who suffered several episodes of acute pancreatitis. Recurrence after rechallenge suggests isotretinoin should be recognized as a class 1 pancreaticotoxic drug.

Gastric adenomas caused by long-term PPI use?

A patient who tested negative for H. pylori and who had been taking a proton pump inhibitor for 3 years developed multiple metachronous foveolar-type gastric adenomas. Could the PPI be responsible?

TTP induced by acute HEV infection

A rare case of thrombotic thrombocytopenic purpura during HEV viremia in an elderly patient. Lymphoplasmapheresis plus rituximab contributed to platelet recovery.

Upadacitinib as salvage therapy for acute severe ulcerative colitis

Five men with ASUC that failed to respond to first-line corticosteroids received upadacitinib daily for 56 days. Short-term outcomes were favorable in terms of clinical response and clinical and corticosteroid-free remission.

Emphysematous cholecystitis

Emphysematous cholecystitis is a rare complication of acute cholecystitis that requires emergency cholecystectomy. In this case the patient had diabetes, which is a known predisposing factor.

Fecaloma causing small bowel obstruction

A woman with a year-long history of progressive constipation was diagnosed with small bowel obstruction due to adhesions. Further investigation revealed a fecal mass proximal to the ileocecal junction.

Enhanced activity of AIG after eradication of H. pylori

Early-stage autoimmune gastritis was diagnosed in a man with highly active Helicobacter pylori gastritis. Eradication therapy was followed by rapid exacerbation of atrophic changes.

Multimodality imaging features of systemic amyloidosis

Myocardial amyloidosis is often missed in the early stages. Understand the importance of multimodal imaging in diagnosing systemic AL amyloidosis, particularly when patients present with extra-cardiac symptoms.

Virtual sedation for colonoscopy

Virtual sedation was successfully used as an alternative to traditional pharmaceutical sedation in a woman with diverticular disease who was undergoing colonoscopy for the treatment of third-degree bleeding hemorrhoids.

A case of Crohn’s disease, IBS, and chronic fatigue

A 64-year-old man with a history of widely inactive Crohn's disease presented with IBS, chronic fatigue, and unexplained hip pain. What approach would you take to managing the patient?

An unusual finding in dysphagia

A man with a recent history of dysphagia for solid food was diagnosed with eosinophilic esophagitis presenting with a polyp at the gastroesophageal junction. After 12 weeks of oral budesonide the polyp was absent.

Polyarteritis nodosa presenting with severe GI bleeding

Although gastrointestinal involvement is known in polyarteritis nodosa, severe gastrointestinal bleeding due to gastric ulceration is relatively uncommon. This case sheds light on this rare complication.

Metronidazole-insufficient amoebic colitis

Persistent asymptomatic ulcerative lesions were detected in the cecum of a man previously treated with metronidazole for amoebic colitis. Combination therapy was needed to clear residual cysts.

Double-balloon method to remove button battery

After traditional removal methods failed, expanding the esophagus with a columnar balloon, clamping the button battery with foreign body forceps, and dragging with a disposable stone removal balloon was successful in a 17-month-old.

Minimally invasive treatment of a pancreaticopleural fistula

Successful treatment of a pancreaticopleural fistula with massive pleural effusion using a minimally invasive surgical approach. The case highlights that such a strategy should be considered if endoscopic treatment is not feasible.

What caused this child's recurrent abdominal pain?

Intestinal duplication cyst is a rare congenital malformation that is often misdiagnosed because of nonspecific clinical symptoms. Colonoscopy confirmed a cyst involving the colon, appendix, and ileum in this 4-year-old.

Exceptionally rare manifestation of papillary thyroid cancer

Spontaneous hepatic hemorrhage is a rare condition that is mostly seen in patients with hepatocellular carcinoma or hepatic adenomas. But in this case it was caused by metastasized papillary thyroid cancer.

Unusual cause of growth arrest, primary amenorrhea, and metabolic syndrome

IGF-1 deficiency was detected in a 16-year-old girl with primary amenorrhea, height and weight at the 3rd percentile, and a waist circumference at the 90th percentile, but what was the underlying cause?

A dietary cause of bronchiectasis

Would you consider gluten as the cause of a persistent cough and sputum production? This case explores the link between celiac disease and bronchiectasis with chronic rhinosinusitis.

ICI-induced encephalitis in a patient with HCC

Only the third reported case of encephalitis in a patient receiving atezolizumab plus bevacizumab for advanced hepatocellular carcinoma. The neurological symptoms quickly improved once steroid pulse therapy was started.