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Open Access 08-06-2024 | Gastric Cancer | Original Article

TMEM205 induces TAM/M2 polarization to promote cisplatin resistance in gastric cancer

Authors: Qiang Fu, Xuwei Wu, Zhongqi Lu, Ying Chang, Quanxin Jin, Tiefeng Jin, Meihua Zhang

Published in: Gastric Cancer

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Abstract

Cisplatin (DDP) is a basic chemotherapy drug for gastric cancer (GC). With the increase of DDP drug concentration in clinical treatment, cancer cells gradually became resistant. Therefore, it is necessary to find effective therapeutic targets to enhance the sensitivity of GC to DDP. Studies have shown that Transmembrane protein 205 (TMEM205) is overexpressed in DDP-resistant human epidermoid carcinoma cells and correlates with drug resistance, and database analyses show that TMEM 205 is also overexpressed in GC, but its role in cisplatin-resistant gastric cancer remains unclear. In this study, we chose a variety of experiments in vivo and vitro, aiming to investigate the role of TMEM 205 in cisplatin resistance in gastric cancer. The results showed that TMEM 205 promoted proliferation, stemness, epithelial–mesenchymal transition (EMT), migration and angiogenesis of gastric cancer cells through activation of the Wnt/β-catenin signaling pathway. In addition, TMEM205 promotes GC progression by inducing M2 polarization of tumor-associated macrophages (TAMs). These results suggest that TMEM205 may be an effective target to regulate the sensitivity of GC to DDP, providing a new therapeutic direction for clinical treatment.
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Literature
1.
go back to reference Pawluczuk E, Łukaszewicz-Zając M, Mroczko B. The role of chemokines in the development of gastric cancer-diagnostic and therapeutic implications. Int J Mol Sci. 2020;21(22)CrossRef Pawluczuk E, Łukaszewicz-Zając M, Mroczko B. The role of chemokines in the development of gastric cancer-diagnostic and therapeutic implications. Int J Mol Sci. 2020;21(22)CrossRef
2.
go back to reference Smyth EC, Nilsson M, Grabsch HI, van Grieken NCT, Lordick F. Gastric cancer. Lancet. 2020;396(10251):635–48.PubMedCrossRef Smyth EC, Nilsson M, Grabsch HI, van Grieken NCT, Lordick F. Gastric cancer. Lancet. 2020;396(10251):635–48.PubMedCrossRef
4.
go back to reference Saini U, Smith BQ, Dorayappan KDP, Yoo JY, Maxwell GL, Kaur B, et al. Targeting TMEM205 mediated drug resistance in ovarian clear cell carcinoma using oncolytic virus. J Ovarian Res. 2022;15(1):130.PubMedPubMedCentralCrossRef Saini U, Smith BQ, Dorayappan KDP, Yoo JY, Maxwell GL, Kaur B, et al. Targeting TMEM205 mediated drug resistance in ovarian clear cell carcinoma using oncolytic virus. J Ovarian Res. 2022;15(1):130.PubMedPubMedCentralCrossRef
5.
go back to reference Shen D-W, Ma J, Okabe M, Zhang G, Xia D, Gottesman MM. Elevated expression of TMEM205, a hypothetical membrane protein, is associated with cisplatin resistance. J Cell Physiol. 2010;225(3):822–8.PubMedPubMedCentralCrossRef Shen D-W, Ma J, Okabe M, Zhang G, Xia D, Gottesman MM. Elevated expression of TMEM205, a hypothetical membrane protein, is associated with cisplatin resistance. J Cell Physiol. 2010;225(3):822–8.PubMedPubMedCentralCrossRef
6.
go back to reference Shen DW, Gottesman MM. RAB8 enhances TMEM205-mediated cisplatin resistance. Pharm Res. 2012;29(3):643–50.PubMedCrossRef Shen DW, Gottesman MM. RAB8 enhances TMEM205-mediated cisplatin resistance. Pharm Res. 2012;29(3):643–50.PubMedCrossRef
7.
go back to reference Xu H, Dun S, Gao Y, Ming J, Hui L, Qiu X. TMEM107 inhibits EMT and invasion of NSCLC through regulating the Hedgehog pathway. Thorac Cancer. 2021;12(1):79–89.PubMedCrossRef Xu H, Dun S, Gao Y, Ming J, Hui L, Qiu X. TMEM107 inhibits EMT and invasion of NSCLC through regulating the Hedgehog pathway. Thorac Cancer. 2021;12(1):79–89.PubMedCrossRef
8.
go back to reference Liu Y, Zheng Q, He G, Zhang M, Yan X, Yang Z, et al. Transmembrane protein 215 promotes angiogenesis by maintaining endothelial cell survival. J Cell Physiol. 2019;234(6):9525–34.PubMedCrossRef Liu Y, Zheng Q, He G, Zhang M, Yan X, Yang Z, et al. Transmembrane protein 215 promotes angiogenesis by maintaining endothelial cell survival. J Cell Physiol. 2019;234(6):9525–34.PubMedCrossRef
9.
go back to reference Yang B, Wang F, Zheng G. Transmembrane protein TMEM119 facilitates the stemness of breast cancer cells by activating Wnt/beta-catenin pathway. Bioengineered. 2021;12(1):4856–67.PubMedPubMedCentralCrossRef Yang B, Wang F, Zheng G. Transmembrane protein TMEM119 facilitates the stemness of breast cancer cells by activating Wnt/beta-catenin pathway. Bioengineered. 2021;12(1):4856–67.PubMedPubMedCentralCrossRef
11.
go back to reference Zheng P, Chen L, Yuan X, Luo Q, Liu Y, Xie G, et al. Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells. J Exp Clin Cancer Res. 2017;36(1):53.PubMedPubMedCentralCrossRef Zheng P, Chen L, Yuan X, Luo Q, Liu Y, Xie G, et al. Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells. J Exp Clin Cancer Res. 2017;36(1):53.PubMedPubMedCentralCrossRef
12.
go back to reference He Z, Chen D, Wu J, Sui C, Deng X, Zhang P, et al. Yes associated protein 1 promotes resistance to 5-fluorouracil in gastric cancer by regulating GLUT3-dependent glycometabolism reprogramming of tumor-associated macrophages. Arch Biochem Biophys. 2021;702.PubMedCrossRef He Z, Chen D, Wu J, Sui C, Deng X, Zhang P, et al. Yes associated protein 1 promotes resistance to 5-fluorouracil in gastric cancer by regulating GLUT3-dependent glycometabolism reprogramming of tumor-associated macrophages. Arch Biochem Biophys. 2021;702.PubMedCrossRef
13.
go back to reference Li P, Hu J, Shi B, Tie J. Baicalein enhanced cisplatin sensitivity of gastric cancer cells by inducing cell apoptosis and autophagy via Akt/mTOR and Nrf2/Keap 1 pathway. Biochem Biophys Res Commun. 2020;531(3):320–7.PubMedCrossRef Li P, Hu J, Shi B, Tie J. Baicalein enhanced cisplatin sensitivity of gastric cancer cells by inducing cell apoptosis and autophagy via Akt/mTOR and Nrf2/Keap 1 pathway. Biochem Biophys Res Commun. 2020;531(3):320–7.PubMedCrossRef
15.
go back to reference Ge L, Li DS, Chen F, Feng JD, Li B, Wang TJ. TAZ overexpression is associated with epithelial-mesenchymal transition in cisplatin-resistant gastric cancer cells. Int J Oncol. 2017;51(1):307–15.PubMedCrossRef Ge L, Li DS, Chen F, Feng JD, Li B, Wang TJ. TAZ overexpression is associated with epithelial-mesenchymal transition in cisplatin-resistant gastric cancer cells. Int J Oncol. 2017;51(1):307–15.PubMedCrossRef
16.
go back to reference Cheng N, Bai X, Shu Y, Ahmad O, Shen P. Targeting tumor-associated macrophages as an antitumor strategy. Biochem Pharmacol. 2021;183: 114354.PubMedCrossRef Cheng N, Bai X, Shu Y, Ahmad O, Shen P. Targeting tumor-associated macrophages as an antitumor strategy. Biochem Pharmacol. 2021;183: 114354.PubMedCrossRef
17.
go back to reference Folkman JJ. Role of angiogenesis in tumor growth and metastasis. Semin Oncol. 2002;29(6 Suppl 16):15–8.PubMedCrossRef Folkman JJ. Role of angiogenesis in tumor growth and metastasis. Semin Oncol. 2002;29(6 Suppl 16):15–8.PubMedCrossRef
18.
go back to reference Yang F, Shao C, Wei K, Jing X, Qin Z, Shi Y, et al. miR-942 promotes tumor migration, invasion, and angiogenesis by regulating EMT via BARX2 in non-small-cell lung cancer. J Cell Physiol 2019; 234(12):23596–23607. Yang F, Shao C, Wei K, Jing X, Qin Z, Shi Y, et al. miR-942 promotes tumor migration, invasion, and angiogenesis by regulating EMT via BARX2 in non-small-cell lung cancer. J Cell Physiol 2019; 234(12):23596–23607.
19.
go back to reference Murray PJ, Allen JE, Biswas SK, Fisher EA, Gilroy DW, Goerdt S, et al. Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity. 2014;41(1):14–20.PubMedPubMedCentralCrossRef Murray PJ, Allen JE, Biswas SK, Fisher EA, Gilroy DW, Goerdt S, et al. Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity. 2014;41(1):14–20.PubMedPubMedCentralCrossRef
20.
go back to reference Morris DL, Singer K, Lumeng CN. Adipose tissue macrophages: phenotypic plasticity and diversity in lean and obese states. Curr Opin Clin Nutr Metab Care. 2011;14(4):341–6.PubMedPubMedCentralCrossRef Morris DL, Singer K, Lumeng CN. Adipose tissue macrophages: phenotypic plasticity and diversity in lean and obese states. Curr Opin Clin Nutr Metab Care. 2011;14(4):341–6.PubMedPubMedCentralCrossRef
21.
go back to reference Kiseleva V, Vishnyakova P, Elchaninov A, Fatkhudinov T, Sukhikh G. Biochemical and molecular inducers and modulators of M2 macrophage polarization in clinical perspective. Int Immunopharmacol. 2023;122:110583.PubMedCrossRef Kiseleva V, Vishnyakova P, Elchaninov A, Fatkhudinov T, Sukhikh G. Biochemical and molecular inducers and modulators of M2 macrophage polarization in clinical perspective. Int Immunopharmacol. 2023;122:110583.PubMedCrossRef
22.
go back to reference Fuentes L, Roszer T, Ricote M. Inflammatory mediators and insulin resistance in obesity: role of nuclear receptor signaling in macrophages. Mediators Inflamm. 2010;2010:219583.PubMedPubMedCentralCrossRef Fuentes L, Roszer T, Ricote M. Inflammatory mediators and insulin resistance in obesity: role of nuclear receptor signaling in macrophages. Mediators Inflamm. 2010;2010:219583.PubMedPubMedCentralCrossRef
23.
go back to reference Bohlson SS, O’Conner SD, Hulsebus HJ, Ho M-M, Fraser DA. Complement, c1q, and c1q-related molecules regulate macrophage polarization. Front Immunol. 2014;5:402.PubMedPubMedCentralCrossRef Bohlson SS, O’Conner SD, Hulsebus HJ, Ho M-M, Fraser DA. Complement, c1q, and c1q-related molecules regulate macrophage polarization. Front Immunol. 2014;5:402.PubMedPubMedCentralCrossRef
24.
go back to reference Scott TE, Lewis CV, Zhu M, Wang C, Samuel CS, Drummond GR, et al. IL-4 and IL-13 induce equivalent expression of traditional M2 markers and modulation of reactive oxygen species in human macrophages. Sci Rep. 2023;13(1):19589.PubMedPubMedCentralCrossRef Scott TE, Lewis CV, Zhu M, Wang C, Samuel CS, Drummond GR, et al. IL-4 and IL-13 induce equivalent expression of traditional M2 markers and modulation of reactive oxygen species in human macrophages. Sci Rep. 2023;13(1):19589.PubMedPubMedCentralCrossRef
26.
go back to reference Cutolo M, Campitiello R, Gotelli E, Soldano S. The Role of M1/M2 Macrophage Polarization in Rheumatoid Arthritis Synovitis. Front Immunol. 2022;13:867260.PubMedPubMedCentralCrossRef Cutolo M, Campitiello R, Gotelli E, Soldano S. The Role of M1/M2 Macrophage Polarization in Rheumatoid Arthritis Synovitis. Front Immunol. 2022;13:867260.PubMedPubMedCentralCrossRef
28.
29.
go back to reference Guo X-F, Liu J-P, Ma S-Q, Zhang P, Sun W-D. Avicularin reversed multidrug-resistance in human gastric cancer through enhancing Bax and BOK expressions. Biomed Pharmacother. 2018;103:67–74.PubMedCrossRef Guo X-F, Liu J-P, Ma S-Q, Zhang P, Sun W-D. Avicularin reversed multidrug-resistance in human gastric cancer through enhancing Bax and BOK expressions. Biomed Pharmacother. 2018;103:67–74.PubMedCrossRef
30.
go back to reference Ren X, Liu H, Zhang M, Wang M, Ma S. Co-expression of ING4 and P53 enhances hypopharyngeal cancer chemosensitivity to cisplatin in vivo. Mol Med Rep. 2016;14(3):2431–8.PubMedPubMedCentralCrossRef Ren X, Liu H, Zhang M, Wang M, Ma S. Co-expression of ING4 and P53 enhances hypopharyngeal cancer chemosensitivity to cisplatin in vivo. Mol Med Rep. 2016;14(3):2431–8.PubMedPubMedCentralCrossRef
31.
go back to reference Peng L, Sang H, Wei S, Li Y, Jin D, Zhu X, et al. circCUL2 regulates gastric cancer malignant transformation and cisplatin resistance by modulating autophagy activation via miR-142-3p/ROCK2. Mol Cancer. 2020;19(1):156.PubMedPubMedCentralCrossRef Peng L, Sang H, Wei S, Li Y, Jin D, Zhu X, et al. circCUL2 regulates gastric cancer malignant transformation and cisplatin resistance by modulating autophagy activation via miR-142-3p/ROCK2. Mol Cancer. 2020;19(1):156.PubMedPubMedCentralCrossRef
32.
go back to reference Tang Q-F, Ji Q, Qiu Y-Y, Cao A-L, Chi Y-F, Liang B, et al. Synergistic Effect of Zuo Jin Wan on DDP-Induced Apoptosis in Human Gastric Cancer SGC-7901/DDP Cells. Evid Based Complement Alternat Med. 2014;2014:724764.PubMedPubMedCentralCrossRef Tang Q-F, Ji Q, Qiu Y-Y, Cao A-L, Chi Y-F, Liang B, et al. Synergistic Effect of Zuo Jin Wan on DDP-Induced Apoptosis in Human Gastric Cancer SGC-7901/DDP Cells. Evid Based Complement Alternat Med. 2014;2014:724764.PubMedPubMedCentralCrossRef
33.
go back to reference Marx S, Dal Maso T, Chen JW, Bury M, Wouters J, Michiels C, et al. Transmembrane (TMEM) protein family members: Poorly characterized even if essential for the metastatic process. Semin Cancer Biol. 2020;60:96–106.PubMedCrossRef Marx S, Dal Maso T, Chen JW, Bury M, Wouters J, Michiels C, et al. Transmembrane (TMEM) protein family members: Poorly characterized even if essential for the metastatic process. Semin Cancer Biol. 2020;60:96–106.PubMedCrossRef
35.
go back to reference de Leon M, Cardenas H, Vieth E, Emerson R, Segar M, Liu Y, et al. Transmembrane protein 88 (TMEM88) promoter hypomethylation is associated with platinum resistance in ovarian cancer. Gynecol Oncol. 2016;142(3):539–47.PubMedPubMedCentralCrossRef de Leon M, Cardenas H, Vieth E, Emerson R, Segar M, Liu Y, et al. Transmembrane protein 88 (TMEM88) promoter hypomethylation is associated with platinum resistance in ovarian cancer. Gynecol Oncol. 2016;142(3):539–47.PubMedPubMedCentralCrossRef
37.
go back to reference Huang YK, Busuttil RA, Boussioutas A. The Role of Innate Immune Cells in Tumor Invasion and Metastasis. Cancers (Basel). 2021;13:23.CrossRef Huang YK, Busuttil RA, Boussioutas A. The Role of Innate Immune Cells in Tumor Invasion and Metastasis. Cancers (Basel). 2021;13:23.CrossRef
39.
go back to reference Chen X, Lv Y, Xu K, Wang X, Xiang RJC. DCBLD2 Mediates epithelial-mesenchymal transition-induced metastasis by cisplatin in lung adenocarcinoma. Cancers. 2021;13(6):1403.PubMedPubMedCentralCrossRef Chen X, Lv Y, Xu K, Wang X, Xiang RJC. DCBLD2 Mediates epithelial-mesenchymal transition-induced metastasis by cisplatin in lung adenocarcinoma. Cancers. 2021;13(6):1403.PubMedPubMedCentralCrossRef
40.
go back to reference Cocola C, Magnaghi V, Abeni E, Pelucchi P, Martino V, Vilardo L, et al. Transmembrane Protein TMEM230, a Target of Glioblastoma Therapy. Front Cell Neurosci. 2021;15:703431.PubMedPubMedCentralCrossRef Cocola C, Magnaghi V, Abeni E, Pelucchi P, Martino V, Vilardo L, et al. Transmembrane Protein TMEM230, a Target of Glioblastoma Therapy. Front Cell Neurosci. 2021;15:703431.PubMedPubMedCentralCrossRef
41.
go back to reference Shen K, Yu W, Yu Y, Liu X, Cui X. Knockdown of TMEM45B inhibits cell proliferation and invasion in gastric cancer. Biomed Pharmacother. 2018;104:576–81.PubMedCrossRef Shen K, Yu W, Yu Y, Liu X, Cui X. Knockdown of TMEM45B inhibits cell proliferation and invasion in gastric cancer. Biomed Pharmacother. 2018;104:576–81.PubMedCrossRef
42.
go back to reference Itoh H, Kadomatsu T, Tanoue H, Yugami M, Miyata K, Endo M, et al. TET2-dependent IL-6 induction mediated by the tumor microenvironment promotes tumor metastasis in osteosarcoma. Oncogene. 2018;37(22):2903–20.PubMedCrossRef Itoh H, Kadomatsu T, Tanoue H, Yugami M, Miyata K, Endo M, et al. TET2-dependent IL-6 induction mediated by the tumor microenvironment promotes tumor metastasis in osteosarcoma. Oncogene. 2018;37(22):2903–20.PubMedCrossRef
43.
go back to reference Li Y, Guo W, Liu S, Zhang B, Yu BB, Yang B, et al. Silencing Transmembrane Protein 45B (TNEM45B) Inhibits Proliferation, Invasion, and Tumorigenesis in Osteosarcoma Cells. Oncol Res. 2017;25(6):1021–6.PubMedPubMedCentralCrossRef Li Y, Guo W, Liu S, Zhang B, Yu BB, Yang B, et al. Silencing Transmembrane Protein 45B (TNEM45B) Inhibits Proliferation, Invasion, and Tumorigenesis in Osteosarcoma Cells. Oncol Res. 2017;25(6):1021–6.PubMedPubMedCentralCrossRef
44.
go back to reference Qiao W, Han Y, Jin W, Tian M, Chen P, Min J, et al. Overexpression and biological function of TMEM48 in non-small cell lung carcinoma. Tumour Biol. 2016;37(2):2575–86.PubMedCrossRef Qiao W, Han Y, Jin W, Tian M, Chen P, Min J, et al. Overexpression and biological function of TMEM48 in non-small cell lung carcinoma. Tumour Biol. 2016;37(2):2575–86.PubMedCrossRef
45.
go back to reference Li H, Zhang M, Linghu E, Zhou F, Herman JG, Hu L, et al. Epigenetic silencing of TMEM176A activates ERK signaling in human hepatocellular carcinoma. Clin Epigenetics. 2018;10(1):137.PubMedPubMedCentralCrossRef Li H, Zhang M, Linghu E, Zhou F, Herman JG, Hu L, et al. Epigenetic silencing of TMEM176A activates ERK signaling in human hepatocellular carcinoma. Clin Epigenetics. 2018;10(1):137.PubMedPubMedCentralCrossRef
46.
go back to reference Wang Y, Ji L, Ji C, Wang F. Multi-omics approaches establishing histone modification based prognostic model in glioma patients and further verification of the carcinogenesis mechanism. Funct Integr Genomics. 2023;23(4):307.PubMedCrossRef Wang Y, Ji L, Ji C, Wang F. Multi-omics approaches establishing histone modification based prognostic model in glioma patients and further verification of the carcinogenesis mechanism. Funct Integr Genomics. 2023;23(4):307.PubMedCrossRef
47.
go back to reference Pastushenko I, Blanpain C. EMT Transition States during Tumor Progression and Metastasis. Trends Cell Biol. 2019;29(3):212–26.PubMedCrossRef Pastushenko I, Blanpain C. EMT Transition States during Tumor Progression and Metastasis. Trends Cell Biol. 2019;29(3):212–26.PubMedCrossRef
48.
go back to reference Ashrafizadeh M, Zarrabi A, Hushmandi K, Kalantari M, Mohammadinejad R, Javaheri T, et al. Association of the Epithelial-Mesenchymal Transition (EMT) with Cisplatin Resistance. Int J Mol Sci. 2020;21:11.CrossRef Ashrafizadeh M, Zarrabi A, Hushmandi K, Kalantari M, Mohammadinejad R, Javaheri T, et al. Association of the Epithelial-Mesenchymal Transition (EMT) with Cisplatin Resistance. Int J Mol Sci. 2020;21:11.CrossRef
49.
go back to reference Zhang X, He Y, Jiang Y, Bao Y, Chen Q, Xie D, et al. 2021 TMEM229A suppresses nonsmall cell lung cancer progression via inactivating the ERK pathway. Oncol Rep.; 46(2). Zhang X, He Y, Jiang Y, Bao Y, Chen Q, Xie D, et al. 2021 TMEM229A suppresses nonsmall cell lung cancer progression via inactivating the ERK pathway. Oncol Rep.; 46(2).
50.
go back to reference Solan JL, Lampe PD. Connexin43 phosphorylation: structural changes and biological effects. Biochem J. 2009;419(2):261–72.PubMedCrossRef Solan JL, Lampe PD. Connexin43 phosphorylation: structural changes and biological effects. Biochem J. 2009;419(2):261–72.PubMedCrossRef
53.
go back to reference Qin T, Li B, Feng X, Fan S, Liu L, Liu D, et al. Abnormally elevated USP37 expression in breast cancer stem cells regulates stemness, epithelial-mesenchymal transition and cisplatin sensitivity. J Exp Clin Cancer Res. 2018;37(1):287.PubMedPubMedCentralCrossRef Qin T, Li B, Feng X, Fan S, Liu L, Liu D, et al. Abnormally elevated USP37 expression in breast cancer stem cells regulates stemness, epithelial-mesenchymal transition and cisplatin sensitivity. J Exp Clin Cancer Res. 2018;37(1):287.PubMedPubMedCentralCrossRef
54.
go back to reference Le F, Yang L, Han Y, Zhong Y, Zhan F, Feng Y, et al. TPL Inhibits the invasion and migration of drug-resistant ovarian cancer by targeting the PI3K/AKT/NF-kappaB-signaling pathway to inhibit the polarization of M2 TAMs. Front Oncol. 2021;11: 704001.PubMedPubMedCentralCrossRef Le F, Yang L, Han Y, Zhong Y, Zhan F, Feng Y, et al. TPL Inhibits the invasion and migration of drug-resistant ovarian cancer by targeting the PI3K/AKT/NF-kappaB-signaling pathway to inhibit the polarization of M2 TAMs. Front Oncol. 2021;11: 704001.PubMedPubMedCentralCrossRef
55.
57.
go back to reference Yu X, Zhang X, Zhang Y, Jiang G, Mao X, Jin F. Cytosolic TMEM88 promotes triple-negative breast cancer by interacting with Dvl. Oncotarget. 2015;6(28):25034–45.PubMedPubMedCentralCrossRef Yu X, Zhang X, Zhang Y, Jiang G, Mao X, Jin F. Cytosolic TMEM88 promotes triple-negative breast cancer by interacting with Dvl. Oncotarget. 2015;6(28):25034–45.PubMedPubMedCentralCrossRef
58.
go back to reference Herrera-Quiterio GA, Encarnación-Guevara S. The transmembrane proteins (TMEM) and their role in cell proliferation, migration, invasion, and epithelial-mesenchymal transition in cancer. Front Oncol. 2023;13:1244740.PubMedPubMedCentralCrossRef Herrera-Quiterio GA, Encarnación-Guevara S. The transmembrane proteins (TMEM) and their role in cell proliferation, migration, invasion, and epithelial-mesenchymal transition in cancer. Front Oncol. 2023;13:1244740.PubMedPubMedCentralCrossRef
60.
go back to reference Flamant L, Roegiers E, Pierre M, Hayez A, Sterpin C, De Backer O, et al. TMEM45A is essential for hypoxia-induced chemoresistance in breast and liver cancer cells. BMC Cancer. 2012;12:391.PubMedPubMedCentralCrossRef Flamant L, Roegiers E, Pierre M, Hayez A, Sterpin C, De Backer O, et al. TMEM45A is essential for hypoxia-induced chemoresistance in breast and liver cancer cells. BMC Cancer. 2012;12:391.PubMedPubMedCentralCrossRef
Metadata
Title
TMEM205 induces TAM/M2 polarization to promote cisplatin resistance in gastric cancer
Authors
Qiang Fu
Xuwei Wu
Zhongqi Lu
Ying Chang
Quanxin Jin
Tiefeng Jin
Meihua Zhang
Publication date
08-06-2024
Publisher
Springer Nature Singapore
Published in
Gastric Cancer
Print ISSN: 1436-3291
Electronic ISSN: 1436-3305
DOI
https://doi.org/10.1007/s10120-024-01517-2
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